Raphaël GAUDIN publishes an article in Science Advances (IF=13.1): Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway (Deffieu et al, 2021).
How a neosynthesized protein traffics to its final destination within a cell is a challenging question to address because of the numerous intracellular trafficking routes that co-exist in the cytoplasme.

In this review published in Trends in Cell Biology (IF = 16), the authors Raphael Gaudin (IRIM, CNRS – University of Montpellier) and Jacky Goetz (INSERM – University of Strasbourg) describe how cell biologists and virologists developed relevant in vivo models to study the molecular mechanisms governing viral dissemination.

In this article, Daussy et al show that autophagy, induced by the HIV-1 envelope glycoproteins (Env), leads to an excessive production of reactive oxygen species in CD4 + T cells, responsible for their death by apoptosis. Moreover, peroxisomes, organelles involved in the control of oxidative stress, are selectively targeted by Env-mediated autophagy.

An interdisciplinary work led by the team of Laura Picas in collaboration with Adrian Carretero-Genevrier’s team (Institue of Electronics and Systems) published in ACS Appl. Mater. Interfaces (IF = 8.76).

In a work published in PNAS (IF=9.35), the Matteo Bonazzi’s team “Cell Biology of Bacterial Infections” unveils the existence of new C. burnetii effector proteins with eukaryotic-like features (EUGENs).

The discrimination between the nodulation factor (friend) and chitin (foe) by legumes is ensured by a family of receptors called LysM-RLK.

In this review published in “Nature Reviews Microbiology” (IF=34.65), Johansen, Herrmann and Kremer discuss the infection process, host interactions, mechanisms of drug resistance and drug development in M. abscessus.

The team “Cell biology of bacterial infections” has demonstrated that the bacterial effector protein CvpF stimulates autophagy and promotes the anchoring of LC3B-II to Coxiella burnetii’s replicative niche, by deriving the function of the RAB GTPase RAB26.

In a work published in Science Advances (IF=12.8), Sébastien Nisole and collaborators unveil a new mechanism for the regulation of the interferon response in plasmacytoid dendritic cells (pDCs).

An ERC Proof Of Concept grant awarded to Caroline Goujon for the Flu-Attack project led by Olivier Moncorge at IRIM, in the "Interferon and Antiviral Restriction" team.

In a work published in Nature Microbiology (IF=14.6), Nathalie Arhel and collaborators reveal how HIV-1 uncoating and nuclear import are coordinated by a nuclear pore transport protein, Transportin-1 (TRN-1).

The work of Delphine Muriaux and Cyril Favard about HIV-1 assembly published in Science Advances (IF=12.8).