AMI – Autophagy Machinery in Infections

Publication (2020-2025)

2025

2024

1. Feuillard J, Couston J, Benito Y, Hodille E, Dumitrescu O, Blaise M. Biochemical and structural characterization of a class A β-lactamase from Nocardia cyriacigeorgica. Acta Crystallogr F Struct Biol Commun. 2024 Jan 1;80(Pt 1):13-21.
2. Paris T, Kiss A, Signor L, Lutfalla G, Blaise M, Boeri Erba E, Chaloin L, Yatime L. The IbeA protein from adherent invasive Escherichia coli is a flavoprotein sharing structural homology with FAD-dependent oxidoreductases. FEBS J. 2024 Jan;291(1):177-203.
3. Pradel B, Cantaloube G, Villares M, Deffieu MS, Robert-Hebmann V, Lucansky V, Faure M, Chazal N, Gaudin R, Espert L. LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes. Autophagy. (2024) Apr 7:1-12.
4. Boulay A, Quevarec E, Malet I, Nicastro G, Chamontin C, Perrin S, Henriquet C, Pugnière M, Courgnaud V, Blaise M, Marcelin AG, Taylor IA, Chaloin L, Arhel NJ. A new class of capsid-targeting inhibitors that specifically block HIV-1nuclear import. EMBO Mol Med. 2024 Nov;16(11):2918-2945.
5. Villares M, Espert L, Daussy CF. Peroxisomes are underappreciated organelles hijacked by viruses. Trends in Cell Biology. (2024) Dec 11:S0962-8924(24)00248-4.

2023

1. McKellar J, Arnaud-Arnould M, Chaloin L, Tauziet M, Arpin-André C, Pourcelot O, Blaise M, Moncorgé O, Goujon C. An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses. J Biol Chem. 2023 Jan;299(1):102747.
2. Ung KL, Poussineau C, Couston J, Alsarraf HMAB, Blaise M. Crystal structure of MAB_4123, a putative flavin-dependent monooxygenase from Mycobacterium abscessus. Acta Crystallogr F Struct Biol Commun. 2023 May 1;79(Pt 5):128-136.
3. Schatz M, Marty L, Ounadjela C, Tong PBV, Cardace I, Mettling C, Milhiet PE, Costa L, Godefroy C, Pugnière M, Guichou JF, Mesnard JM, Blaise M, Beaumelle B. A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity. J Virol. 2023 Apr 27;97(4):e0027823.
4. Papin L, Lehmann M, Lagisquet J, Maarifi G, Robert-Hebmann V, Mariller C, Guerardel Y, Espert L, Haucke V, Blanchet FP.The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells. Int J Mol Sci. 2023 May 19;24(10):9008.
5. Claviere M, Lavedrine A, Lamiral G, Bonnet M, Verlhac P, Petkova DS, Espert L, Duclaux-Loras R, Lucifora J, Rivoire M, Boshetti G, Nancey S, Rozières A, Vret C, Faure M. Measle virus-imposed remodeling of the autophagy machinery determines the outcome of bacterial coinfection. Autophagy (2023) Aug 9;1-1.
6. Couston J, Guo Z, Wang K, Gourdon P, Blaise M. Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs. Curr Res Struct Biol. 2023 Nov 8;6:100109.
7. Marty L, Pastre C, Blaise M, Beaumelle B. Mécanisme d’association de la protéine Tat du VIH à la particule virale [Mechanism enabling HIV Tat association with viral particles]. Med Sci (Paris). 2023 Dec;39(12):915-917.

2022

1. Bonaventure B, Rebendenne A, Chaves Valadão AL, Arnaud-Arnould M, Gracias S, Garcia de Gracia F, McKellar J, Labaronne E, Tauziet M, Vivet-Boudou V, Bernard E, Briant L, Gros N, Djilli W, Courgnaud V, Parrinello H, Rialle S, Blaise M, Lacroix L, Lavigne M, Paillart JC, Ricci EP, Schulz R, Jouvenet N, Moncorgé O, Goujon C. The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses. EMBO Rep. 2022 Nov 7;23(11):e54061.
2. Alsarraf HMAB, Ung KL, Johansen MD, Dimon J, Olieric V, Kremer L, Blaise M. Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase. FEBS Lett. 2022 Jun;596(12):1516-1532.
3. Ung KL, Alsarraf H, Kremer L, Blaise M. MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs. Protein Expr Purif. 2022 Mar;191:106014.

2021

1. Miller RH., Zimmer A., Moutot G., Mesnard JM. and Chazal N. Viruses. (2021). Retroviral Antisens Transcripts and Genes: 33 Years after First Predicted, a Silent Retroviral Revolution? Viruses (2021) 13(11), 2221.
2. Coralie F Daussy, Mathilde Galais, Baptiste Pradel, Véronique Robert-Hebmann, Sophie Sagnier, Sophie Pattingre, Martine Biard-Piechaczyk and Lucile Espert. HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death. Autophagy. (2021) Sep;17(9):2465-2474
3. Savoret J., Mesnard J.-M., Gross A., and Chazal N. Antisense transcripts and antisense protein : a new perspective on human immunodeficiency virus type 1. Front. Microbiol. (2021) 11: 625941./li>
4. Ragimbeau R., El Kebriti L., Fourgous E., Boulahtouf A., Arena G., Espert L., Houédé N., Gongora C. and Pattingre S. BAG6 is a new receptor of mitophagy that induces mitochondrial fragmentation and PINK1/PARKIN signaling. FASEB J. (2021) Feb;35(2):e21361
5. Daniel J. Klionsky,…. Lucile Espert,…. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4^th Edition). Autophagy. 2021 Feb 8;1-382.
6. Romina Cabrera-Rodríguez, Silvia Pérez-Yanes, Judith Estévez-Herrera, Daniel Márquez-Arce, Cecilia Cabrera, Lucile Espert, Julia Blanco, Agustin Valenzuela-Fernández. (2021) The Interplay of HIV and Autophagy in Early Infection. Front Microbiol.  Apr 28;12:661446.
7. Charlotte Martinat, Arthur Cormier, Joёlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini. SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells. Nature Communications. Jul 28;12(1):4582.
8. Chazal N. Coronavirus, the King Who Wanted More Than a Crown: From Common to the Highly Pathogenic SARS-CoV-2, Is the Key in the Accessory Genes? Front Microbiol. (2021) Jul 14;12:682603.
9. Arnaud-Arnould M, Tauziet M, Moncorgé O, Goujon C, Blaise M. Crystal structure of the TLDc domain of human NCOA7-AS. Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):230-237.
10. Gysel K, Laursen M, Thygesen MB, Lironi D, Bozsóki Z, Hjuler CT, Maolanon NN, Cheng J, Bjørk PK, Vinther M, Madsen LH, Rübsam H, Muszyński A, Ghodrati A, Azadi P, Sullivan JT, Ronson CW, Jensen KJ, Blaise M, Radutoiu S, Stougaard J, Andersen KR. Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2111031118.

2020

1. Savoret J., Chazal N., Moles J.-P., Tuaillon E., Boufassa F., Meyer L., Lecuroux F., Lambotte O., Van de Perre P., Mesnard J.-M., and Gross A. (2020) A pilot study of the humoral response against the AntiSense Protein (ASP) in HIV-1-infected patients. Front. Microbiol. 11: 20.
2. Ung KL, Kremer L, Blaise M. Structural analysis of the N-acetyltransferase Eis1 from Mycobacterium abscessus reveals the molecular determinants of its incapacity to modify aminoglycosides. Proteins. 2020 Jan;89(1):94-106
3. de Ruyck J, Dupont C, Lamy E, Le Moigne V, Biot C, Guérardel Y, Herrmann JL, Blaise M, Grassin-Delyle S, Kremer L, Dubar F. Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors. Chemistry Open. 2020 Mar 20;9(3):351-365.
4. Blaise M, Kremer L. Self-control of vitamin K₂ production captured in the crystal. J Biol Chem. 2020 Mar 20;295(12):3771-3772.
5. Chazal N, de Rocquigny H, Roussel P, Bouaziz S, Barré-Sinoussi F, Delfraissy JF, Darlix JL. The three lives of Pierre Boulanger. Retrovirology. (2020) Apr 30;17(1):9.
6. Bozsoki Z, Gysel K, Hansen SB, Lironi D, Krönauer C, Feng F, de Jong N, Vinther M, Kamble M, Thygesen MB, Engholm E, Kofoed C, Fort S, Sullivan JT, Ronson CW, Jensen KJ, Blaise M, Oldroyd G, Stougaard J, Andersen KR, Radutoiu S. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science. 2020. Aug 7;369(6504):663-670.
7. Faïon L, Djaout K, Frita R, Pintiala C, Cantrelle FX, Moune M, Vandeputte A, Bourbiaux K, Piveteau C, Herledan A, Biela A, Leroux F, Kremer L, Blaise M, Tanina A, Wintjens R, Hanoulle X, Déprez B, Willand N, Baulard AR, Flipo M. Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening. Eur J Med Chem. 2020 Aug 15;200:112440.
8. Baptiste Pradel, Véronique Robert-Hebmann, Lucile Espert. Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses. Frontiers in Immunology. (2020) Oct 6;11:578038.
9. Wong JEMM, Blaise M. Report of false positives when using zymography to assess peptidoglycan hydrolytic activity of an endopeptidase with multiple LysM domains. Biochimie. 2020. Oct;177:25-29.
10. Küssau T, Van Wyk N, Johansen MD, Alsarraf HMAB, Neyret A, Hamela C, Sørensen KK, Thygesen MB, Beauvineau C, Kremer L, Blaise M. Functional Characterization of the N-Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus. Cells. 2020 Nov 4;9(11):2410.

Publications Mougel group : Pubmed publication list