Welcome to the new IRIM’s team
Laura PICAS, a young biophysicist and CNRS CR2, joins IRIM to create the twelfth research team at IRIM thanks to ATIP-Avenir funding. Congratulations Laura!
Name of the team
Quantitative biology of membrane trafficking and pathogenesis.
Research project
Endocytosis is a fundamental cellular process that is built in the precise control of complex protein machinery that is orchestrated to achieve the remodeling of the plasma membrane. How endocytic proteins are coordinated in space and time is not well understood. The goal of Laura Picas’s project is to identify the key factors and molecular intermediates that orchestrate clathrin-mediated endocytosis, which is one of the key transport pathways in eukaryotic cells and often perturbed in cells infected with viruses or bacteria. This project follows up with her postdoc findings, which showed that PI(4,5)P2 clustering can coordinate the recruitment of proteins on membranes and that central modules involved in clathrin-mediated endocytosis can engage local segregation of PI(4,5)P2.
Keywords
Endocytosis, clathrin, PI(4,5)P2, membrane, AFM
10 main publications for the last five years
- L. Picas, Gaits-Iacovoni F and Goud B. F1000Research 2016, 5(F1000 Faculty Rev):422 (doi: 10.12688/f1000research.7537.1)
- A.Carretero-Genevrier, M.Gich, L.Picas, C.Sanchez, J.Rodriguez-Carvajal. Faraday Discussions, 2015.
- L. Picas, K. Schauer, J. Viaud, K. Hnia, A. Roux, F. Gaits-Iacovoni, B.Payrastre, J. Laporte, J.B. Manneville, B. Goud. Nature Communications, 2014.
- F. Rico, A. Rigato, L. Picas, S. Scheuring. Journal of Nanobiotechnology, 11, S3, 2013.
- F. Rico, L. Picas, A. Colom-Diego, N. Buzynskyy, S. Scheuring. Soft Matter, 9, 7866-73, 2013.
- A. Carretero-Genevrier, M. Gich, L. Picas, J. Gasquez, G. Drisko, J. Rodriguez-Carvajal, C. Boissier, D. Grosso, C. Sanchez. Science, 340, 827-31, 2013.
- L. Picas, F. Rico, M. Deforet, S. Scheuring. ACS Nano, 26, 1054-63, 2013.
- L. Picas, P.E. Milhiet, J. Hernández Borrell. Physics and Chemistry of Lipids, Volume 165, Issue 8, 845-860, 2012.
- L. Picas, F. Rico, S. Scheuring. Biophysical Journal, 102, 01-03, 2012.
- L. Picas, C. Suárez-Germà, M.T. Montero, Ò. Domènech, J. Hernández-Borrell. Langmuir, 28, 701-706, 2012.
