The IRIM MDVA team (D. Muriaux – C. Favard) contributes to an article published in Science (IF=41.8) by M. Lagha’s team at the IGMM
This study, about imaging the translation of mRNA into proteins in the developing Drosophila embryo, is a federative work involving the three biology laboratories located on the Montpellier CNRS site, Route de Mende.
The translation of mRNA into proteins had never been imaged before in multicellular organisms. J. Dufourt, M. Bellec and M. Lagha engineered the SunTag method to visualise the timing and the localisation of single mRNAs on going translation in living Drosophila embryos. Thanks to the expertise in fluorescence correlation, quantitative imaging and single particle dynamics of D. Muriaux and C. Favard’s team, the translation kinetics of these single sRNAs has been quantified in the developing living embryo. The observation of the localisation and dynamics of mRNA translation in a living multicellular organism thus opens up numerous perspectives for understanding various processes related to the spatio-temporal regulation of the translation of endogenous (cellular) or exogenous (viral) proteins.
