CHALOIN Laurent

Position

Director of Research CNRS – HDR

Team

Bacterial Enzymes and Antibiotics Resistance

Contact

email : laurent.chaloin(at)irim.cnrs.fr

Tel : 04 34 35 94 66

Research projects:

1) Molecular mechanisms involved in antibiotics resistance, repurposing of antibiotics

2) Development of large spectrum antiviral compounds

5 relevant publications :

1. Rahimova R, Fontanel S, Lionne C, Jordheim LP, Peyrottes S, Chaloin L. “Identification of allosteric inhibitors of the ecto-5′-nucleotidase (CD73) targeting the dimer interface” PLoS Comput Biol. (2018), 14:e1005943. Pubmed
2. Leban, N., Kaplan E., Chaloin L., Godreuil S. and Lionne C. “Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases” Biochim Biophys Acta. (2017), 1861, 3464-3473. Pubmed
3. Morichaud Z., Chaloin L. and Brodolin K. “Regions 1.2 and 3.2 of the RNA polymerase subunit promote DNA melting and attenuate action of the antibiotic lipiarmycin.” J. Mol. Biol. (2016) 428, 463-76, doi: 10.1016/j.jmb.2015.12.017. Pubmed
4. Marton Z., Guillon R., Krimm I., Preeti, Rahimova R., Egron D., Jordheim L.P., Aghajari N., Dumontet C., Périgaud C., Lionne C., Peyrottes S. and Chaloin L. “Identification of non-competitive inhibitors of cytosolic 5′-nucleotidase II using a fragment-based approach.” Med Chem. (2015) 58, 9680-96  Pubmed
5. Jordheim, L.P. and Chaloin L. “Therapeutic perspectives for cN-II in cancer” Current Medicinal Chemistry (2013), 20, 4292-4303. Pubmed