Blaise Mickael

Fonctions

Directeur de Recherche 2- CNRS

HDR

Equipe

Enzymes bactériennes et résistance aux antibiotiques

Contact

email : mickael.blaise(at)irim.cnrs.fr

Tél : 04 34 35 94 68

ORCID: https://orcid.org/0000-0002-7860-3464

Publications (5 dernières années )

Self-control of vitamin K₂ production captured in the crystal.

Blaise M, Kremer L.

J Biol Chem. 2020 Mar 20;295(12):3771-3772. doi: 10.1074/jbc.H120.013113.

Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors.

de Ruyck J, Dupont C, Lamy E, Le Moigne V, Biot C, Guérardel Y, Herrmann JL, Blaise M, Grassin-Delyle S, Kremer L, Dubar F.

ChemistryOpen. 2020 Mar 20;9(3):351-365. doi: 10.1002/open.202000042.

Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus.

Raynaud C, Daher W, Johansen MD, Roquet-Banères F, Blaise M, Onajole OK, Kozikowski AP, Herrmann JL, Dziadek J, Gobis K, Kremer L.

ACS Infect Dis. 2020 Jan 7. doi: 10.1021/acsinfecdis.9b00389.

1H-benzo[d]imidazole derivatives affect MmpL3 in Mycobacterium tuberculosis.

Korycka-Machała M, Viljoen A, Pawełczyk J, Borówka P, Dziadek B, Gobis K, Brzostek A, Kawka M, Blaise M, Strapagiel D, Kremer L, Dziadek J.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00441-19. doi: 10.1128/AAC.00441-19.

Crystal structure of the aminoglycosides N-acetyltransferase Eis2 from Mycobacterium abscessus.

Ung KL, Alsarraf HMAB, Olieric V, Kremer L, Blaise M. FEBS J. 2019 Jun 29. doi: 10.1111/febs.14975.

A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation.

Wong JEMM, Nadzieja M, Madsen LH, Bücherl CA, Dam S, Sandal NN, Couto D, Derbyshire P, Uldum-Berentsen M, Schroeder S, Schwämmle V, Nogueira FCS, Asmussen MH, Thirup S, Radutoiu S,

Blaise M, Andersen KR, Menke FLH, Zipfel C, Stougaard J.

Proc Natl Acad Sci U S A. 2019 Jun 25. pii: 201815425. doi: 10.1073/pnas.1815425116.

Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen A, Rodriguez-Rincon D, Roquet-Baneres F, Blaise M, Everall I, Parkhill J, Floto RA, Kremer L.

Antimicrob Agents Chemother. 2018 Oct 15. pii: AAC.01316-18. doi: 10.1128/AAC.01316-18.

MmpL8_MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family.

Dubois V, Viljoen A, Laencina L, Le Moigne V, Bernut A, Dubar F, Blaise M, Gaillard JL, Guérardel Y, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Oct 9. pii: 201812984. doi: 10.1073/pnas.1812984115

E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form.

Johansen JS, Kavaliauskas D, Pfeil SH, Blaise M, Cooperman BS, Goldman YE, Thirup SS, Knudsen CR.

Nucleic Acids Res. 2018 Aug 11. doi: 10.1093/nar/gky697

Epidermal LysM receptor ensures robust symbiotic signalling in Lotus japonicus.

Murakami E, Cheng J, Gysel K, Bozsoki Z, Kawaharada Y, Hjuler CT, Sørensen KK, Tao K, Kelly S, Venice F, Genre A, Thygesen MB, Jong N, Vinther M, Jensen DB, Jensen KJ, Blaise M, Madsen LH, Andersen KR, Stougaard J, Radutoiu S.

Elife. 2018 Jun 29;7. pii: e33506. doi: 10.7554/eLife.33506.

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen AJ, Ghigo E, Blaise M, Kremer L.

Front Microbiol. 2018 Apr 5;9:649. doi: 10.3389/fmicb.2018.00649. eCollection 2018.

Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis β-ketoacyl-acyl carrier protein reductase MabA.

Küssau T, Flipo M, Van Wyk N, Viljoen A, Olieric V, Kremer L, Blaise M.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):383-393. doi: 10.1107/S2059798318002917.

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L.

J Biol Chem. 2018 Feb 23;293(8):2755-2769. doi: 10.1074/jbc.RA117.000760.

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering.

Midtgaard SR, Darwish TA, Pedersen MC, Huda P, Larsen AH, Jensen GV, Kynde SAR, Skar-Gislinge N, Nielsen AJZ, Olesen C, Blaise M, Dorosz JJ, Thorsen TS, Venskutonytė R, Krintel C, Møller JV, Frielinghaus H, Gilbert EP, Martel A, Kastrup JS, Jensen PE, Nissen P, Arleth L.

FEBS J. 2018 Jan;285(2):357-371. doi: 10.1111/febs.14345.

Receptor-mediated chitin perception in legume roots is functionally separable from Nod factor perception.

Bozsoki Z, Cheng J, Feng F, Gysel K, Vinther M, Andersen KR, Oldroyd G, Blaise M, Radutoiu S, Stougaard J.

Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201706795. doi: 10.1073/pnas.1706795114.

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.

Viljoen A, Dubois V, Girard-Misguich F, Blaise M, Herrmann JL, Kremer L.

Mol Microbiol. 2017 Jun;104(6):889-904. doi: 10.1111/mmi.13675. Epub 2017 Apr 18. Review.

Characterization of a mycobacterial cellulase and its impact on biofilm- and drug-induced cellulose production.

Van Wyk N, Navarro D, Blaise M, Berrin JG, Henrissat B, Drancourt M, Kremer L.

Glycobiology. 2017 May 1;27(5):392-399. doi: 10.1093/glycob/cwx014.

Binding of NADP ⁺ triggers an open-to-closed transition in a mycobacterial FabG β-ketoacyl-ACP reductase.

Blaise M*, Van Wyk N, Banères-Roquet F, Guérardel Y, Kremer L.*

Biochem J. 2017 Mar 7;474(6):907-921. doi: 10.1042/BCJ20161052.

MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus.

Viljoen A, Blaise M, de Chastellier C, Kremer L.

Mol Microbiol. 2016 Nov;102(4):611-627. doi: 10.1111/mmi.13482.

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113.

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L.

Mol Microbiol. 2016 Aug;101(3):515-29. doi: 10.1111/mmi.13406.

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L.

Mol Microbiol. 2016 Mar;99(5):866-83. doi: 10.1111/mmi.13283.

Receptor-mediated exopolysaccharide perception controls bacterial infection.

Kawaharada Y, Kelly S, Nielsen MW, Hjuler CT, Gysel K, Muszyński A, Carlson RW, Thygesen MB, Sandal N, Asmussen MH, Vinther M, Andersen SU, Krusell L, Thirup S, Jensen KJ, Ronson CW, Blaise M, Radutoiu S, Stougaard J.

Nature. 2015 Jul 16;523(7560):308-12. doi: 10.1038/nature14611.

An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.

Wong JE, Midtgaard SR, Gysel K, Thygesen MB, Sørensen KK, Jensen KJ, Stougaard J, Thirup S, Blaise M.*

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):592-605.doi:10.1107/S139900471402793X. *corresponding author

A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis.

Carrère-Kremer S, Blaise M, Singh VK, Alibaud L, Tuaillon E, Halloum I, van de Weerd R, Guérardel Y, Drancourt M, Takiff H, Geurtsen J, Kremer L.

Mol Microbiol. 2015 Jun;96(5):1085-102. doi: 10.1111/mmi.12992.

Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis.

Nemie-Feyissa D, Heidari B, Blaise M, Lillo C.

Phytochemistry. 2015 Mar;111:21-6. doi: 10.1016/j.phytochem.2015.01.004.

Critical role of zinc ion on E. coli glutamyl-queuosine-tRNA(Asp) synthetase (Glu-Q-RS) structure and function.

Ray S, Banerjee V, Blaise M, Banerjee B, Das KP, Kern D, Banerjee R.

Protein J. 2014 Apr;33(2):143-9. doi: 10.1007/s10930-014-9546-1.

Lipochitin oligosaccharides immobilized through oximes in glycan microarrays bind LysM proteins.

Maolanon NN, Blaise M, Sørensen KK, Thygesen MB, Cló E, Sullivan JT, Ronson CW, Stougaard J, Blixt O, Jensen KJ.

Chembiochem. 2014 Feb 10;15(3):425-34. doi: 10.1002/cbic.201300520. Epub 2014 Jan 16.

Fusion with anticodon binding domain of GluRS is not sufficient to alter the substrate specificity of a chimeric Glu-Q-RS.

Ray S, Blaise M, Roy B, Ghosh S, Kern D, Banerjee R.

Protein J. 2014 Feb;33(1):48-60. doi: 10.1007/s10930-013-9537-7.

Cooperative binding of LysM domains determines the carbohydrate affinity of a bacterial endopeptidase protein.

Wong JE, Alsarraf HM, Kaspersen JD, Pedersen JS, Stougaard J, Thirup S, Blaise M.

FEBS J. 2014 Feb;281(4):1196-208. doi: 10.1111/febs.12698.

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