Fonction
Ingénieur de Recherche, responsable du Plateau Technique Virus Respiratoires, PhD, HDR
Equipe
Interféron et restriction antivirale – Caroline Goujon
Contact
email :
Tél : 04 34 35 94 33
Publications
* : co-corresponding auteur
McKellar J, García de Gracia F, Aubé C, Chaves Valadão AL, Tauziet M, Arnaud-Arnould M, Rebendenne A, Neyret A, Labaronne E, Ricci E, Delaval B, Gaudin R, Naffakh N, Gallois-Montbrun S, Moncorgé O*, Goujon C*. Human MX1 induces the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs bioRxiv DOI 10.1101/2024.02.22.581565, February 22, 2024.
McKellar J, Moncorgé O*, Goujon C*. MX1 proteins and influenza A virus under the microscope. Virologie (Montrouge). 2023 Feb 1;27(1):18-21. doi: 10.1684/vir.2023.989.
McKellar J, Arnaud-Arnould M, Chaloin L, Tauziet M, Arpin-André C, Pourcelot O, Blaise M, Moncorgé O*, Goujon C*. An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses. J Biol Chem. 2023 Jan;299(1):102747. doi: 10.1016/j.jbc.2022.102747. Epub 2022 Nov 25.
Bonaventure B, Rebendenne A, Chaves Valadão AL, Arnaud-Arnould M, Gracias S, Garcia de Gracia F, McKellar J, Labaronne E, Tauziet M, Vivet-Boudou V, Bernard E, Briant L, Gros N, Djilli W, Courgnaud V, Parrinello H, Rialle S, Blaise M, Lacroix L, Lavigne M, Paillart JC, Ricci EP, Schulz R, Jouvenet N, Moncorgé O, Goujon C. The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses. EMBO Rep. 2022 Nov 7;23(11):e54061. doi: 10.15252/embr.202154061. Epub 2022 Sep 26.
Rebendenne A, Roy P, Bonaventure B, Chaves Valadão AL, Desmarets L, Arnaud-Arnould M, Rouillé Y, Tauziet M, Giovannini D, Touhami J, Lee Y, DeWeirdt P, Hegde M, Urbach S, Koulali KE, de Gracia FG, McKellar J, Dubuisson J, Wencker M, Belouzard S, Moncorgé O, Doench JG, Goujon C. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nature Genet. 2022 Aug;54(8):1090-1102. doi: 10.1038/s41588-022-01110-2. Epub 2022 Jul 25.
Gheeraert A, Vuillon L, Chaloin L, Moncorgé O, Very T, Perez S, Leroux V, Chauvot de Beauchêne I, Mias-Lucquin D, Devignes MD, Rivalta I, Maigret B. Singular Interface Dynamics of the SARS-CoV-2 Delta Variant Explained with Contact Perturbation Analysis. J Chem Inf Model. 2022 Jun 27;62(12):3107-3122. doi: 10.1021/acs.jcim.2c00350. Epub 2022 Jun 6.
Arnaud-Arnould M, Tauziet M, Moncorgé O, Goujon C, Blaise M. Crystal structure of the TLDc domain of human NCOA7-AS. Acta Crystallogr F Struct Biol Commun. 2021 Aug 1
Maarifi G, Lagisquet J, Hertel Q, Bonaventure B, Chamontin C, Fuchs K, Moncorgé O, Tauziet M, Mombled M, Papin L, Molès JP, Bodet C, Lévèque N, Gross A, Arhel N, Nisole S, Van de Perre P, Goujon C, Blanchet FP. Alarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells. EMBO J. 2021 Jun 14
McKellar J, Rebendenne A, Wencker M, Moncorgé O*, Goujon C*. Mammalian and Avian Host Cell Influenza A Restriction Factors. Viruses. 2021 Mar 22;13(3):522.
Pila-Castellanos I, Molino D, McKellar J, Lines L, Da Graca J, Tauziet M, Chanteloup L, Mikaelian I, Meyniel-Schicklin L, Codogno P, Vonderscher J, Delevoye C, Moncorgé O, Meldrum E, Goujon C, Morel E, de Chassey B. Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.
PLoS Pathog. 2021 Feb 17;17(2)
Rebendenne A, Valadão ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planès R, Nisole S, Arnaud-Arnould M, Moncorgé O*, Goujon C*. SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells. J Virol. 2021 Jan 29:JVI.02415-20.
Maarifi G, Smith N, Maillet S, Moncorgé O, Chamontin C, Edouard J, Sohm F, Blanchet FP, Herbeuval JP, Lutfalla G, Levraud JP, Arhel NJ, Nisole S. TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Science Advances 2019 Nov 20 ;5(11).
Artarini A, Meyer M, Shin YJ, Huber K, Hilz N, Bracher F, Eros D, Orfi L, Keri G, Goedert S, Neuenschwander M, von Kries J, Domovich-Eisenberg Y, Dekel N, Szabadkai I, Lebendiker M, Horváth Z, Danieli T, Livnah O, Moncorgé O, Frise R, Barclay W, Meyer TF, Karlas A. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Research. 2019 Aug;168:187-196.
Doyle T, Moncorgé O, Bonaventure B, Pollpeter D, Lussignol M, Tauziet M, Apolonia L, Catanese MT, Goujon C, Malim MH. The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry. Nature Microbiology. 2018 Dec;3(12):1369-1376.
Kerviel A, Dash S, Moncorgé O, Panthu B, Prchal J, Décimo D, Ohlmann T, Lina B, Favard C, Decroly E, Ottmann M, Roingeard P, Muriaux D. Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus. PLoS One. 2016 Nov 4;11(11).
Long, J.S., Giotis, E.S., Moncorgé, O., Frise, R., Mistry, B., James, J., Morisson, M., Iqbal, M., Vignal, A., Skinner, M.A., and Barclay, W.S. (2016). Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature 529(7584):101-4.
Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Barclay, W.S., and Malim, M.H. (2014). Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor. Journal of Virology 15;88(16):9017-26.
Cauldwell, A.V., Long, J.S., Moncorgé, O., and Barclay, W.S. (2014). Viral determinants of influenza A virus host range (review). Journal of General Virology. 95(Pt 6):1193-210.
Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Ward, C.C., Schaller, T., Hué, S., Barclay, W.S., Schulz, R., and Malim, M.H. (2013). Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature. Oct 24;502(7472):559-62.
Long, J.S., Howard, W.A., Núñez, A., Moncorgé, O., Lycett, S., Banks, J., and Barclay, W.S. (2013). The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage. Journal of Virology 87(18):9983-96.
Cauldwell, A.V., Moncorgé, O., and Barclay, W.S. (2013). Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells. Journal of Virology 87(2):1278-84.
Moncorgé, O., Long, J.S., Cauldwell, A.V., Zhou, H., Lycett, S.J., and Barclay, W.S. (2013). Investigation of influenza virus polymerase activity in pig cells. Journal of Virology 87(1):384-94.
Moncorgé, O., Mura, M., and Barclay, W.S. (2010). Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. Journal of Virology 84(19):9978-86.
Bickle, M., Dusserre, E., Moncorgé, O., Bottin, H., and Colas, P. (2006). Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures. Nature Protocols 1(3):1066-91.