Wassim Daher and Laurent Kremer publish an article in Cell Chemical Biology (IF=8.2) on the glycosylation of glycopeptidolipids (GPL) required for the internalization of bacteria and their pathogenicity in Mycobacterium abscessus.

In a paper published in Nature Communications (IF=14.9), the team "Viral trafficking, restriction and innate signaling" led by Sébastien Nisole and Nathalie Arhel, in collaboration with teams from the Pasteur Institute, identifies Daxx protein as a restriction factor inhibiting SARS-CoV-2 replication in human cells.

The CNRS has extended the 80PRIME operation created in 2019 on the occasion of its 80th anniversary by creating the PRIME programme which labels "Multi-team Interdisciplinary Research Projects".

On 11 February 2022, International Women and Girls in Science Day, Abla Myriam Houmey, Julie Tram, and Lise Holsteyn, PhD students at IRIM, decided to organise a series of portraits of all the women working at IRIM, which are displayed in the lobby of the building. This exhibition will remain on display until 8 March 2022, International Women's Rights Day.

The team “Membrane Dynamics & Viruses” headed by Raphaël Gaudin, in the context of an international collaboration, publishes a review in Trends in Molecular Medicine (IF=11.95) about the possibility to target tight junctions to fight against viral neuroinvasion.

In an article published in the journal “Viruses”, Nathalie Chazal, in collaboration with Roger Miller, discusses the leading role played by virology, and more particularly retrovirology, in the major breakthroughs in molecular biology and oncology, from its origin to the puzzling discovery of antisense genes and proteins in HTLV-1 and HIV-1.

Laurent Kremer's team, in collaboration with Graham Hatfull (Pittsbrugh, USA), a specialist in mycobacteriophages, has developed an animal model using zebrafish to test the efficacy of antibacterial treatments on Mycobacterium abscessus, a mycobacterium very similar to those responsible for tuberculosis or leprosy.

Interferons are our first line of defense against invading viruses. However, viruses encode effector proteins that can modulate human interferon responses.

Alarmins are extracellular mediators known to amplify the host inflammatory response, notably upon pathogenic challenge. The intracellular functions of alarmins in this context are, however, poorly studied.

This study, about imaging the translation of mRNA into proteins in the developing Drosophila embryo, is a federative work involving the three biology laboratories located on the Montpellier CNRS site, Route de Mende.

In this article published in Journal of Virology, the “interferon and antiviral restriction” team led by Caroline Goujon, studied the establishment and the role of the interferon response in the control of SARS-CoV-2 replication in human epithelial pulmonary cells, which are the main targets for SARS-CoV-2.

Raphaël GAUDIN publishes an article in Science Advances (IF=13.1): Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway (Deffieu et al, 2021).
How a neosynthesized protein traffics to its final destination within a cell is a challenging question to address because of the numerous intracellular trafficking routes that co-exist in the cytoplasme.