Raphaël GAUDIN publishes an article in Science Advances (IF=13.1)
Raphaël GAUDIN publishes an article in Science Advances (IF=13.1): Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway (Deffieu et al, 2021).
How a neosynthesized protein traffics to its final destination within a cell is a challenging question to address because of the numerous intracellular trafficking routes that co-exist in the cytoplasme.
A study led by Maïka Deffieu and Raphael Gaudin at IRIM, and recently published in Science Advances, reports on the role of Rab7, a small Rab GTPase signaling protein, in the biosynthetic secretory pathway. The team combined advanced technologies, including RUSH, CRISPR/Cas9, differential proteomics and high-resolution live cell imaging to uncover a new role for Rab7 in the biosynthetic pathway, highlighting the diversity of the secretory vesicles’ nature. Whether and how viruses subvert this pathway remains to be investigated.
