Position
Researcher CNRS
Team
Players in the pathogenesis of the retroviral infections
Contact
email : antoine.gross[at]irim.cnrs.fr
Tél : 04 34 35 94 41
Main topic:
– Before 2008: Macrophage and Dendritic cells infection with the intracellular bacteria Brucella.
– Since 2009: Antisens proteins of retroviruses. ASP (AntiSense Protein) of HIV-1 : antisense transcription, cellular and humoral immune response againts ASP, evolutive analyses of ASP gene in SIVcpz and HIV-1, impacts of ASP on the cells and immunity, ASP-related translational researches on infected patients.
– Since 2020 : Humoral response against Spike RBD and accessory proteins in patients infected with SARS-COV2.
Publications
1. Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic. Cassan E, Arigon-Chifolleau AM, Mesnard JM, Gross A, Gascuel O. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11537-11542.
2. The HIV-1 antisense protein (ASP) induces CD8 T cell responses during chronic infection. Bet A, Maze EA, Bansal A, Sterrett S, Gross A, Graff-Dubois S, Samri A, Guihot A, Katlama C, Theodorou I, Mesnard JM, Moris A, Goepfert PA, Cardinaud S. Retrovirology. 2015 Feb 10;12:15.
3. HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup. Debaisieux S, Lachambre S, Gross A, Mettling C, Besteiro S, Yezid H, Henaff D, Chopard C, Mesnard JM, Beaumelle B. Nat Commun. 2015 Feb 4;6:6211.
4. Construction of a reporter vector for analysis of bidirectional transcriptional activity of retrovirus LTR. Arpin-André C, Laverdure S, Barbeau B, Gross A, Mesnard JM. Plasmid. 2014 Jul;74:45-51. doi: 10.1016/j.plasmid.2014.06.001.
5. Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. Sarkis S, Belrose G, Peloponese JM Jr, Olindo S, Césaire R, Mesnard JM, Gross A. J Clin Virol. 2013 Sep;58(1):295-8.
6. HIV-1 antisense transcription is preferentially activated in primary monocyte-derived cells. Laverdure S, Gross A, Arpin-André C, Clerc I, Beaumelle B, Barbeau B, Mesnard JM. J Virol. 2012 Dec;86(24):13785-9. doi: 10.1128/JVI.01723-12.
7. Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells. Clerc I, Laverdure S, Torresilla C, Landry S, Borel S, Vargas A, Arpin-André C, Gay B, Briant L, Gross A, Barbeau B, Mesnard JM. Retrovirology. 2011 Sep 19;8:74.
8. Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes. Belrose G, Gross A, Olindo S, Lézin A, Dueymes M, Komla-Soukha I, Smadja D, Tanaka Y, Willems L, Mesnard JM, Peloponese JM Jr, Césaire R. Blood. 2011 Sep 1;118(9):2483-91.
