The work of Caroline Goujon’s team on SARS-CoV-2 makes the cover of Journal of Virology (Rebendenne et al., 2021)
In this article published in Journal of Virology, the “interferon and antiviral restriction” team led by Caroline Goujon, studied the establishment and the role of the interferon response in the control of SARS-CoV-2 replication in human epithelial pulmonary cells, which are the main targets for SARS-CoV-2.
In this article published in Journal of Virology, the “interferon and antiviral restriction” team led by Caroline Goujon, studied the establishment and the role of the interferon response in the control of SARS-CoV-2 replication in human epithelial pulmonary cells, which are the main targets for SARS-CoV-2. This interferon response is crucial for the establishment of an antiviral state in infected and neighboring cells.
The authors notably showed that primary human airway epithelial cells and human cell lines from pulmonary origin elicited a robust production of type I and III interferons, which is dependent on the RNA sensor MDA-5. However, this interferon response arrived too late and was unable to control viral replication, suggesting a timing issue.
