In their study published in Nature Communications, Zakia Morichaud (Team Brodolin) and colleagues demonstrate howacromoleculesan self-assemble into complex structures and regulate gene expression. Focusing here on the RNA polymerase of Mycobacterium tuberculosis.
Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Morichaud Z, Trapani S, Vishwakarma RK, Chaloin L, Lionne C, Lai-Kee-Him J, Bron P, Brodolin K. . Nat Commun. 2023 Jan 30;14(1):484. doi: 10.1038/s41467-023-36113-y. PMID: 36717560; PMCID: PMC9886945.
