Our keywords: Virology, neurobiology, cell biology, synaptic plasticity, intracellular trafficking, neurodegeneration, live cell imaging, machine learning, antivirals, secretion, extracellular vesicles, … Viruses we particularly like these days: Coronaviruses, Flaviviruses, Bunyaviruses, Hepatitis B virus, HIV, …
The team members are working together on interdisciplinary fields in order to tackle major questions associated to virology, cell biology and neurobiology.
Plasmids from the team are available at:
Our team « Membrane Dynamics & Viruses » (MDV) aims at studying virus-host interactions at different spatiotemporal scales. The viruses studied in the lab allow us to better understand physiological molecular and cellular mechanisms, and vice-versa, the investigation of cellular processes provides valuable information regarding viral subversion mechanisms.
Specifically, our projects are focusing on three complementary axes:
- The intracellular transport in/out: how do viruses (HBV, HCV, SARS-CoV-2, …) interact with their receptor at the cell surface of target cell? Conversely, how does the cell control neo-synthesized transmembrane viral receptor secretion and extracellular vesicles?
- How viruses (Zika and HIV) cross the blood-brain barrier? What is the impact of brain exposure to viruses (Flaviviruses, Coronaviruses, Bunyaviruses, HIV, …)?
- Development of novel antiviral molecules with broad spectrum. How to improve their potency, stability, solubility, bioavailability? What is the host protein targeted?
In project I, we have identified that DNAseI is encapsidated into viral particles during HBV assembly (Hallez et al., Nature Microbiol, 2019) and imaged the association of Core-DNAseI in real time (Figure 1).
Figure 1. 5D reconstruction of the spatiotemporal dynamics of HBV-Core (green) and DNAseI (red).
As part of project II, we found that Zika virus and HIV enhance monocyte transmigration through the blood-brain barrier in vitro and in vivo. Our results reinforce the “Trojan Horse” hypothesis (Figure 2).
Figure 2. Viral particles in the bloodstream infect (or are captured by) blood cells, which will transmigrate through the endothelium, allowing the virus to cross this impermeable barrier.
We are routinely employing techniques related to the study of HBV, HCV, HIV, and Zika viruses, including RT-qPCR, Western blot, flow cytometry, immunostaining, RNA interference, plaque assays, …
We also developed advanced methods for the study of virus-host interactions such as CRISPR/Cas9 knock-in/out, RUSH, high resolution 3D confocal live cell imaging, mass spectrometry, xenotypic zebrafish embryo model system, human explants, cerebral orgaoids derived from stem cells, …
We have implemented the culture of stem cell derived cerebral organoids in the lab (Figure 3).
Figure 3. Confocal imaging of cerebral organoids
The philosophy of the lab is to go beyond technological limitations, not accepting “we can’t do it” as an answer, but rather “how are we going to achieve it?”.
The team is affiliated to the French society for cell biology (SBCF) and R.Gaudin is an elected member of the SBCF board council since 2016
R.Gaudin has been nominated as “full member” of the World Society for Virology (WSV) in 2019.
Funding
Ongoing:
- ANRS, ANR, CNRS-INSB, SATT AxlR.
Past (since 2016) :
- Atip-Avenir, FRM, EMBO LTF, INSERM-région, chaire d’attractivité Idex (University of Strasbourg), Prestige (european), initiation of collaboration with China (franco-chinese ambassy).
Current team members
- Raphaël GAUDIN, team leader, research director CNRS (DR2)
- Solange Desagher, research director CNRS (DR2)
- Maïka Deffieu, researcher CNRS (CRCN)
- Solène Lebrun, assistant engineer CNRS staff (AI)
- Lorena Kumarasinghe, post-doc (CNRS)
- Gaia Cogrossi, 3rd year PhD Student (FRM-UM)
- Jules Bouget, 2nd year PhD Student (CBS2-Univ Montpellier)
- Barbara Gorda, research associate (CNRS)
- Willy Lutz, shared 1st year PhD Student (CBS2-Univ Montpellier)
- Emilie Bechard-Drimaracci, post-doc (CNRS)
- Glaucia Maria Almeida, post-doc (CNRS)
- Inès Ouedraogo, research engineer (CNRS)
- Maria Nicol “Niky” Arroyo, post-doc (CNRS)
Past team members
- Maya Ouabdesselam, Master 2 student
- Fahima Mokhnache, research associate (CNRS)
- Yohan Beaumatin, Master 2 student
- Yukiko Iwasaki, shared post-doc (CNRS)
- Corentin Bernou, post-doc (CNRS)
- Diana Brychka, PhD student and transitionning post-doc (ANRS)
- Yonis Bare, post-doc (Univ Montpellier)
- Emma partiot, PhD student
- Brittany Zanantsoa, Master 2 student
- Mona Meyer, Master 2 student
- Ilham Jaafari, Master 1 student
- Malvina Schatz, research associate (Région Occitanie)
- Joëlle Hornebeck, shared Master 1 student
- Diane Bégarie, research associate
- Janine Wenker, research associate – Today: PhD Student, Tours (France)
- Clarisse Montet, Master 2 student
- Khiara Berkowitz-Sklar, student – Today: Princeton University undergrad (USA)
- Claire Dupont, research associate (IRIM) – Today: engineer imaging facility MRI
- William Bakhache, research associate (SATT) – Today: post-doc, NIH, USAHafida Boultam, Master 2 student
- Nilda Vanesa Ayala-Nunez, Post-doc – Today: project manager at EMPA (Switzerland)
- Camille Clément, PhD student
- Eliott Vernier, Student Master 1 BIOTIN Montpellier – Today: Master 2 BIOTIN
- Cristina Dorobantu, Post-doc (EMBO LTF) – Today: Project manager at Janssen Vaccines & Prevention B.V. (The Netherlands)
- Vincent Lucansky, Research engineer (FRM) – Today: Staff scientist at Biomedical Center Martin JFM CU (Slovakia)
- Ieva Cesonyte, ESBS engineer school student – Today: PhD student in Dr. van Kuppeveld lab, Utrecht (The Netherlands)
- Lucie Klughertz, Master 2 student in Virology – Today: research assistant at Polyplus Transfection Laurine Seltz, ESBS engineer school student
Papers since 2015
Bold : team members
* Co-first authors
# Corresponding authors
- Monitoring the dynamics of exosomes through the tracking of Rab7 partners. Bare Y, Delalande F, Hirschler A, Cazevieille C, Lucansky V, Carapito C, Gaudin R#, Deffieu MS#. BioRxiv. 2025. doi: https://doi.org/10.1101/2025.10.07.680694
- When viral infections rewire neural circuits: towards cognitive virology. Bouget J, Partiot E, Gaudin R#. Trends in Neurosciences. Dec 2025. doi: 10.1016/j.tins.2025.10.005.
- Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs. McKellar J, Cadènes J, García de Gracia F, Aubé C, Chaves Valadão AL, Tauziet M, Arnaud-Arnould M, Rebendenne A, Kociánová L, Labaronne E, Ricci EP, Delaval B, Gaudin R, Naffakh N, Gallois-Montbrun S, Moncorgé O, Goujon C. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2025 Oct. doi: 10.1073/pnas.2418935122.
- Assessing the Nature of Human Brain-Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air-liquid Microfluidic Platform. Bernou C, Iwasaki Y, Lutz W, Almeida G, Béchard E, Delalande F, Rompais M, Bouget J, Gorda B, Cazevieille C, Bare Y, Carapito C, Colomb S, Ganesh G, Gaudin R#. Advanced Science. 2025 Oct. doi: 10.1002/advs.202511194.
- Triggers of viral encephalitis: a brain teaser to be solved! Sonneville R#, Lannuzel A, Mathieu C, Gonzalez-Dunia D, Gaudin R#. Annals of Intensive Care. 2025 Mar. Editorial. doi: 10.1186/s13613-025-01451-1.
- Cell Bio Notes: A New Article Type for Cell Biochemistry and Function. Gaudin R, Heath RJ. Cell Biochemistry & Function. 2025 Feb. Editorial. doi: 10.1002/cbf.70062
- The endoplasmic reticulum as a cradle for virus and extracellular vesicle secretion. Bare Y#, Defourny K, Bretou M, Van Niel G, Nolte-‘t Hoen E, Gaudin R#. Trends in Cell Biology. 2024 Dec. Review. doi: 10.1016/j.tcb.2024.11.008.
- Investigating human monocyte adhesion, migration and transmigration and their modulation by Zika virus. Partiot E, Brychka D, Gaudin R#. European Journal of Cell Biololgy. 2024 Aug. doi: 10.1016/j.ejcb.2024.151453.
- Organotypic culture of post-mortem adult human brain explants exhibits synaptic plasticity. Iwasaki Y*, Bernou C*, Gorda B, Colomb S, Ganesh G#, Gaudin R#. Brain Stimulation. Aug 2024. doi: 10.1016/j.brs.2024.08.010.
- Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion. Brychka D, Ayala-Nunez NV, Bare Y, Dupas A, Partiot E, Mittelheisser V, Lucansky V, Goetz J, Osmani N, Gaudin R#. EMBO Reports, 2024 July. doi: 10.1038/s44319-024-00190-x.
- Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis. Partiot E, Hirschler A, Colomb C, Lutz W, Claeys T, Delalande F, Deffieu MS, Bare Y, Roels J, Gorda B, Bons J, Callon D, Andreoletti L, Labrousse M, Jacobs FMJ, Rigau V, Charlot B, Martens L, Carapito C, Ganesh G, Gaudin R#. Nature Microbiology. 2024 Apr. doi: 1038/s41564-024-01657-2.
- Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies. Partiot E*, Gorda B*, Lutz W, Lebrun S, Khalfi P, Mora S, Charlot B, Majzoub K, Desagher S, Ganesh G, Colomb C, Gaudin R#. EMBO Molecular Medicine. 2024 Mar. 1038/s44321-024-00039-9. Journal’s cover April 2024.
- Monocytic Occludin promotes monocyte transmigration and HIV neuroinvasion. Brychka D, Ayala-Nunez NV, Bare Y, Dupas A, Partiot E, Mittelheisser V, Lucansky V, Goetz J, Osmani N, Gaudin R#. BioRxiv, 2023 Sept. doi: 10.1101/2023.09.11.557242
- TMED10 mediates the loading of neosynthesised Sonic Hedgehog in COPII vesicles for efficient secretion and signalling. Bare Y, Matusek T, Vriz S, Deffieu MS, Thérond PP, Gaudin R#. Cellular and Molecular Life Science. 2023 Aug. doi: 10.1007/s00018-023-04918-1.
- LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes. Pradel B, Deffieu MS, Robert-Hebmann V, Cantaloube G, Faure M, Chazal N, Gaudin R, Espert L. 2023 Jul. doi: 10.1101/2023.07.11.548555
- Protruding cantilever microelectrode array to monitor the inner electrical activity of cerebral organoids. Phouphetlinthong O*, Partiot E*, Bernou C, Sebban A, Gaudin R#, Charlot B#. Lab on a Chip. 2023 July. doi: 10.1039/D3LC00294B. Selected HOT article 2023.
- Special issue for biology of the cell “intracellular trafficking of viruses”. Gaudin R# & Deffieu MS. Biology of the Cell. 2023 May. doi: 10.1111/boc.202300046
- Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration. Sponsel J, Guo Y, Hamzam L, Lavanant AC, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, Titz A, Flacher V, Römer W, Mueller CG. EMBO Reports. 2023 Mar. doi: 10.15252/embr.202255971
- Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function. Partiot E, Hirschler A, Colomb C, Lutz W, Claeys T, Delalande F, Deffieu MS, Roels REJ, Bons J, Callon D, Andreoletti L, Labrousse M, Jacobs FMJ, Rigau V, Charlot B, Martens L, Carapito C, Ganesh G, Gaudin R#. BioRxiv. 2022 Sept. doi: 1101/2022.09.13.507484.
- Clustering and mapping the first COVID-19 outbreak in France. Darques R, Trottier J, Gaudin R, Ait-Mouheb N. BMC Public Health. 2022 Jul. doi: 10.1186/s12889-022-13537-7.
- Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. Maarifi G, Martin MF, Zebboudj A, Boulay A, Nouaux P, Fernandez J, Lagisquet J, Garcin D, Gaudin R, Arhel NJ, Nisole S. Cell Chemical Biology. 2022 Jul. doi: 10.1016/j.chembiol.2022.05.009.
- Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization. Deffieu MS*, Clément C*, Dorobantu C, Partiot E, Bare Y, Faklaris O, Rivière B, Ayala-Nunez NV, Baumert TF, Rondé P, Mély Y, Lucansky V, Gaudin R#. Hepatology. 2022 Apr. doi: 10.1002/hep.32514.
- Targeting tight junctions to fight against viral neuroinvasion. Gaudin R#, Brychka D, Sips GJ, Ayala-Nunez V#. Trends in Molecular Medicine. 2021 Nov 19:S1471-4914(21)00279-3. doi: 10.1016/j.molmed.2021.10.007.
- Pharmacological perturbation of intracellular dynamics as a SARS-CoV-2 antiviral strategy. Bakhache W, Partiot E, Lucansky V, Bare Y, Bonaventure B, Goujon C, Bories C, Deffieu MS, Gaudin R#. 2021 Sept. BioRxiv. doi: 10.1101/2021.09.10.459410.
- [Will we read the future of COVID-19 in wastewater?]. Gaudin R#, Lepeuple AS. Virologie (Montrouge). 2021 Feb 1;25(1):5-7. doi: 10.1684/vir.2021.0875.
- Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway. Deffieu MS#, Cesonyte I, Delalande F, Boncompain G, Dorobantu C, Song E, Lucansky V, Hirschler A, Cianferani S, Perez F, Carapito C, Gaudin R#. Science Advances. 2021 Jan 8;7(2):eaba7803. doi: 10.1126/sciadv.aba7803.
- Tracking Mechanisms of Viral Dissemination In Vivo. Gaudin R#, Goetz JG#. Trends in Cell Biology. 2021 Jan;31(1):17-23. doi: 10.1016/j.tcb.2020.09.005
- Post-lockdown detection of SARS-CoV-2 RNA in the wastewater of Montpellier, France. Trottier J, Darques R, Ait Mouheb N, Partiot E, Bakhache W, Deffieu MS, Gaudin R#. One Health. 2020 Dec; 10:100157. doi: 10.1016/j.onehlt.2020.100157.
- Mapping Cell Membrane Organization and Dynamics Using Soft Nano-Imprint Lithography. Sansen T, Sanchez Fuentes D, Rathar R, Colom A, El Alaoui F, Viaud J, Macchione M, de Rossi S, Matile S, Gaudin R, Bäcker V, Carretero-Genevrier A, Picas L. ACS Appl Mater Interfaces. 2020 May 28. doi: 10.1021/acsami.0c05432.
- [Monocytes and Zika virus: the brain’s conquest]. Partiot E & Gaudin R#. Medecine/Sciences (Paris). 2020 May;36(5):449-451. doi: 10.1051/medsci/2020072. Epub 2020 May 26.
- A viral journey to the brain: Current considerations and future developments. Ayala-Nunez NV & Gaudin R#. PLoS Pathogens. 2020 May 21;16(5):e1008434. doi: 10.1371/journal.ppat.1008434.
- Characterisation of endogenous Claudin-1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock-in cells. Clément CMH*, Deffieu MS*, Dorobantu CM, Baumert TF, Ayala-Nunez NV, Mély Y, Ronde P, Gaudin R#. Biology of the Cell. 2020 Feb 7. doi: 10.1111/boc.201900085.
- Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T. Journal of Cell Biology. 2020 Mar 2;219(3). pii: e201908142. doi: 10.1083/jcb.201908142.
- Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. Ayala-Nunez NV, Follain G, Delalande F, Hirschler A, Partiot E, Hale GL, Bollweg BC, Roels J, Chazal M, Bakoa F, Carocci M, Bourdoulous S, Faklaris O, Zaki SR, Eckly A, Uring-Lambert B, Doussau F, Cianferani S, Carapito C, Jacobs FMJ, Jouvenet N, Goetz JG, Gaudin R#. Nature Communications. 2019 Sep 27;10(1):4430. doi: 10.1038/s41467-019-12408-x.
- Imaging the Hepatitis B Virus: Broadcasting Live. Deffieu MS & Gaudin R#. Trends in Microbiology. 2019 Aug 14. pii: S0966-842X(19)30191-X. doi: 10.1016/j.tim.2019.07.007.
- Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S. Cell Reports. 2019 Jun 4;27(10):3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017.
- Hypoxia induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus. Hallez C, Li X, Suspène R, Thiers V, Bouzidi1 MS, Dorobantu C, Lucansky V, Wain-Hobson S, Gaudin R#, Vartanian JP#. Nature Microbiology. 2019 Apr 1. doi: 10.1038/s41564-019-0405-x.
- Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Théry C, Witwer KW, …, Gaudin R, … (> 300 authors). Journal of Extracellular Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750
- The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G. Nature Communication. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2.
- The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Coulter ME*, Dorobantu CM*, Lodewijk GA*, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ#, Gaudin R#, Walsh CA#. Cell Reports. 2018 Jul 24;24(4):973-986.e8. doi: 10.1016/j.celrep.2018.06.100.
- Blood monocytes sample MelanA/MART1 antigen for long-lasting cross-presentation to CD8+ T cells after differentiation into dendritic cells. Faure F, Jouve M, Lebhar-Peguillet I, Sadaka C, Sepulveda F, Lantz O, Berre S, Gaudin R, Sánchez-Ramón S, Amigorena S. International Journal of Cancer. 2018 Jan 1;142(1):133-144. doi: 10.1002/ijc.31037.
- Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. He K, Marsland R, Upadhyayula S, Song E, Dang S, Capraro BR, Wang W, Skillern W, Gaudin R, Ma M and Kirchhausen T. Nature. 2017 Dec 13. doi: 10.1038/nature25146. Highlighted in F1000Prime.
- Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9. Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T. Scientific Reports. 2016 Nov 14;6:36921. doi: 10.1038/srep36921.
- Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Aguet F*, Upadhyayula S*, Gaudin R*, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Molecular Biology of the Cell. 2016 Nov 7;27(22):3418-3435. Highlighted.
- Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes. Verrier ER, Colpitts CC, Bach C, Heydmann L, Zona L, Xiao F, Thumann C, Crouchet E, Gaudin R, Sureau C, Cosset FL, McKeating JA, Pessaux P, Hoshida Y, Schuster C, Zeisel MB, Baumert TF. Cell Reports. 2016 Oct 25;17(5):1357-1368. doi: 10.1016/ j.celrep.2016.09.084.
- Identification and characterization of a novel broad spectrum virus entry inhibitor. Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang P, Whelan SP, Ross SR, Kirchhausen T#, Gaudin R#. Journal of Virology. Feb 2016. doi: 10.1128/JVI.00103-16.
- [Enhancing our single molecule experience using Crispr]. Gaudin R. Médecine/Sciences. Nov 2015 31(11):959-61. doi: 10.1051/medsci/20153111007. Highlighted.
- Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles. Gaudin R# and Barteneva NS#. Nature Communications. Feb 2015 2;6:6022. doi: 10.1038/ncomms7022.
- Christine Carapito, François Delalande & Aurélie Hirschler – LSMBO, Strasbourg
- Jacky Goetz, Nael Osmani – INSERM U1109, Strasbourg
- Pascal Thérond, Tamas Matusek – Institut de Biologie Valrose (IBV), Université de Nice, France
- Pablo Vargas – INEM, Paris
- Benoit Charlot – IES, Montpellier
- Ganesh Gowrishankar – LIRMM, Montpellier
- Sophie Colomb – Montpellier Hospital (CHU)
- Frank Jacobs – University of Amsterdam, The Netherlands
- Eli Song – Institute of Biophysics, Chinese Academy of Science, Beiging, China
- Vincent Lucansky – Biomedical Center, Martin, Slovakia
Celebration of two accepted papers with the team!
From lower left to: Emma, Corentin, Raph, Solène, Ganesh, Maika, Solange, Basia, Diana, Yonis, Willy, Jules, Gaia, and Yukiko.
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Feb 2024
The lab is expanding… We are happy to welcome three new team members: Jules Bouget (Master 2 internship), Brittany Zanantsoa (Master 2 internship) and Lorena Kumarasinghe (post-doc). Jules will work for 6 months on the impact of bunyaviruses on neural cells at the interface with Basia, Willy, Corentin and Solange. Brittany will work with Maika on various aspects of the trafficking of the Hepatitis B virus. Lorena will work with Solange on the regulation of aSynuclein transcription. Welcome to all!
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January 2024
It’s our pleasure to welcome Solange Desagher, a research director at CNRS, in the team. Solange has a strong expertise in neuronal cell death, TRIM proteins, and the transcriptional regulation of alpha synuclein, an pivotal player in Parkinson’s disease.
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Dec 2023
Great PhD defense by Emma Partiot. Thanks to jury members: Muriel Coulpier (ANSES, Maisons-Alfort), Cyrille Mathieu (CIRI, Lyon), Daniel Dunia (Infinity, Toulouse), Sara Salinas (PCCEI, Montpellier), and Nathalie Chazal (IRIM, Monptellier).
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October 2023
The usual Halloween party took place, but I don’t have photos (or don’t want to show it…)!
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January 2023
We are happy to welcome Solène Lebrun in the team. She will be an “assistant engineer” (permanent staff CNRS). Solène will help us with all sorts of advanced methods used in the lab, but also lead projects requiring strong technical developments.
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September 2022
We are welcoming Willy Lutz in the team. Willy will help us with data processing using artificial intelligence to predict the impact of viruses on biological samples. Welcome!
July 2022
Afterlab climbing for the upcoming departure of Diane from the lab next month.
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June 2022
Afterlab evening at the beach for Emma’s birthday !
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June 2022
Welcome to Gaia Cogrossi, ERASMUS student, who will work on antiviral development against coronaviruses.
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April 2022
Here is Yukiko Iwasaki ane Joelle Hornebeck. Yukiko is a post-doctoral fellow in the team of Ganesh Gowrishankar (LIRMM, Montpellier), who is hosted in our lab to work on programming, artificial intelligence and signal processing. Joelle is a Master 1 student in infectiology who develop new tools to visualize viruses and bacteria. To this end, she is at the interface between our lab and the lab of Matteo Bonazzi (IRIM). Welcome to both!
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Feb 2022
Welcome to our two new members: Dr. Barbara Gorda (Basia) and Dr. Malvina Schatz.
While Basia is exploring new lines of research in neuro-virology, Malvina took over the development of a series of patented antiviral compounds, to bring it to the next stage.
Welcome to both!
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Oct 2021
Halloween party!!! Everyone had great costumes.
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Sept 2021
The MDV team is happy to welcome Diane Bégarie who just finished her gad studies at ENS Lyon. Diane will be an engineer in the team, working at the interface between neurobiology and viruses in collaboration with the other team members.
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May 2021
Welcome to Khiara Berkowitz-Sklar, undergraduate student at Princeton University (USA), who will stay with us until the end of August. Khiara will work on the molecular and cell biology of the intracellular trafficking of cellular and viral proteins.
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Mar 2021
Welcome to Clarisse Montet, Master 2 student (DTech Bio) working in Benoit Charlot lab (IES Montpellier) to build microchannels, and our lab to grow 3D endothelial tubes.
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Feb 2021
New member in the lab: Claire Dupont, engineer, whom will work at the interface between our team and the one of Matteo Bonazzi (IRIM) to develop new imaging tools. Welcome !
Oct 2020
Two newcomers this month:
Diana Brychka (left), 1-year engineer, will pursue our work on HIV and transmigration.
Vincent Lucansky (right), 3-months visiting scientist from Slovakia, will develop projects based on new molecular biology tools.
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May 2020
Release of two scientific review from the lab the same week! Congrats to Emma and Vanesa for their drafting work.
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May 2020
William Bakhache, a ready-to-defend PhD student from Laurence Briant team (IRIM) is recruited as an engineer (SATT AxlR of Montpellier) to develop antiviral projects through a mini-consortium at IRIM coordinated by Raphael Gaudin and including te groups of Laurence Briant, Caroline Goujon and Jean-Marie Péloponèse.
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Mar 2020
The institute closes down as France is entering in lock-down. The team, Maika and Raph, followed by Yonis, stay at the bench to further develop broad spectrum antivirals showing potent activity against SARS-CoV-2.
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Feb 2020
Lab outing: Bowling -> I don’t have pictures, sorry!
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Jan 2020
Despite an imminent Brexit coming up, Yonis Bare, whom has just defended his thesis at King’s College London, joins our team as post-doctoral fellow. He will study extracellular vesicle secretion, and maybe even some HIV…!
Welcome
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Dec 2019 Happy ending: Camille Clément defended her thesis on Dec 16th 2019, despite the strike that firced us to have to reviewers by videoconference. Anyway, everything ends well and Camille is today proud to be called Dr. Clément. Congratulations!!!
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Oct 2019
It’s official: Emma Partiot is starting her PhD in the MDV team! Let’s go for 3 years of transmigration!
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Sept 2019
the “Spicy challenge”, organised by Vanesa: a lot of fun!
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Aug 2019
We can’t say who it is just yet, but it seems that a new member is going to join the team in Jan 2020; and it will happen despite the Brexit…
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Aug 2019
New review written by Maika and Raphael about live cell imaging of the hepatitis B virus just published in Trends Microbiol. Congrats!
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July 2019
The lab has (finally) its own twitter account: for more news about the team’s activities and scientific interests, follow us: @Gaudinlab
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May 2019
Lab day: Axe throwing in Castelnau-le-Lez. No one was hurt!
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Apr 2019
We are happy to welcome Emma Partiot in our team, starting April 1st, 2019. Emma will work in collaboration with all the team members and initiate her own PhD project in September.
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Dec 2018
Our recently published work has been highlighted in the last issue of the Inserm magazine :
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Nov 2018
Congratulations to Vanesa who won the 1st prize for best oral presentation at the SoMM 2018 meeting!
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Nov 2018
We are happy to welcome Eliott Vernier, student from the Master 1 BIOTIN of Montpellier. He will work with Vanesa and Raphael to develop innovative technologies (Crispr, microfluidics, …).
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Oct 2018
The MDV team started in Alsace in 2016. We moved to Montpellier on October 1st, 2018. After heavy unpacking and heavy rain episods, we are back to the lab, ready to move forward our research projects at IRIM, in an exciting and stimulating environment.
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Karting day, Feb 2018
We are always looking for motivated students that are interested in our work.
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On Nov 19th, 2018. EXPIRED
Post-doc position in EV biology
Study of the secretion of a novel subpopulation of extracellular vesicles
We are looking for a motivated post-doctoral scientist to join the research team “Membrane dynamics & viruses” (MDV) headed by Raphael Gaudin, part of the IRIM UMR9004 – CNRS research institute, Montpellier, France. Our lab is interested in various aspects of intracellular trafficking pathways in health and disease. In particular, we are currently studying secretion of biological entities out of the cells, including extracellular vesicles and viruses. We recently discovered a novel extracellular vesicle subtype containing Sonic Hedgehog (Shh) we called ART-EVs (Coulter, Dorobantu et al. Cell Rep, 2018) and we aim to better characterize these vesicles and their secretory route. The proposed project will take advantage of state-of-the-art imaging techniques, Crispr-Cas9 strategies and other innovative approaches mastered in the lab.
Key words: Exosomes; Extracellular vesicles; Intracellular trafficking; Membrane dynamics; Secretion
Profile and skills of the candidate: You are going to defend or already hold a PhD in Cell biology with experience in membrane trafficking. Previous experience with exosomes or extracellular vesicles is a plus. You are curious, motivated and have a problem-solving mindset. The successful candidate is expected to perform bench work and communicate his/her results through internal and external seminars. The project will be conducted in collaboration with two other labs with in vivo and proteomics expertise. The applicant is expected to speak English, while French is not a prerequisite.
Lab: The institute is located on the CNRS campus of Montpellier in the sunny south of France. We offer an internationally renowned research environment with direct access to modern infrastructures and advanced facilities for imaging and flow cytometry.
Dead line / Starting dates: Mid 2019
At a glance
The MDV team studies what viruses do to cells… Or what cells do to viruses… Well, we study the intimate virus-cell relationship
Funding
