News

Raphaël GAUDIN publishes an article in Science Advances (IF=13.1): Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway (Deffieu et al, 2021).
How a neosynthesized protein traffics to its final destination within a cell is a challenging question to address because of the numerous intracellular trafficking routes that co-exist in the cytoplasme.


In this article, Daussy et al show that autophagy, induced by the HIV-1 envelope glycoproteins (Env), leads to an excessive production of reactive oxygen species in CD4 + T cells, responsible for their death by apoptosis. Moreover, peroxisomes, organelles involved in the control of oxidative stress, are selectively targeted by Env-mediated autophagy.


The team “Cell biology of bacterial infections” has demonstrated that the bacterial effector protein CvpF stimulates autophagy and promotes the anchoring of LC3B-II to Coxiella burnetii’s replicative niche, by deriving the function of the RAB GTPase RAB26.


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IRIM
Institut de Recherche en Infectiologie de Montpellier
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