Function
Research Director CNRS (DR2), HDR
Biosketch
Solange is a former student of Ecole Normale Supérieure. She got her PhD in the laboratory of Jacques Glowinski at Collège de France, Paris, where she studied the role of astrocytes in the protection of striatal neurons from oxidative stress. Then, she joined the team of Jean-Claude Martinou as a post-doc, at the Serono Pharmaceutical Research Institute in Geneva, Switzerland. She worked on the role of mitochondria and BCL2 family proteins in the control of apoptosis. Notably, she showed that the pro-apoptotic protein BAX can be directly activated by a BH3-only protein. Solange got a CNRS position in 2000 to join the team of Laurent Journot at the Institute of Functional Genomics in Montpellier, where she studied the transcriptional regulation of neuronal apoptosis by using DNA microarrays. She established her own team in 2005, at the Institute of Molecular Genetics of Montpellier, with the support of the CNRS ATIP program. For 19 years, her team investigated the role of a family of E3 ubiquitin-ligases, the TRIM proteins, in the regulation of neuronal apoptosis. One of these studies, on the regulation of the transcription factor ZSCAN21 by two TRIM proteins, led her to study a-synuclein expression. She then progressively focused the work of her team on the transcriptional regulation of a-synuclein in Parkinson’s disease. Solange joined the MDV team in January 2024 to study the role of viral infections in the pathogenesis of Parkinson’s disease.
Solange has been an elected member of the section 22 of the “Comité National de la Recherche Scientifique” (recruitment and evaluation of research scientists for the CNRS) between 2016 and 2021. She is a member of the board of the “Biology and Health” doctoral school in Montpellier since 2016.
My NCBI:
https://www.ncbi.nlm.nih.gov/myncbi/solange.desagher.1/bibliography/public/
Team
Membrane Dynamics & Viruses (MDV)
Contact
Email: solange.desagher(AT)irim.cnrs.fr
Phone: (+33) 04 34 35 94 25
