Since 2017, the UM's I-SITE excellence programme has supported research to the tune of €20.8M. With €3.8M, the call for projects for Research Support 2022 will allow the funding of 35 projects out of the 80 proposed.

The study conducted by Maika Deffieu and Raphael Gaudin highlights the complex interactions between the hepatitis C virus (HCV) and its receptors, and in particular with occludin.

In collaboration with John Doench’s team (Broad Institute, USA), Caroline Goujon publishes in Nature Genetics (IF=41.38) an article on SARS-CoV-2.

In an article published in "Emerging Microbes & Infections" (IF= 19.56), Sébastien Nisole and his collaborators investigated the cutaneous tropism of West Nile virus (WNV) and Usutu virus (USUV), two emerging arboviruses transmitted by mosquitoes.

Wassim Daher and Laurent Kremer publish an article in Cell Chemical Biology (IF=8.2) on the glycosylation of glycopeptidolipids (GPL) required for the internalization of bacteria and their pathogenicity in Mycobacterium abscessus.

In a paper published in Nature Communications (IF=14.9), the team "Viral trafficking, restriction and innate signaling" led by Sébastien Nisole and Nathalie Arhel, in collaboration with teams from the Pasteur Institute, identifies Daxx protein as a restriction factor inhibiting SARS-CoV-2 replication in human cells.

The CNRS has extended the 80PRIME operation created in 2019 on the occasion of its 80th anniversary by creating the PRIME programme which labels "Multi-team Interdisciplinary Research Projects".

On 11 February 2022, International Women and Girls in Science Day, Abla Myriam Houmey, Julie Tram, and Lise Holsteyn, PhD students at IRIM, decided to organise a series of portraits of all the women working at IRIM, which are displayed in the lobby of the building. This exhibition will remain on display until 8 March 2022, International Women's Rights Day.

The team “Membrane Dynamics & Viruses” headed by Raphaël Gaudin, in the context of an international collaboration, publishes a review in Trends in Molecular Medicine (IF=11.95) about the possibility to target tight junctions to fight against viral neuroinvasion.

In an article published in the journal “Viruses”, Nathalie Chazal, in collaboration with Roger Miller, discusses the leading role played by virology, and more particularly retrovirology, in the major breakthroughs in molecular biology and oncology, from its origin to the puzzling discovery of antisense genes and proteins in HTLV-1 and HIV-1.

Laurent Kremer's team, in collaboration with Graham Hatfull (Pittsbrugh, USA), a specialist in mycobacteriophages, has developed an animal model using zebrafish to test the efficacy of antibacterial treatments on Mycobacterium abscessus, a mycobacterium very similar to those responsible for tuberculosis or leprosy.

Interferons are our first line of defense against invading viruses. However, viruses encode effector proteins that can modulate human interferon responses.