Position
Director of Research CNRS – HDR
Team
Transcription and antibiotics resistance
Contact
email : laurent.chaloin(at)irim.cnrs.fr
Tel : 04 34 35 94 66
Research projects:
1) Molecular mechanisms involved in antibiotics resistance, repurposing of antibiotics
2) Development of large spectrum antiviral compounds
5 relevant publications :
- Jansen M., Strub J.-M., Chaloin L., Coopman P. and Beaumelle B. “Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation” Life Science Alliance (2026) doi.org/10.26508/lsa.202503500
- Gheeraert A., Leroux V., Mias-Lucquin D., Vuillon L., Chauvot de Beauchêne I., Devignes M.-D., Rivalta I., Maigret B. and Chaloin L. “Subtle changes at the RBD/hACE2 interface during SARS-CoV-2 variant evolution: a molecular dynamics study” Biomolecules (2025) doi.org/ 10.3390/biom15040541
- Boulay A., Quevarec E., Malet I., Nicastro G., Chamontin C., Perrin S., Henriquet C., Pugnière M., Courgnaud V., Blaise M., Marcelin A-G., Taylor I., Chaloin L. and Arhel N.J. “A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import” EMBO Molecular Medicine (2024). doi:10.1038/s44321-024-00143-w
- Tram J., Marty L., Mourouvin C., Abrantes M., Jaafari I., Césaire R., Hélias P., Barbeau B., Mesnard J.-M., Baccini V., Chaloin L., Peloponese J.-M. Jr. « The oncoprotein Fra-2, a key player in the molecular mechanisms of Adult T-cell leukemia/Lymphoma (ATLL), drives the activation of HERV env expression in ATLL patients. Cell (2024) 13, 1517. doi:10.3390/cells13181517
- Morichaud Z., Trapani S., Vishwakarma R., Chaloin L., Lionne C., Lai-Kee-Him J., Bron P. and Brodolin K. “Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization” Nat. Commun. 14, 484 (2023). doi: 10.1038/s41467-023-36113-y