Publications

Principales publications de l’IRIM dans des journaux avec un comité de lecture

2022

Rebendenne A., Roy P., Bonaventure B., Chaves Valadão A.L., Desmarets L., Arnaud-Arnould M., Rouillé Y., Tauziet M., Giovannini D., Touhami J., Lee Y., DeWeirdt P., Hegde M., Urbach S., Koulali K.E., de Gracia F.G., McKellar J., Dubuisson J., Wencker M., Belouzard S., Moncorgé O., Doench J.G., and Goujon C. (2022) Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nat. Genet. 54: 1090-1102.
Martin M.F., Maarifi G., Abiven H., Seffals M., Mouchet N., Beck C., Bodet C., Lévèque N., Arhel N.J., Blanchet F.P., Simonin Y, and Nisole S. (2022) Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus. Emerg. Microbes Infect. 11: 761-774.
Deffieu M.S., Clément C.M.H., Dorobantu C.M., Partiot E., Bare Y., Faklaris O., Rivière B., Ayala-Nunez N.V., Baumert T.F., Rondé P., Mély Y., Lucansky V., and Gaudin R. (2022) Occluding stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization. Hepatology. 76(4): 1164-1179.
Bonaventure B., Rebendenne A.,Chaves Valadão A.L., Arnaud-Arnould M., Gracias S., Garcia de Gracia F., McKellar J., Labaronne E., Tauziet M., Vivet-Boudou V., Bernard E., Briant L. Gros N., Djilli W., Courgnaud V., Parrinello H., Rialle S., Blaise M., Lacroix L., Lavigne M., Paillart J.C., Ricci E.P., Schulz R., Jouvenet N., Moncorgé O., and Goujon C. (2022) The DEAD box RNA helicase DDX42 is an intrincic inhibitor of positive-strand RNA viruses. EMBO Rep. 23(11): e54061.
El Alaoui F., Casuso I., Sanchez-Fuentes D., Arpin-André C., Rathar R., Baecker V., Castro A., Lorca T., Viaud J., Vassilopoulos S., Carretero-Genevrier A., and Picas L. (2022) Structural organization and dynamics of FCHo2 docking on membranes. Elife. 11: e73156.
Daher W., Leclercq L.D., Johansen M.D., Hamela C., Karam J., Trivelli X., Nigou J., Guérardel Y., and Kremer L. (2022) Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus. Cell Chem. Biol. 29: 910-924.
Maarifi G., Martin M.F., Zebboudj A., Boulay A., Nouaux P., Fernandez J., Lagisquet J., Garcin D., Gaudin R., Arhel N.J., and Nisole S. (2022) Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. Cell Chem. Biol. 29: 1113-1125.
Alcaraz M., Sharma B., Roquet-Banères F., Conde C., Cochard T., Biet F., Kumar V., and Kremer L. (2022) Designing quinoline-isoniazid hybrids as potent anti-tubercular agents inhibiting mycolic acid biosynthesis. Eur. J. Med. Chem. 239: 114531.
Gaudin R., Brychka D., Sips G.J., and Ayala-Nunez V. (2022) Targeting tight junctions to fight against viral neuroinvasion. Trends Mol. Med. 28(1): 12-24.
Lagune M., Le Moigne V., Johansen M.D., Vásquez Sotomayor F., Daher W., Petit C., Cosentino G., Paulowski L., Gutsmann T., Wilmanns M., Maurer F.P., Herrmann J.L., Girard-Misguich F., and Kremer L. (2022) The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness. PLoS Pathog. 18: e1010771.
Alcaraz M., Roquet-Banères F., Leon-Icaza S.A., Abendroth J., Boudehen Y.M., Cougoule C., Edwards T.E., and Kremer L. (2022) Efficacy and mode of action of a direct inhibitor of Mycobacterium abscessus InhA. ACS Infect. Dis. 8(10): 217162186.
Tury S., Giovannini D., Ivanova S., Touhami J., Courgnaud V., and Battini J.-L. (2022) Identification of copper transporter 1 as a receptor for feline endogenous retrovirus ERV-DC14. J. Virol. 96(12): e0022922.
Bonaventure B. and Goujon C. (2022) DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections. J. Gen. Virol. 103(8): e0022922.
Occhialini A., Hofreuter D., Ufermann C.M., Al Dahouk S., and Köhler S. (2022) The retrospective on atypical Brucella microti species leads to novel definitions. Microorganisms 10(4): 813.
Gourdelier M., Swain J., Arone C., Mouttou A., Bracquemond D., Merida P., Saffarian S., Lyonnais S., Favard C., and Muriaux D. (2022) Optimized production and fluorescent labeling of SARS-CoV-2 virus-like particles. Sci. Rep. 12(1): 14651.
Alsarraf H., Ung K.L., Johansen M.D., Dimon J., Olieric V., Kremer L., and Blaise M. (2022) Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase. FEBS Lett. 596: 1516-1532.
Neyret A., Bernard E., Aïqui-Reboul-Paviet O., Bakhache W., Eldin P., Chaloin L., and Briant L. (2022) Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain. Front. Cell. Infect. Microbiol. 12(10): 958176.
Tram J., Mesnard J.-M., and Péloponèse J.-M. (2022) Alternative RNA splicing in cancer: what about adult T-cell leukemia. Front. Immunol. 13: 959382.
Ung K.L., Alsarraf H., Kremer L., and Blaise M. (2022) MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidics. Protein Expr. Purif. 191: 106014.
Brémaud E., Favard C., and Muriaux D. (2022) Deciphering the assembly of enveloped viruses using model lipid membranes. Membranes 12: 441.
Jansen M. and Beaumelle B. (2022) How palmitoylation affects trafficking and signaling of membrane receptors. Biol. Cell. 114(2): 61-72.
De Poret A., Dibsy R., Merida P., Trausch A., Inamdar K., and Muriaux D. (2022) Extracellular vesicles containing the I-BAR protein IRSp53 are released from the cell plasma membrane in an Arp2/3 dependent manner. Biol. Cell. 114(10) :259-275.
Kam J.Y., Hortle E., Krogman E., Warner S.E., Wright K., Luo K., Cheng T., Manuneedhi Cholan P., Kikuchi K., Triccas J.A., Britton W.J., Johansen M.D., and Kremer L., Oehlers S.H. (2022) Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish. Nat. Commun. 13(1): 952.

2021

Daussy C.F., Galais M., Pradel B., Robert-Hebmann V., Sagnier S., Pattingre S., Biard-Piechaczyk M., and Espert L. (2021) HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death. Autophagy 17(9): 2465-2474.
De la Garza-Gaecia J.A., Ouahrani-Bettache S., Lyonnais S., Ornelas-Eusebio E., Freddi L., Occhialini A., Al Dahouk S., and Köhler S. (2021) Comparative genome-wide transcriptome analysis of Brucella suis and Brucella microti under acid stress at pH 4.5: cold shock protein CspA and Dps are associated with acid resistance of B. microti. Front. Microbiol. 12: 794535.
Jouvenet N.*, Goujon C.*, and Banerjee A.* (2021) Clash of the titans: interferons and SARS-CoV-2. Trends Immunol. 42(12): 1069-1072. *Co-corresponding authors.
Bracquemond and Muriaux D. (2021) Betacoronavirus assembly: clues and perspectives for elucidating SARS-CoV-2 particle formation and egress. mBio. 12(5): e0237121.
Johansen M.D., Alcaraz M., Dedrick R.M., Roquet-Banères F., Hamela C., Hatfull G.F., and Kremer L. (2021) Mycobacteriophage-antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus. Dis. Model. Mech. 14(9): dmm049159.
Miller R.H., Zimmer A., Moutot G., Mesnard J.-M., and Chazal N. (2021) Retroviral antinsense transcripts and genes: 33 years after first predicted, a silent retroviral revolution? Viruses 13(11): 2221.
Chamontin C., Bossis G., Nisole S., Arhel N.J., and Maarifi G. and (2021) Regulation of viral restriction by post-translation modifications. Viruses 13(11): 2197.
Chazal N. (2021) Coronavirus, the king who wanted more than a crown: from common to the highly pathogenic SARS-CoV-2, is the key in the accessory genes? Front. Microbiol. 12: 682603.
Bienvenu A., Martinez E., and Bonazzi M. (2021) Undercover agents of infection: The stealth strategies of T4SS-equpped bacterial pathogens. Toxins 13(10): 713.
Siadous F.A., Cantet F., Van Schaik E., Burette M., Allombert J., Lakhani A., Bonaventure B., Goujon C., Samuel J., Bonazzi M., and Martinez E. (2021) Coxiella effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence. Autophagy 17(3):706-22.
Maarifi G., Lagisquet J., Hertel Q., Bonaventure B., Chamontin C., Fuchs K., Moncorgé O., Tauziet M., Mombled M., Papin L., Molès J.-P., Bodet C., Lévèque N., Gross A., Arhel N., Nisole S., Van de Perre P., Goujon C, and Blanchet F.P. (2021) Alarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells. EMBO J. Jun 14: e106540.
Deffieu M.S., Cesonyte I, Delalande F., Boncompain G., Dorobantu C., Song E., Lucansky V., Hirschler A., Cianferani S., Perez F, Carapito C., and Gaudin R. (2021) Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway. Sci. Adv. 7(2): eaba7803.
Fernandez J., Hassen-Khodja C., Georget V., Rose T., Jacob Y., Janin Y.L., Nisole S., Vidalain P.O., and Arhel NJ. (2021) Measuring the subcellular compartmentalization of viral infections by protein complementation assay. Proc. Natl. Acad. Sci. USA.118(2): e2010524118.
Inamdar K., Tsai F.-C., Dibsy R., De Poret A., Manzi J., Merida P., Muller R., Lappalainen P., Roingeard P., Mak J., Bassereau P., Favard C., and Muriaux D. (2021) Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53. eLife 10: e67321.
Bauby H., Ward C.C., Hugh-White R., Swanson C.M., Schulz R.*, Goujon C.*, and Malim M.H.* (2021) HIV-1 Vpr induces widespread transcriptomic changes in CD4+ T cells early postinfection. mBio. 12(3): e0136921. *Co-contributing authors.
Brodolin K. and Morichaud Z. (2021) Region 4 of the RNA polymerase σ subunit counteracts pausing during initial transcription. J. Biol. Chem. 296: 100253.
Rebendenne A., Valadão A.L.C., Tauziet M., Maarifi G., Bonaventure B., McKellar J., Planès R., Nisole S., Arnaud-Arnould M., Moncorgé O, Goujon C. (2021) SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells. J. Virol. 95(18): e02415-20.
Lyonnais S., Hénaut M., Neyret A., Merida P., Cazevieille C., Gros N., Chable-Bessia C., and Muriaux D. (2021) Atomic force microscopy analysis of native infectious and inactivated SARS-CoV-2 virions. Sci. Rep. 11(1): 11885.
Johansen M.D., Shalini, Kumar S., Raynaud C., Quan D.H., Britton W.J., Hansbro P.M., Kumar V., and Kremer L. (2021) Biological and biochemical evaluation of isatin-isoniazid hybrids as bactericidal candidates against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. May 10; AAC.00011-21.
Gaudin R. and Goetz J.G. (2021) Tracking mechanisms of viral dissemination in vivo. Trends Cell Biol. 31(1): 17-23.
Savoret J., Mesnard J.-M., Gross A., and Chazal N. (2021) Antisense transcripts and antisense protein: A new perspective on human immunodeficiency virus type 1. Front. Microbiol. 11: 625941.
McKellar J., Rebendenne A., Wencker M., Moncorgé O., and Goujon C. (2021) Mammalian and avian host cell Influenza A restriction factors. Viruses 13(3): 522.
Dufourt J., Bellec M., Trullo A., Dejean M., De Rossi S., Favard C., and Lagha M. (2021) Imaging translation dynamics in live embryos reveals spatial heterogeneities. Science 372(6544): 840-44.

2020

Woringer M., Izeddin I., Favard C.*, and Berry H.* (2020) Anomalous subdiffusion in living cells: Bridging the gap between experiments and realistic models through collaborative challenges. Front. Phys. 8: 134. *Co-corresponding authors.
Daussy C.F., Galais M., Pradel B., Robert-Hebmann V., Sagnier S., Pattingre S., Biard-Piechaczyk M., and Espert L. (2020) HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death. Autophagy Oct 19: 1-10.
Sansen T., Sanchez-Fuentes D., Rathar R, Colom-Diego A., El Alaoui F., Viaud J., Macchione M., de Rossi S., Matile S., Gaudin R., Bäcker V., Carretero-Genevrier A., and Picas L. (2020) Mapping cell membrane organization and dynamics using soft nanoimprint lithography. ACS Appl. Mater Interfaces 12(26): 29000-12.
Siadous F.A., Cantet F., Van Schaik E., Burette M., Allombert J., Lakhani A., Bonaventure B., Goujon C., Samuel J., Martinez E., and Bonazzi M. (2020) Coxiella effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence. Autophagy Mar 1: 1-17.
Gaudin R. and Goetz J.G. (2020) Tracking mechanisms of viral dissemination in vivo. Trends Cell Biol. In press.
Johansen M.D., Herrmann J.L., and Kremer L. (2020) Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus. Nat. Rev. Microbiol. 18(7): 392-407.
Burette M., Allombert J., Lambou K., Maarifi G., Nisole S., Di Russo Case E., Blanchet F.P., Hassen-Khodja C., Cabantous S., Samuel J., Martinez E., and Bonazzi M. (2020) Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein. Proc. Natl. Acad. Sci. USA.117(24): 13708-18.
Trottier J., Darques R., Ait Mouheb N., Partiot E., Bakhache W., Deffieu M.S., and Gaudin R. (2020) Post-lockdown detection of SARS-CoV-2 RNA in the wastewater of Montpellier, France. One Health 10: 100157.
Sa Ribero M., Jouvenet N., Dreux M.,and Nisole S. (2020) Interplay between SARS-CoV-2 and the type I interferon response. Plos. Pathog. 16(7): e1008737.
Ayala-Nunez N.V. and Gaudin R. (2020) A viral journey to the brain: Current considerations and future developments. Plos. Pathog. 16(5): e1008424.
Johansen M.D. and Kremer L. (2020) Large extracellular cord formation in a zebrafish model of Mycobacterium kansasii infection. J. Infect. Dis. 222(6): 1046-50.
Johansen M.D., Daher W., Roquet-Baneres F., Raynaud C., Alcaraz M., Maurer F.P., and Kremer L. (2020) Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus. Antimicrob. Agents Chemother. 64: e00363-20.
Raynaud C., Daher W., Roquet-Baneres F., Johansen M.D., Stec J., Onajole O.K., Ordway D., Kozikowski A.P., and Kremer L. (2020) Synergistic interactions of Indole-2-Carboxamides and b-lactam antibiotics against Mycobacterium abscessus. Antimicrob. Agents Chemother. 64: e02548-19.
Richard M., Gutiérrez A.V., and Kremer L. (2020) Dissecting erm(41)-mediated macrolide-inducible resistance in Mycobacterium abscessus. Antimicrob. Agents Chemother. 64: e01879-19.
Daher W., Leclercq L.D., Viljoen A., Karam J., Dufrêne Y.F., Guérardel Y., and Kremer L. (2020) O-methylation of the glycopeptidolipid acyl chain defines surface hydrophobicity of Mycobacterium abscessus and macrophage invasion. ACS Infect. Dis. 6(10): 2756-70.
Raynaud C., Daher W., Johansen M.D., Roquet-Baneres F., Blaise M., Onajole O.K., Kozikowski A.P., Herrmann J.L., Dziadek J., Gobis K., and Kremer L. (2020) O-methylation of the glycopeptidolipid acyl chain defines surface hydrophobicity of Mycobacterium abscessus and macrophage invasion. ACS Infect. Dis. 6(2): 324-37.
Mougel M., Akkawi C., Chamontin C., Feuillard J., Pessel-Vivares L., Socol M., and Laine S. (2020) NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA. RNA biol. 17(4): 528-38.
Bakhache W., Neyret A., Bernard E., Merits A., and Briant L. (2020) Palmitoylated cysteines in Chikungunya virus nsP1 are critical for targeting to cholesterol-rich plasma membrane microdomains with functional consequences for viral genome replication. J. Virol. 94(10): e02183-19.
López-Sánchez U., Tury S., Nicolas G., Wilson M.S., Jurici S., Ayrignac X., Courgnaud V., Saiardi A., Sitbon M.*, and Battini J.-L.* (2020) Interplay between primary familial brain calcification-associated SLC0A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis. J. Biol. Chem. 295(28): 9366-78. *Co-corresponding authors.
Martinez E., Huc-Brandt S., Brelle S., Allombert J., Cantet F., Gannoun-Zaki L., Burette M., Martin M., Letourneur F., Bonazzi M.*, and Molle V.* (2020) The secreted protein kinase CstK from Coxiella burnetiid influences vacuole development and intercats with the GTPase-activating host protein TBC1D5. J. Biol. Chem. 295(21): 7391-7403. *Co-corresponding authors.
Blaise M. and Kremer L. (2020) Self-control of vitamin K2 production captured in the crystal. J. Biol. Chem. 295(12): 3771-72.
Savoret J., Chazal N., Moles J.-P., Tuaillon E., Boufassa F., Meyer L., Lecuroux C., Lambotte O., Van de Perre P., Mesnard J.-M., and Gross A. (2020) A pilot study of the humoral response against the antisense protein (ASP) in HIV-1-infected patients. Front. Microbiol. 11: 20.
Vishwakarma R.K. and Brodolin K. (2020) The subunit-remodeling factors: an emerging paradigms of transcription regulation. Front. Immunol. 11: 1798.
Johansen M.D. and Kremer L. (2020) CFTR depletion confers hypersusceptibility to Mycobacterium fortuitum in a zebrafish model. Front. Cell. Infect. Microbiol. 10: 357.
Pradel B., Robert-Hebmann V., and Espert L. (2020) Regulation of innate response by autophagy: a goldmine for viruses. Front. Microbiol. 578038: 1798.
Eldin P., Péron S., Galashevskaya A., Denis-Lagache N., Cogné M., Slupphaug G., and Briant L.* (2020) Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. J. Transl. Med. 18(1):310.
Matsuoka M. and Mesnard J.-M. (2020) HTLV-1 bZIP factor: the key viral gene for pathogenesis. Retrovirology 17(1): 2.
Maillet S., Fernandez J., Decourcelle M., El Koulali K., Blanchet F.P., Arhel N.J., Maarifi G., and Nisole S. (2020) Daxx inhibits HIV-1 reverse transcription and uncoating in a SUMO-dependent manner. Viruses 12(6): 636.
Eid J., Mougel M., and Socol M. (2020) Advances in continuous microfluidics-based technologies for the study of HIV infection. Viruses 12(9): E982.
Burette M. and Bonazzi M. (2020) From neglected to dissected: how technological advances are leading the way to the study of Coxiella burnetiid pathogenesis. Cell Microbiol. 22(4): e13180.
Wong J.E.M and Blaise M. (2020) Report of false positives when using zymography to assess peptidoglycan hydrolytic activity of an endopeptidase with multiple LySM domains. Biochimie 177: 25-29.
Bozsoki Z., Gysel K., Hansen S.B., Lironi D., Krönauer C., Feng F., de Jong N., Vinther M., Kamble M., Thygesen M.B., Engholm E., Kofoed C., Fort S., Sullivan J.T., Ronson C.W., Jensen K.J., Blaise M., Oldroyd G., Stougaard J., Andersen K.R., Radutoiu S. (2020) Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science 369(6504): 663-670.

2019

Maarifi G., Smith N., Maillet S., Moncorgé O., Chamontin C., Edouard J., Sohm F., Blanchet F.P., Herbeuval J.P., Lutfalla G., Levraud J.P., Arhel N.J., and Nisole S. (2019) TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Sci. Adv. 5(11): eaax3511.
Fernandez J., Machado A.K., Lyonnais S., Chamontin C., Gärtner K., Léger T., Henriquet C., Garcia C., Portilho D.M., Pugnière M., Chaloin L., Muriaux D., Yamauchi, Y., Blaise M., Nisole S., and Arhel N.J. (2019) Nat. Microbiol. 4:1840-1850.
Favard C., Chojnacki J., Merida P., Yandrapalli N., Mak J., Eggeling C.*, Muriaux D.* (2019) Sci. Adv. 5(10): eaaw8651 *Co-corresponding authors.
Ayala-Nunez N.V., Follain G., Delalande F., Hirschler A., Partiot E., Hale G., Bollweg B., Roels J., Chazal M., Bakoa F., Carocci M, Bourdoulous S., Faklaris O., Zaki S., Eckly A., Uring-Lambert B., Doussau F., Cianferani S., Carapito C., Jacobs F., Jouvenet N., Goetz J.G., and Gaudin R. (2019) Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. Nat. Commun. 10(1): 4430.
Hallez C., Li X., Suspène R., Thiers V., Bouzidi M.S. Dorobantu C., Lucansky V., Gaudin R.*, and Vartanian J.P.* (2019) Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus. Nat. Microbiol. 4:1196-1207. *Co-corresponding authors.
Bernut A., Dupont C., Ogryzko N.V., Neyret A., Herrmann J.L., Floto R.A., Renshaw S.A., and Kremer L. (2019) CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defenses. Cell Rep. 26: 1828-1840.
Socol M., Wang R., Jost D., Carrivain P., Vaillant C., Le Cam E., Dahirel V., Normand C., Bystricky K., Victor J.M., Gadal O., and Bancaud A. (2019) Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes. Nucleic Acids Res. 47: 6195-6207.
Deffieu M.S. and Gaudin R. (2019) Imaging the Hepatitis B Virus: Broadcasting live. Trends Microbiol. 27: 810-813.
Maarifi G., Czubala M.A., Lagisquet J., Ivory M.O., Fuchs K., Papin L., Birchall G.C., Nisole S., Piguet V., and Blanchet F.P. (2019) Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cell. Mol. Immunol.
Ouahrani-Bettache S., Jiménez de Bagüés M.P., De la Garza J., Freddi L., Bueso J.P., Lyonnais S. , Al Dahouk S., De Biase D. Köhler S., and Occhialini A. (2019) Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis. Virulence 10: 868-878.
Matkovic R., Bernard E., Fontanel S., Eldin P., Chazal N., Hassan Hersi D., Merits A., Péloponèse J.-M.*, and Briant L.* (2019) The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation. J. Virol. 93:e01764-18. *Co-corresponding authors.
Ung K.L., Alsarraf H.M.A.B., Olieric V., Kremer L.*, and Blaise M.* (2019) Crystal structure of the aminoglycosides N-acetyltransferase Eis2 from Mycobacterium abscessus. FEBS J. 286: 4342-4355. *Co-corresponding authors.
López-Sánchez U., Nicolas G., Richard A.C., Maltête D., Charif M., Ayrignac X., Goizet C., Touhami J., Labesse G., Battini J.-L.*, and Sitbon M.* (2019) Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification. Sci. Rep. 9(1):6776. *Co-corresponding authors.
Dupont C., Chen Y., Xu Z., Roquet-Banères F., Blaise M., Witt A.K., Dubar F., Biot C., Guérardel Y., Maurer F.P., Chng S.S., and Kremer (2019) A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3. J. Biol. Chem. 294:17512-17523.
Guillon R., Rahimova R., Preeti, Egron D., Rouanet S., Dumontet C., Aghajari N., Jordheim L.P., Chaloin L.*, and Peyrottes S.* (2019) Lead optimization and biological evaluation of fragment-based cN-II inhibitors. Eur. J. Med. Chem. 168: 28-44. *Co-corresponding authors.
Bakhache W., Neyret A., McKellar J., Clop C., Bernard E., Weger-Lucarelli J., and Briant L. (2019) Fatty acid synthase and stearoyl-CoA desaturase-1 are conserved druggable cofactors of Old World Alphavirus genome replication. Antivir. Res. 172: 104642.
Neyret A., Gay B., Cransac A., Briant L., Coric P., Turcaud S., Laugâa P., Bouaziz S., and Chazal N. (2019) Insight into the mechanism of action of EP-39, a bevirimat derivative that inhibits HIV-1 maturation. Antivir. Res. 164: 162-175.
Gutiérrez A.V., Richard M., Roquet-Baneres F., Viljoen A., and Kremer L. (2019) The TetR-family transcription factor MAB_2299c regulates the expression of two distinct MmpS-MmpL efflux pumps involved in cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus. Antimicrob. Agents Chemother. 63: e01000-19.
Viljoen A., Raynaud C., Johansen M. D., Roquet-Baneres F., Hermann J.L., Daher W., and Kremer L. (2019) Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages. Antimicrob. Agents Chemother. 63: e00705-19.
Richard M., Gutiérrez A.V., Viljoen A., Rodriguez-Rincon D., Roquet-Baneres F., Blaise M., Everall I., Parhill J., Floto R.A., and Kremer L. (2019) Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus. Antimicrob. Agents Chemother. 63: e01316-18.
Inamdar K., Floderer C., Favard C.*, and Muriaux D.* (2019) Monitoring HIV-1 assembly in living cells: insights from dynamic and single molecule microscopy. Viruses 11: 72. *Co-corresponding authors.
Nisole S., Fernandez J., Maarifi G., and Arhel N. (2019) SUMO regulates the capacity of TRIM5α to inhibit HIV-1. Med. Sci. (Paris) 35: 106-109.

2018

Doyle T., Moncorgé O., Bonaventure B., Pollpeter D., Lussignol M., Tauziet M., Apolonia L., Catanese M.T., Goujon C.*, and Malim M.H.* (2018) The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry. Nat. Microbiol. 3: 1369-1376. *Co-corresponding authors.
Chopard C., Tong P.B.V., Tóth P., Schatz M., Yezid H., Debaisieux S., Mettling C., Gross A., Pugière M., Tu A., Strub J.-M. Mesnard J.-M., Vitale N., and Beaumelle B. (2018) Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nat. Commun. 9(1): 2251.
Maarifi G., Fernandez J., Portilho D.M., Boulay A., Dutrieux J., Oddos S., Butler-Browne G., Nisole S., and Arhel N.J. (2018) RanBP2 regulates the anti-retroviral activity of TRIM5a by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun. Biol. 1: 193.
Vishwakarma R.K., Cao A.M., Morichaud Z., Perumal A.S., Margeat E., and Brodolin K. (2018) Single-molecule analysis reveals the mechanism of transcription activation in M. tuberculosis. Sci. Adv. 4(5): eaao5498.
Martinez E., Siadous F.A., and Bonazzi M. (2018) Tiny architects: biogenesis of intracellular replicative niches by bacterial pathogens. FEMS Microbiol. Rev. 42(4): 425-447.
Sudalaiyadum Perumal A., Vishwakarma R.K., Hu Y., Morichaud Z., and Brodolin K. (2018) RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase. Nucleic Acids Res. 46(19): 10106-10118.
Coulter M.E., Dorobantu C.M., Lodewijk G.A., Delalande F., Cianferani S., Ganesh V.S., Smith R.S., Lim E.T., Xu C.S., Pang S., Wong E.T., Lidov H.G.W., Calicchio M.L., Yang E., Gonzalez D.M., Schlaeger T.M., Mochida G.H., Hess H., Lee W.A., Lehtinen M.K., Kirchhausen T., Haussler D., Jacobs F.M.J., Gaudin R.*, and Walsh C.A.* (2018) The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles. Cell. Rep. 24(4): 973-986. *Co-corresponding authors.
Dicks M.D.J., Betancor G., Jimenez-Guardeno J.M., Pessel-Vivares L., Apolonia L., Goujon C., and Malim M.H. (2018) Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction. Plos. Pathog. 14(11): e1007408.
Mart Floderer C., Masson J.B., Boilley E., Georgeault S., Merida P., El Beheiry M., Dahan M., Roingeard P., Sibarita J.B., Favard C., and Muriaux D. (2018) Single molecule localisation microscopy reveals how HIV-1 Gag proteins sense membrane virus assembly sites in living host CD4 T cells. Sci. Rep. 8: 17426.
Rahimova R., Fontanel S., Lionne C., Jordheim L.P., Peyrottes S., and Chaloin L. (2018 ) Identification of allosteric inhibitors of the ecto-5’-nucleotidase (CD73) targeting the dimer interface. Plos Comput. Biol. 14(1): e1005943.
Schatz M., Tong PBV., and Beaumelle B. (2018) Unconventional secretion of viral proteins. Semin. Cell. Dev. Biol. 83: 8-11.
Gutiérrez A.V., Viljoen A., Ghigo E., Herrmann J.L., and Kremer L. (2018) Glycopeptidolipids, a double-edged sword of the Mycobacterium abscessus complex. Front. Microbiol. 9: 1145.
Gazon H., Barbeau B., Mesnard J.-M., and Peloponese J.-M. (2018) Hijacking of the AP-1 signaling pathway during development of ATL. Front. Microbiol. 8: 2686.
Viljoen A., Gutiérrez A.V., Dupont C., Ghigo E., and Kremer L. (2018) A simple and rapid gene disruption strategy in Mycobacterium abscessus: On the design and application of glycopeptidolipid mutants. Front. Cell. Infect. Microbiol. 8: 69.
Viljoen A., Richard M., Nguyen PC., Fourquet P., Camoin L., Paudal R.R., Gnawali G.R., Spilling C.D., Cavalier J.F., Canaan S., Blaise M., and Kremer L. (2018) Cyclipostins and cyclophostin analog inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo. J. Biol. Chem. 293(8): 2755-2769.

2017

Terol M., Gazon H., Lemasson I., Duc Dodon M., Barbeau B., Césaire R., Mesnard J.-M., and Peloponese J.-M. (2017) HBZ-mediated shift of JunD from growth suppressor to tumor promoter by inhibition of ribosomal protein S25 expression. Leukemia 31(10): 2235-2243.
Smith N., Pietrancosta N., Davidson S., Dutrieux J., Chauveau L., Cutolo P., Dy M., Scott-Algara D., Manoury B., Zirafi O., McCort-Tranchepain I., Durroux T., Bachelerie F., Schwartz O., Münch J., Wack A., Nisole S., and Herbeuval J.P. (2017) Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat. Commun. 8: 14253.
Abdou E., Jiménez de Bagüés M.P., Martínez-Abadía I., Ouahrani-Bettache S., Pantesco V., Occhialini A., Al Dahouk S., Köhler S., and Jubier-Maurin V. (2017) RegA plays a key role in oxygen-dependent establishment of persistence and in Isocitrate Lyase activity, a critical determinant of in vivo Brucella suis pathogenicity. Front. Cell. Infect. Microbiol. 7: 186.
Häuslein I., Cantet F., Reschke S., Chen F., Bonazzi M., and Eisenreich W. (2017) Multiple substrates usage of Coxiella burnetii to fedd a bipartite metabolic network. Front. Cell. Infect. Microbiol. 7: 285.
Viljoen A, Herrmann J.L., Onajole O.K., Stec J., Kozikowski A.P., and Kremer L. (2017) Controlling extra- and intramacrophagic Mycobacterium abscessus by targeting mycolic acid transport. Front. Cell. Infect. Microbiol. 7: 388.
Kozikowski A.P., Onajole O.K., Stec J., Dupont C., Viljoen A., Richard M., Chaira T., Lun S., Bishai W., Raj V.S., Ordway D.,and Kremer L. (2017) Targeting mycolic acid transport by Indole-2-carboxamides for the treatment of Mycobacterium abscessus infections. J. Med. Chem. 60(13): 5876-5888.
Viljoen A., Dubois V., Girard-Misguich F., Blaise M., Herrmann J.L., Kremer L. (2017) The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments. Mol. Microbiol. 104: 889-904.
Van Wyk N., Navarro D., Blaise M., Berrin J.G., Henrissat B., Drancourt M., Kremer L. (2017) Characterization of a mycobacterial cellulose and its impact on biofilm- and drug-induced cellulose production. Glycobiology 27: 392-99.
Halloum S., Viljoen A., Khanna V., Craig D., Bouchier C., Brosch R., Coxon G., and Kremer L. (2017) Resistance to Thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384. Antimicrob. Agents Chemother. 61: 2509-16.
Vergne I., Lafont F., Espert L., Esclatine A., and Biard-Piechaczyk M. (2017) Autophagy, ATG proteins, and infectious diseases. Med. Sci. (Paris) 33: 312-18.

2016

Cassan E., Arigon Chifolleau A.-M., Mesnard J.-M., Gross A.*, and Gascuel O.* (2016) Concomitant emergence of the “AntiSenseProtein” gene of HIV-1 and of the pandemic. Proc. Natl. Acad. Sci. USA. 113: 11537-42. *co-last authors.
Halloum S., Carrère-Kremer S., M. Blaise A., Viljoen A., Bernut A., Le Moigne V., Vilchèze C., Guérardel Y., Lutfalla G., Herrmann J.L., Jacobs W.R., Jr., and Kremer L. (2016) Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proc. Natl. Acad. Sci. USA. 113: 4228-37.
Martinez E., Allombert J., Cantet F., Lakhani A., Yandrapalli N., Neyret A., Norville I.H., Favard C., Muriaux D., and Bonazzi M. (2016) Coxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole development. Proc. Natl. Acad. Sci. USA.113: 3260-69.
Ferrer M., Clerte C., Chamontin C., Basyuk E., Laine S., Hottin J., Bertrand E., Margeat E., and Mougel, M. (2016) Imaging HIV-1 RNA dimerization in cells by multicolour super-resolution and fluctuation microscopies. Nucleic Acids Res, 44: 7922-34.
Bernut A, Nguyen-Chi M, Halloum I, Herrmann JL, Lutfalla G, and Kremer L. (2016) Mycobacterium abscessus-induced granuloma formation is strictly dependent on TNF signaling a,d neutrophil trafficking. PLoS Pathog. 12: e1005986.
Picas L., Gaits-Iacovoni F., and Goud B. (2016) The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction. F1000 Faculty Reviews-422.
Duchi D., Bauer D.L., Fernandez L., Evans G., Robb N., Hwang L.C., Gryte K., Tomescu A., Zawadzki P., Morichaud Z., Brodolin K., and Kapanidis A.N. (2016) RNA polymerase pausing during initial transcription. Mol. Cell. 63: 939-50.
Portilho D.M., Fernandez J., Ringeard M., Machado A.K., Boulay A., Mayer M., Müller-Trutwin M., Beignon A.S., Kirchhoff F., Nisole S., and Arhel N.J. (2016) Endogenous TRIM5α function is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Rep. 14, 355-69.
Dupont C., Viljoen A., Dubar F., Blaise M., Bernut A., Pawlik A., Bouchier C., Brosch R., Guérardel Y., Lelièvre J., Ballell L., Herrmann J.L., Biot C., and Kremer L. (2016) A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus. Mol. Microbiol. 101: 515-29.
Singh V., Berry L., Bernut A., Singh S., Carrère-Kremer S., Viljoen A., Alibaud L., Majlessi L., Brosch R., Chaturvedi V., Geurtsen J., Drancourt M., and Kremer L. (2016) A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts. Cell. Microbiol. Mol. Microbiol. 101: 1489-507.
Bernut A., Viljoen A., Dupont C., Sapriel G., Blaise M., Bouchier C., Brosch R., de Chastellier C., Herrmann J.L., and Kremer L. (2016) Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members. Mol. Microbiol. 99: 866-83.
Yandrapalli N., Lubart Q., Tanwar H.S., Picart C., Mak J., Muriaux D.,and Favard C. (2016) Self assembly of HIV-1 Gag protein on lipid membranes generates PI(4,5)P₂/Cholesterol nanoclusters. Sci. Rep. 6: 39332.
Racine P.J., Chamontin C., de Rocquigny H., Bernacchi S., Paillart J.C., and Mougel M. (2016) Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly. Sci. Rep. 6: 27536.
Morichaud Z., Chaloin L., and Brodolin K. (2016) Regions 1.2 and 3.2 of the RNA polymerase sigma subunit promote DNA melting and attenuate action of the antibiotic Lipiarmycin. J. Mol. Biol. 428: 463-76.
Kerviel A. , Dash S., Moncorgé O., Panthu B., Prchal J., Favard C., Décimo D., Ohlmann T., Lina B.,, Ottmann M., Roingeard P., and Muriaux D. (2016) Involvement of an Arginine triplet in M1 Matrix protein-membrane interaction and in M1 recruitment into virus-like-particles of the Influenza A(H1N1)pdm09 virus. Plos One 11: e0165421
Mariani-Floderer C., Sibarita J.-B., Favard C., and Muriaux D. (2016) Hunting Down HIV-1 Gag Proteins at the Plasma Membrane of Human T Lymphocytes. AIDS Res Hum Retroviruses 32: 658-59.
Ferrer M., Henriet S., Chamontin C., Lainé S., and Mougel M. (2016) From cells to virus particles: quantitative methods to monitor RNA packaging. Viruses. 8: E239.

2015

Debaisieux S., Lachambre S., Gross A., Mettling C., Besteiro S., Yezid H., Henaff D., Chopard C., Mesnard J.-M., and Beaumelle B. (2015) HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup. Nat. Commun. 6: 6211.
Chamontin C., Rassam P., Ferrer M., Racine P.J., Neyret A., Lainé S., Milhiet P.E, and Mougel M. (2015) HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus. Nucleic Acids Res. 43: 336-47.
Doyle T., Goujon C., and Malim MH. (2015) HIV-1 and interferons: who’s interfering with whom? Nature Reviews Microbiology 13: 403-13.
Legati A., Giovannini D., NicolasG., …, Geschwind D.H., Battini J.-L., and Coppola G. (2015) Mutations in XPR1 causes primary familial brain calcification associated with altered phosphate export. Nat. Genet. 47: 579-81.
Barbeau B. and Mesnard J.-M. (2015) Does chronic infection in retroviruses have a sense? Trends Microbiol. 23: 367-75.
Adjili S., Favier A., Fargier G., Thomas A., Massin J., Monier N., Favard C., Vanbelle S., Bruneau N., Peyriéras C., Andraud D., Muriaux D.*, and Charreyre M.* (2015) Biocompatible Photoresistant Far-Red Emitting Fluorescent Polymer Probes with Near-Infrared Two-Photon Absorption for Living Cell and Zebrafish Embryo Imaging. Biomaterials, 46:70-81. *co-last authors.
Dutrieux J., Maarifi G., Portilho D.M., Arhel N.J., Chelbi-Alix M.K., Nisole S. (2015) PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx. PLoS Pathog. 11: e1005280.
Sagnier S., Daussy C.F., Beaumelle B., Borel S., Robert-Hebmann V., Faure M., Blanchet F.P., Biard-Piechaczyk M. and Espert L. (2015) Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4 T lymphocytes. J. Virol. 89: 615-25.
Thomas A., Mariani-Floderer C., López-Huertas M.R., Gros N., Hamard-Péron E., Favard C., Ohlmann T., Alcamí J., and Muriaux D. (2015) Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells. J. Virol. 89, 8162-81.
Goujon C., Greenbury R., Papaioaanou S., Doyle T., and Malim M.H. (2015) A triple arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2. J. Virol. 89, 4676-80.
Pessel-Vivares L., Houzet L., Laine, S., and Mougel M. (2015) Insights into the nuclear export of murine leukemia virus intron-containing RNA. RNA Biol. 12: 942-9.
Borel S., Robert-Hebmann V., Alfaisal J., Jain A., Faure M., Espert L., Chaloin L., Paillart J. C., Johansen T., and Biard-Piechaczyk M. (2015) HIV-1 Vif interacts with LC3 and inhibits autophagy. AIDS. 29: 275–286.
Bernard E, Hamel R., Neyret A., Ekchariyawat P., Molès J.P., Simmons G., Chazal N., Desprès P., Missé D., and Briant L. (2015) Human keratinocytes restrict Chikungunya virus replication at a post-fusion step. Virology 476:1-10.
Damiano M.A., Bastianelli D., Al Dahouk S., Köhler S., Cloeckaert A., De Biase D., and Occhialini A. (2015) Glutamate decarboxylase-dependent acid resistance in Brucella spp.: Distribution and contribution to fitness under extreme acid conditions. Appl. Environ. Microbiol. 81: 578-86.
Saad J.S. and Muriaux D. (2015) Editorial: Role of lipids in virus assembly. Front Microbiol. 6: 410.
Espert L., Beaumelle B., and Vergne I. (2015) Autophagy in Mycobacterium tuberculosis and HIV infections. Front Cell Infect Microbiol. 5: 49.
Mesnard J.-M., Barbeau B., Césaire R., and Péloponèse J.-M. (2015) Roles of HTLV-1 basic Zip Factor (HBZ) in viral chronicity and leukemic transformation. Potential new therapeutic approaches to prevent and treat HTLV-1-related diseases. Viruses 7: 6490-6505.