Les séminaires de recherche à l'IRIM

Les séminaires à l’IRIM ont lieu tous les vendredis à 11h00 dans la salle « Marcel Dorée ». Il y a une alternance entre séminaires internes faits par les équipes et les séminaires externes sur invitation (voir liste ci-dessous).

Début 2019, l’IRIM a également lancé une nouvelle série séminaire 'career outside academia seminars’ visant à présenter aux doctorants et postdoctorants du campus les parcours professionnels possibles en dehors de la recherche académique, après un doctorat et post-doctorat. Ces séminaires ont lieu dans un contexte informal et détendu, laissant libre cours aux questions et discussions. Plus d'information ici.

Futurs séminaires :

  • Pr Alessia Zamborlini (Paris Saclay University). "SUMOylation of Lysine 595 cooperates with phosphorylation of Threonine 592 to regulate SAMHD1 antiviral activity" POSTPONED DUE TO COVID19 PANDEMIC

Summary of the talk: SAMHD1 is a cellular triphosphohydrolase that inhibits the replication of HIV-1 in non-cycling immune cells by reducing the concentration of dNTP below a threshold required for efficient reverse transcription of the viral genome. Phosphorylation of residue T592 suppresses the antiviral activity of SAMHD1 in cycling cells. However, phosphomimetic mutants efficiently deplete the cellular dNTP pools, indicating that additional functions and/or post-translational modifications play a role in the regulation of SAMHD1 restriction activity.

A. Zamborlini's team found that SAMHD1 is SUMOylated on residue K595, a modification that relies on the integrity of a SUMO-interacting motif. Furthermore, their data provide compelling evidence that, in non-cycling cells where most of the protein harbors an unphosphorylated T592 residue, SUMOylation of K595 defines the fraction of restriction competent SAMHD1.

Minibio du Pr. Alessandra Zamborlini : A. Zamborlini a obtenu un diplôme M2 en Chimie et Technologies Pharmaceutiques (Faculté de Pharmacie) puis un PhD en Virologie (Faculté de Médecine) à l'Université de Padoue (Italie). Au cours de sa formation doctorale, elle a étudié le rôle des composants cellulaires de la machinerie ESCRT dans le bourgeonnement du VIH-1 dans le laboratoire de Heinrich Gottlinger (Harvard Medical School, Boston, USA). Elle a ensuite rejoint le laboratoire d'Ali Saïb en tant que post-doctorante où elle a développé plusieurs projets visant à mieux comprendre la persistance du virus dans les cellules T quiescentes et la régulation de l'étape d'intégration par des modifications post-traductionnelles. En 2010 elle a obtenu un poste de Maître de conférences au Cnam (Conservatoire national des arts et métiers, Paris), puis en 2019 un poste de Professeur de Virologie à l'Université Paris Saclay. Ses projets de recherche visent à déchiffrer les bases moléculaires sous-jacentes à la coordination des multiples activités de SAMHD1 ainsi que la contribution de SUMOylation à la réponse antivirale dans les cellules immunitaires au repos ou post-mitotiques.


  • Dr Christophe Mueller (Strasbourg university). "Host immune evasion by Pseudomonas aeruginosa? A study of the impact of its lectin LecB on the murine immune system." POSTPONED DUE TO COVID19 PANDEMIC

Dr. Christopher Mueller is CNRS director of research at the University of Strasbourg, France, and the CNRS research team Immunology and Immunopathology. He has obtained his PhD in Heidelberg / the University of London on c-fos transcription factors and spent two years as a postdoctoral fellow in UC-Berkeley working on transcriptional regulation in the yeast S. cerevisiae. He became an immunologists at Schering-Plough, Inc., France, and integrated the French national research system CNRS to continue his research on the immunobiology of the myeloid cell lineage in the skin and lymphoid tissue. He now heads a research team in Strasbourg to study the impact of the cellular microenvironment on immune cell differentiation and activation in the context of infection and autoimmunity. He has recently shown that mesenchymal cells instruct lymphatic endothelial cells via TNFSF11 (RANKL) – TNFRSF11a (RANK) to create the niche for sinusoidal macrophage differentiation.

He is a member of the Labex Medalis, former director of the International PhD programme of the University of Strasbourg, and co-founder of the Upper Rhine Immunology group, comprising the Universities of Strasbourg, Freiburg and Basel.


  • Dr. Sarah Gallois-Montbrun (Institut Cochin, Paris"Non-canonical Roles of Argonaute proteins in HIV-1 viral RNA expression" - initialement planifié le 13 Décembre 2019 mais reporté à une date ultérieure

Summary of the talk: During its replication, HIV-1 produces more than 50 different transcripts coding for all the proteins necessary for viral particles assembly. Balanced production of viral isoforms is highly regulated both temporally and spatially. Current research in my group aims at characterizing the role of viral and cellular factors involved in HIV-1 RNA production. In particular, we investigated the role of the miRNA pathway and demonstrated that key proteins of these pathway, Argonaute 1 and Argonaute 2, participate at different levels of viral RNA production independently of the presence of miRNA. In parallel, we recently developed a long-read sequencing assay to quantify production of HIV-1 isoforms and to decipher the cascade of splicing events taking place at early time points after infection. 

Dr Gallois-Montbrun's minibiography: After completing her PhD studies at Pasteur Institute Paris in 2004 on cellular metabolism of anti-HIV-1 drugs, she undertook post-doctoral training with Prof Michael Malim at King’s College London. There she focused on characterizing cellular protein and RNA partners of APOBEC3G and APOBEC3F, two HIV-1 restriction factors. She was recruited as Inserm research scientist at Cochin Institute in 2009.  Since then, her group has aimed at dissecting mechanisms regulating HIV-1 RNA fate and how these impact on viral replication.


Séminaires passés :

  • Prof. Jack Stapleton (Iowa university, USA) "A flavivirus genome-derived noncoding RNA regulates T cell function and restricts virus replication" Friday the 21st of February 11 am

Jack Stapleton's minibio: Jack is a Professor of Internal Medicine, Infectious Diseases and Microbiology at the University of Iowa.  Over the last 3 decades, his laboratory has focused on positive strand RNA viruses (HIV, HCV, GBV-C/HPgv) and how members of the Flaviviridae interact with HIV and immune function.  Most recently, the lab studies how HCV and yellow fever virus genomic RNA is processed into short, noncoding RNAs that regulate T cell function and enhance viral replication.  He also has conducted numerous translational studies on how human pegivirus (GBV-C) prolongs survival in HIV infected people, and characterized mechanisms involved in this beneficial co-infection.

  • Dr. Philippe Benaroch "Host-HIV interplay in human primary myeloid cells" - 22 Novembre 2019

Philippe Benaroch is research director at the CNRS and heads the team “Myeloid cells and immunity” within the Department of Immunology at the Institut Curie in Paris. He will present recent work and unpublished data regarding a recently identified blood dendritic cell subset, its unique relationship with HIV and some of its shared properties with infected macrophages.

Philippe Benaroch is particularly interested by myeloid cells that represent a very ancient form of cellular immunity against pathogens and tumor cells. Myeloid cells are very plastic, endowed with an ever-growing list of functions in innate and adaptive immunity. How myeloid cells crosstalk with HIV and tumor cells and how this interplay is regulated remains to be established at the molecular level and represent the focus of his lab.


  • Dr. Lise Chauveau (Oxford university, UK) "The immune system’s Trojan horse: Using cGAMP-loaded VLPs for vaccination"  - 11 Octobre 2019

Dr Lise Chauveau is interested in how viruses induce an immune response, the type of response induced and how viruses may counteract it. She studied Biology at the Ecole Normal Superieure de Lyon where she obtained a Master degree in 2012. She then moved to the Pasteur Institute in Paris to complete a PhD in the laboratory of Prof Olivier Schwartz in 2016. There, she studied factors influencing the ability of HIV-1 and HIV-2 to infect cells of the immune system, CD4 T cells and dendritic cells. This is where her interest in antiviral immunity and how viruses might modulate it sparked. She is now a postdoctoral researcher with Dr Jan Rehwinkel at the Weatherall Institute of Molecular Medicine, University of Oxford, UK. She currently works on an original vaccination strategy using HIV-derived virus-like particles that incorporate an innate immune messenger (cGAMP) to induce potent and protective immune response against viruses.

  • Prof. Ricardo Soto-Rifo (Universidad de Chile) "The complex life of HIV-1 full-length RNA" - Mardi 1er octobre 2019

Dr. Soto-Rifo has been always interested in the molecular and cellular mechanisms controlling gene expression in Eukaryotes with a special emphasis in RNA viruses as study models. Dr. Soto-Rifo studied biochemistry at Universidad de Santiago de Chile and then moved to France where he obtained a Master in Sciences degree from Université Claude Bernard Lyon-1 in 2006 and then a Ph.D in Life Sciences from Ecole Normale Supérieure de Lyon in 2010. He worked at the Human Virology Department (currently the International Center for Infectiology Research, CIRI) under the supervision of Dr. Théophile Ohlmann on the translational control of the HIV-1 and HIV-2 genomic RNA. During his post-doctoral training at Dr. Ohlmann's lab, Dr. Soto-Rifo worked on the remodeling and localization of the messenger ribonucleoprotein complexes (mRNPs) containing the HIV-1 genomic RNA by analyzing the role of the DEAD-box RNA helicase DDX3 in these processes. In 2013, he moved to Biomedical Sciences Institute at Universidad de Chile Faculty of Medicine to start his own laboratory at the Virology Program. Since then, Dr. Soto-Rifo's reasearch has been mainly focused in understanding the mechanisms involved in RNA metabolism during HIV-1, HIV-2, respiratory syncytial virus and Zika virus replication.

The presentation will be focused on the role of the RNA modification N6-methyladenosine (m6A) and its associated cellular machinery in defining the cytoplasmic destiny of the HIV-1 genomic RNA during the late steps of the viral replication cycle.


  • Dr. Pierre-Olivier Vidalain (CIRI) "Searching for chemical activators of the interferon response : surprises from a chemobiological approach" - 13 Septembre 2019

Pierre-Olivier Vidalain, Directeur de Recherche, CNRS. Après avoir soutenu une thèse en immunologie à l’Ecole Normale Supérieure de Lyon, Pierre-Olivier s’est familiarisé avec les techniques de criblage à haut débit et l’étude des interactions protéine-protéine dans l’équipe de Marc Vidal (Harvard Medical School, Boston). Recruté en 2005 au CNRS, il a travaillé successivement à l’Institut Pasteur puis à l’Université Paris Descartes où il a étudié les interactions entre protéines virales et cellulaires et à mis au point différents systèmes pour l’identification de molécules antivirales ciblant l’hôte. Il s’intéresse plus particulièrement aux effets immunomodulateurs de composés inhibant la voie de biosynthèse des pyrimidines. En janvier 2019, il a rejoint le Centre International de Recherche en Infectiologie à Lyon pour poursuivre ses travaux à l’interface entre immunité innée, métabolisme et approches chémobiologiques.


  •  Dr. Jost Enninga (Institut Pasteur, Paris) "Subversion of infection associated macropinosomes drives the intracellular niche formation of bacterial pathogens" - 5 Juillet 2019

Jost Enninga heads the research unit « Dynamics of host-pathogen interactions » within the Department of Cell Biology and Infection at the Institut Pasteur in Paris. He performed his Ph.D. studies in the Laboratory of Cell Biology at the Rockefeller University, New York, under the supervision of Dr. Guenter Blobel. There, he focused on how viruses subvert host cellular trafficking processes. Afterwards, Jost moved to the Institut Pasteur in Paris in 2004 to study the early events of bacterial host cellular invasion with Dr. Philippe Sansonetti and Dr. Guy Tran Van Nhieu. Between 2008 and 2012, Jost built up his own junior team at the Institut Pasteur, and he heads his current research unit since 2013. His team investigates the intracellular niche formation of different bacterial pathogens, including Shigella and Salmonella.  Main questions are membrane trafficking subversion by the pathogens, and how specific intracellular localizations trigger distinct immune responses. His research unit develops imaging-based technologies that allow the analysis of host-pathogen interaction dynamics with unprecedented spatiotemporal resolution.


  • Dr. F. Perez (Institut Curie, Paris) "Exploring the Secretory Pathway : from Basic to Translational Research" - 28 Juin 2019

Dr. Franck Perez is Research Director at CNRS and Chairman of the "Cell Biology and Cancer" Unit of the Institut Curie in Paris. His group is studying intracellular trafficking with an important focus on the development of new methods and tools for Cell Biology studies. For example, he developed at the Institut Curie the use of automated cellular screening and co-founded a High Content screening platform (BioPhenics, with Dr. J. Camonis). In addition, his group created a novel trafficking assay and have strongly invested on the development of recombinant antibodies for cell biology. Recently, he created a novel antibody library based on a humanized nanobody scaffold and created a therapeutic antibody platform.

Dr. F. Perez is Scientific Director of the cell screening platform Biophenics and of the Therapeutic Antibody platform TAbIP and the head of the "Dynamics of Intracellular Organization' team at the Institut Curie. He authored more than 90 scientific articles, developed free software and filled several patents. He is a co-founder of Start-up in the field of immuno- and cellular-therapies, Honing Biosciences.


  • Dr. Sylvie Lecollinet (Virology department at ANSES/Veterinary school, Maisons-Alfort) “From basic to applied research on zoonotic West Nile and Usutu flaviviruses” - 14 Juin 2019
  • Dr. Niedergang Florence (Institut Cochin - Paris) "Macrophages upon viral infection, emergence of opportunistic diseases" - 9 Mai 2019
  • Dr. Mauffret Olivier (LBPA - ENS Cachan) "Structures-functions relationships of the zinc fingers domains of HIV-1 nuclecocapsid protein" - 15 Février 2019
  • Dr. Manel Nicolas (Institut Curie) - "Activation of innate immune sensors by viruses and self" -1er Février 2019
  • Dr. Carocci Margot (INSERM UMR-949, Université de Strasbourg) "Development of novel strategies to fight flaviviruses: from targeted screen to in vivo antiviral validation" - 7 Décembre 2018
  • Dr. Cimarelli Andrea (Inserm U1111 - CNRS UMR 5308 - Université / ENS de Lyon) "Interferon-stimulated transmembrane proteins (ifitms) as a novel paradigm of restriction factors targeting the in and out of a viral life cycle" - 14 Novembre 2018
  • Dr. Margottin-Goguet Florence (Institut Cochin - Paris) "HIV Latency as an intrinsic host defense antagonized by lentiviral proteins" - 21 Septembre 2018
  • Dr. Oehlers Stefan (Centenary Institute - University of Sidney) "Vascular control of mycobacterial immunity" - 6 Juillet 2018
  • Dr. Shu Sin Chng (Department of Chemistry, National University of Singapore) "Bacterial lipid trafficking and outer membrane homeostasis"
  • Prof. Slupphaug Geir (Department of Clinical and Molecular Medicine, Trondheim, Norway) "Are endogenous and chemically induced base methylations in human mRNA processed differentially?"
  • Dr. Chojnacki Jakub (IrsiCaixa AIDS research institut - Barcelona) "STED microscopy studies of HIV-1 dynamic structure and virus-cell interactions."
  • Dr. Gaudin Raphaël (Inserm U1110 - Strasbourg) "Zika virus induces monocyte transmigration, spreading the infection to the brain"
  • Dr. Muriaux D.  (CEMIPAI) "Présentation de la plateforme CEMIPAI et ses technologies innovantes"
  • Prof. Yegutgin G. (University of Turku - Finland) "Emerging roles of purine-converting ectoenzymes in inflammation and tumorigenesis"
  • Dr. Smyth R. (IBMC, Strasbourg)
  • Dr. Lyonnais S. (IBMB-CSIC, Barcelone)
  • Dr. Long J. (Imperial College of London)
  • Dr. Meunier E. (IPBS, Toulouse)
  • Dr. Herbeuval J.P. (UMR 8601, Paris)
  • Dr. Wodrich G. (UMR 5234, Bordeaux)
  • Dr. Henriet S. (University of Bergen, Norway)
  • Dr. Janvier K. (Institut Cochin, Paris)








Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5