Position
INSERM Tenure Researcher
HDR
Equipe
Mycobacterial Pathogenesis and Novel Therapeutic Targets
Contact
email : wassim.daher(at)irim.cnrs.fr
Phone : +33 (0)4 34 35 94 45
Publications (last 5 years)
2024
Loss of LpqM proteins in Mycobacterium abscessus is associated with impaired intramacrophage survival.
Y.-M. Boudehen, W. Daher, F. Roquet-Baneres, and L. Kremer. 2024. mSpectrum. In Press.
2023
Multiple Mycobacterium abscessus O-acetyltransferases influence glycopeptidolipid structure and colony morphotype.
M. Illouz, L.-D. Leclercq, C. Dessenne, G. Hatfull, W. Daher, L. Kremer*, and Y. Guérardel*. 2023. J. Biol. Chem. 299: 104979. *Co-last corresponding authors.
Mycobacterial biotin biosynthesis counters airway alkalinity. W. Daher, and L. Kremer. 2023. Nat. Microbiol. 8: 369-370.
Mycobacterium abscessus alkylhydroperoxide reductase C promotes cell invasion by binding to tetraspanin CD81. J. Karam, F. P. Blanchet, E. Vivès, P. Boisguérin, Y.-M. Boudehen, L. Kremer*, and W. Daher*. 2023. iScience. 26, 106042. *Co-last corresponding authors.
The molecular basis and downstream immune consequences of mycobacteria-host cell interactions.
W. Daher, V. Pichler, J. Karam, O. Neyrolles, and L. Kremer. 2023. The molecular basis and downstream immune consequences of mycobacteria-host cell interactions. FEMS Microbiol. Rev. 47: fuad009.
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria.
J. Rosain, A.-L. Neehus, J. Manry, R. Yang, J. Le Pen, W. Daher, Z. Liu, Y.-H. Chan, N. Tahuil, Ö. Türel, M. Bourgey, M. Ogishi, J.-M. Doisne, H. M. Izquierdo, T. Shirasaki, T. Le Voyer, A. Guérin, P. Bastard, M. Moncada-Velez, J. E. Han, T. Khan, F. Rapaport, S.-H. Hong, A. Cheung, K. Haake, B. C. Mindt, L. Perez, Q. Philippot, D. Lee, P. Zhang, D. Rinchai, F. Al Ali, M. M. A. Ata, M. Rahman, J. N. Peel, S. Heissel, H. Molina, Y. Kendir-Demirkol, R. Bailey, S. Zhao, J. Bohlen, M. Mancini, Y. Seeleuthner, M. Roelens, L. Lorenzo, C. Soudée, M. E. J. Paz, M. L. Gonzalez, M. Jeljeli, J. Soulier, S. Romana, A.-S. L’Honneur, M. Materna, R. Martínez-Barricarte, M. Pochon, C. Oleaga-Quintas, A. Michev, M. Migaud, R. Lévy, M.-A. Alyanakian, F. Rozenberg, C. A. Croft, G. Vogt, J.-F. Emile, L. Kremer, C. S. Ma, J. H. Fritz, S. Lemon, A. N. Spaan, N. Manel, L. Abel, M. R. MacDonald, S. Boisson-Dupuis, N. Marr, S. G. Tangye, J. P. Di Santo, Q. Zhang, S.-Y. Zhang, C. M. Rice, V. Béziat, N. Lachmann, D. Langlais, J.-L. Casanova, P. Gros, and J. Bustamante. 2023. Cell. 186: 1-25.
2022
The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness.
Lagune, V. Le Moigne, M. D. Johansen, F. V. Sotomayor, W. Daher, C. Petit, G. Cosentino, L. Paulowski, T. Gutsmann, M. Wilmanns, F. P. Maurer, J.-L. Herrmann, F. Girard-Misguich, and L. Kremer. 2022. PLOS Pathog. 18: e1010771.
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.
Riward A Campelo Morillo, Xinran Tong, Wei Xie, Steven Abel, Lindsey M Orchard, Wassim Daher, Dinshaw J Patel, Manuel Llinás, Karine G Le Roch, Björn F C Kafsack. 2022. Nat. Microbiol. 7(2):289-299.
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus.
W. Daher, L.-D. Leclercq, M. D. Johansen, C. Hamela, J. Karam, X. Trivelli, J. Nigou, Y. Guérardel, and L. Kremer. 2022. Cell Chem. Biol. 29: 1-15.
2020
The roles of tetraspanins in bacterial infections.
Karam J, Méresse S, Kremer L, Daher W.
Cell Microbiol. 2020 Sep 9:e13260. doi: 10.1111/cmi.13260.
O-Methylation of the glycopeptidolipid acyl chain defines surface hydrophobicity of Mycobacterium abscessus and macrophage invasion.
Daher W, Leclercq LD, Viljoen A, Karam J, Dufrêne YF, Guerardel Y, Kremer L.
ACS Infect Dis. 2020 Aug 28. doi: 10.1021/acsinfecdis.0c00490.
Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus.
Johansen MD, Daher W, Roquet-Banères F, Raynaud C, Alcaraz M, Maurer FP, Kremer L.Antimicrob Agents Chemother. 2020 Aug 17:AAC.00363-20. doi: 10.1128/AAC.00363-20.
Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus.
Raynaud C, Daher W, Roquet-Banères F, Johansen MD, Stec J, Onajole OK, Ordway D, Kozikowski AP, Kremer L.
Antimicrob Agents Chemother 2020 Feb 10. pii: AAC.02548-19. doi: 10.1128/AAC.02548-19.
Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus.
Raynaud C, Daher W, Johansen MD, Roquet-Banères F, Blaise M, Onajole OK, Kozikowski AP, Herrmann JL, Dziadek J, Gobis K, Kremer L.
ACS infectious diseases ACS Infect Dis 2020 Jan 7. doi: 10.1021/acsinfecdis.9b00389.
2019
Improved activity of bedaquiline by verapamil against Mycobacterium abscessus in vitro and in macrophages.
Viljoen A, Raynaud C, Johansen MD, Roquet-Banères F, Herrmann JL, Daher W, Kremer L.
Antimicrobial agents and chemotherapy. 2019 Jun 17. pii: AAC.00705-19. doi: 10.1128/AAC.00705-19.
