Muriaux Delphine

Fonction

Responsable Equipe MDVA / Directrice du CEMIPAI (UAR3725 CNRS)

Equipe

Domaines Membranaires et Assemblage Viral

Grade

Directrice de Recherche CNRS 1er classe

Parcours

HDR Virologie Université Lyon 1

Doctorat Biologie Cellulaire et Moléculaire Université Pierre et Marie Curie

Contact

email : delphine.muriaux_at_irim.cnrs.fr

Tél : 04 34 35 94 62

Signification Publications

*Co Last

HIV-1 Assembly

HIV-1 diverts actin debranching mechanisms for particle assembly and release in CD4 T lymphocytes R. Dibsy, E. Bremaud, J. Mak, C. Favard, D. Muriaux, Nat. Commun. (2023)
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53. K. Inamdar, F-C. Tsai, A. de Poret, R. Dibsy, J. Manzi,P. Merida, R. Muller, P. Lappalainen, P. Roingeard, J. Mak, P. Bassereau,C. Favard, D.Muriaux*. eLife (2021)
HIV-1 Gag specifically restricts PI(4,5)P₂ and cholesterol mobility in living cells creating a nanodomain platform for virus assembly. C. Favard#, J Chojnacki#, P. Merida, N. Yandrapalli, J. Mak, C. Eggeling*, D. Muriaux*, Science Adv. (2019)
Single molecule localisation microscopy reveals how HIV-1 Gag proteins sense membrane virus assembly sites in living host CD4 T cells. Floderer C., Masson JB., Boilley E., Georgeault S., Merida P., El Beheiry M., Dahan M., Roingeard P., Sibarita JB., Favard C.* Muriaux D*. Sci. Reports (2018)
The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101. S.E. El Meshri, E. Boutant, A. Mouhand, A. Thomas, V. Larue, L. Richert, V. Vivet-Boudou, Y. Mély, C. Tisné*, D. Muriaux*, H. de Rocquigny*, Biochem. Biophys. Acta, (2018)
Self assembly of HIV-1 Gag protein on lipid membranes generates PI(4,5)P2/Cholesterol nanoclusters. Yandrapalli N, Lubart Q, Tanwar HS, Picart C, Mak J, Muriaux D*, Favard C*. Sci. Reports (2016)

SARS-CoV2

F-actin nanostructures rearrangements and regulation are essential for SARS-CoV2 particle production in host pulmonary cells. J. Swain, P. Merida, K. Rubio, D. Bracquemond, A. Neyret, I. Aguilar-Ordoñez, S. Günther, G. Barreto, D. Muriaux, iScience (2023)
Biochemistry-informed design selects potent siRNAs against SARS-CoV-2 É. Houbron, S. Mockly, S. Rafasse, N. Gros, D. Muriaux, H. Seitz, RNA Biol. (2023)
The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2 S. Assou, E. Ahmed, L. Morichon, A. Nasri, F. Foisset, C. Bourdais, N. Gros, S. Wong, A. Petit, I. Vachier, D. Muriaux, A. Bourdin, J. De Vos, Int J Mol Sci. (2023)
The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling. Laplantine E, Chable-Bessia C, Oudin A, Swain J, Soria A, Merida P, Gourdelier M, Mestiri S, Besseghe I, Bremaud E, Neyret A, Lyonnais S, Favard C, Benaroch P, Hubert M, Schwartz O, Guerin M, Danckaert A, Del Nery E, Muriaux D,* Weil R.*. iScience (2022)
Optimized production and fluorescent labeling of SARS-CoV-2 virus-like particles. Gourdelier M, Swain J, Arone C, Mouttou A, Bracquemond D, Merida P, Saffarian S, Lyonnais S, Favard C, Muriaux D. Sci. Reports (2022)
Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy. Salehi H, Ramoji A, Mougari S, Merida P, Neyret A, Popp J, Horvat B, Muriaux D*, Cuisinier F*. Commun. Chemistry (2021)
Low selectivity index of ivermectin and macrocyclic lactones on SARS-CoV2 replication in vitro argues against their therapeutic use for COVID-19 Chable-Bessia C., Boullé A., J. Swain, M. Hénaut, P. Merida, N. Gros, A. Makinson, S. Lyonnais, C.B. Chesnais, D. Muriaux. COVID (2021)
Betacoronavirus Assembly: Clues and Perspectives for Elucidating SARS-CoV-2 Particle Formation and Egress. Bracquemond D, Muriaux D., mBio (2021)

Other viruses

Tetraspanin CD82 maintains HTLV-1 biofilm polarization and is required for efficient viral transmission C. Arone, S. Martial, J. Burlaud-Gaillard, M-I Thoulouze, P. Roingeard, H. Dutartre, D. Muriaux, mBio (2023)
Specific targeting and clustering of Phosphatidylserine lipids by RSV M protein is critical for virus particle production J. Swain, M. Bierre, L. Veyrié, C-A. Richard, J-F. Eleouet, D. Muriaux*, M. Bajorek*. J. Biol. Chem. (2023)
Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus. Kerviel A, Dash S, Moncorgé O, Panthu B, Prchal J, Décimo D, Ohlmann T, Lina B, Favard C, Decroly E, Ottmann M, Roingeard P, Muriaux D. Plos One (2016)

Tools

Label-Free Single Nanoparticle Identification and Characterization in Demanding Environment, Including Infectious Emergent Virus. M-C. Nguyen, P. Bonnaud, R. Dibsy, G. Maucourt, S. Lyonnais, D. Muriaux, P. Bon, Small (2023)
Validation of Flavivirus Infectious Clones Carrying Fluorescent Markers for Antiviral Drug Screening and Replication Studies. L Cherkashchenko, N. Gros, A. Trausch, A. Neyret, M. Hénaut, G. Dubois, M. Villeneuve, C. Chable-Bessia, S. Lyonnais, A. Merits, D.Muriaux. Front Microbiol. (2022)
Atomic force microscopy analysis of native infectious and inactivated SARS-CoV-2 virions. S Lyonnais, M Henaut, A Neyret, P Merida, C. Cazevieille, N Gros, C Chable-Bessia, D.Muriaux. Sci. Reports (2021)

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