Position
Research Director INSERM
HDR Bacteriology
Team
Cellular and Molecular Biology of Bacterial Infections
Contact
email : stephan.kohler(at)irim.cnrs.fr
Tél : 04 34 35 94 59
Publications
Ouahrani-Bettache S, Jiménez de Bagüés MP, Jorge De La Garza, Freddi L, Juan P. Buezo, Sebastien Lyonnais, Al Dahouk, de Biase D, Köhler S, Occhialini A. Lethality of Brucella microti in a murine modele of infection depends on the wbkE gene involved in O-polysaccharide synthesis. Virulence, 2019, 10: 268-278.
Abdou E, Jiménez de Bagüés MP, Martínez-Abadía I, Ouahrani-Bettache S, Pantesco V, Occhialini A, Al Dahouk S, Köhler S, Jubier-Maurin V. RegA plays a key role in oxygen-dependent establishment of persistence and in isocitrate lyase activity, a critical determinant of in vivo Brucella suis pathogenicity. Front Cell Infect Microbiol, 2017, 7: 186.
Al Dahouk S, Köhler S, Occhialini A, Jiménez de Bagüés MP, Hammerl JA, Eisenberg T, Vergnaud J, Cloeckaert A, Zygmunt MS, Whatmore AM, Melzer F, Drees KP, Foster JT, Wattam AR, Scholz HC. Brucella spp. of amphibians comprise genomically diverse motile strains competent for replication in macrophages and survival in mammalian hosts. Sci Rep (Sci Rep UK), 2017, 7: 44420.
Freddi L, Damiano MA, Chaloin L, Pennacchietti E, Al Dahouk S, Köhler S, De Biase D, Occhialini A. The glutaminase-dependent system confers extreme acid resistance to new species and atypical strains of Brucella. Front Microbiol, 2017, 8: 2236.
Köhler S, Ouahrani-Bettache S, Winum JY. Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics? J Enzyme Inhib Med Chem, 2017, 32: 683-687.
Damiano MA, Bastianelli D, Al Dahouk S, Köhler S, Cloeckaert A, De Biase D, Occhialini A. Glutamate decarboxylase-dependent acid resistance in Brucella spp.: Distribution and contribution to fitness under extreme acid conditions. Appl Environ Microbiol, 2015, 81: 578-586.
Ombouma J, Vullo D, Köhler S, Supuran CT, Winum JY. N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. J Enzyme Inhib Med Chem, 2015, 30:1010-1012.
Riafrecha L, Vullo D, Ouahrani-Bettache S, Köhler S, Dumy P, Winum JY, Supuran CT, Colinas PA. Inhibition of b-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety. J Enzyme Inhib Med Chem, 2015, 30:1017-1020.
