Caroline GOUJON has been awarded an ERC StG 2017 for the ANTIViR project (Mechanisms of interferon-induced antiviral restriction and signaling)
Research project
Caroline Goujon’s project aims at providing a better understanding of the interferon-induced, natural defences against human pathogenic viruses. Interferon is produced by infected cells following the detection of pathogenic viruses and bacteria and is the first line of defense against infection. Interferon induces several hundred genes both in infected and bystander cells and induced an antiviral state. The ANTIViR project aims at characterizing the effectors of this antiviral state and the mechanisms of the antiviral restriction. HIV-1 and influenza A virus are both sensitive to the interferon-induced antiviral state in human cells, partly because of the activity of the Mx GTPases (MX1 and MX2). The project aims at understanding the mechanism of action of the Mx proteins and at identifying and characterizing new actors of the antiviral state against these human pathogenic viruses, using powerful approaches such as whole-genome scale CRISPR/Cas9 genetic screens.
Link to the team website
Interféron et restriction antivirale
Keywords
Interferon, HIV-1, Influenza A, restriction factors, GTPases MX1 et MX2, interferon-stimulated genes, antiviral state, innate immunity
Principales publications
1. Doyle, T., Goujon, C., and Malim, MH. (2015) HIV-1 and interferons: who’s interfering with whom? Nature Reviews Microbiology 13: 403-13.
2. Goujon, C., Greenbury, R., Papaioannou, S., Doyle, T., Malim, MH. (2015) A triple arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2. J. Virol. 89: 4676-80.
3. Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Barclay, WS., and Malim, MH. (2014) Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor. J. Virol. 88: 9017-26.
4. Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Ward, CC., Schaller, T., Hué, S., Barclay, WS., Schulz, R., and Malim, MH. (2013) Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature, 502: 559-62.
5. Goujon, C.*, Schaller, T.*, Galão, R., Olivieri, K., Neil, S., and Malim, MH. (2013) Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection. Retrovirology, 10, 23.
6. Schaller, T., Goujon, C., and Malim, M.H. (2012) AIDS/HIV. HIV interplay with SAMHD1. Science, 335, 1313-1314.
