Post-doc/Non-permanent positions

Post-Doctoral position in phosphate homeostasis and calcification at IRIM, Montpellier, France

A post-doctoral position funded by the French National Agency of research (ANR) is open for a talented and highly motivated post-doc fellow to study cellular phosphate homeostasis and its misregulation leading to vascular calcification.

Phosphate is an important mineral for the synthesis of membranes and nucleic acids, for energy production and signal transduction, and its concentration is tightly regulated by phosphate transporters. Little is known about how human and other metazoan cells sense phosphate to regulate phosphate homeostasis and metabolism. We are particularly interested in XPR1, a retroviral receptor that we found to mediate phosphate efflux and to be associated with a rare disease called primary familial brain calcification (PFBC). The objective of the post-doctoral project is to understand how XPR1 is integrated in this regulated sensing process and why mutations in the XPR1 gene can lead to phosphate-associated disorders like calcification. The successfull applicant will use a broad range of technics, in particular genome modifications and genetic screens, solute transport assays, as well as calcification assays in in vitro and in vivo models..

1- Giovannini D., Touhami J., Charnet P., Sitbon M.*, Battini JL.* 2013. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. 2013. Cell Reports 3: 1866-73.
2-  Legati A., Giovannini D., …, Geschwind DH., Battini JL.*, Coppola G*. 2015. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nature Genetics 47: 579–581.

Context:

The candidate will be part of the CALCIPHOS ANR project, organized as an interdisciplinary research program between the Labs of Jean-Luc Battini/Laurence Briant (IRIM, CNRS UMR9004, Montpellier), Marc Sitbon (IGMM, CNRS UMR5535, Montpellier) and Gaël Nicolas/Dominique Campion (INSERM U1245, Rouen). She/he will benefit from a highly dynamic and collaborative environment at the « route de Mende » CNRS campus of Montpellier and from state-of-the-art technological platforms.

Profil:

Candidates are expected to be autonomous, enthusiastic, and able to work in a collaborative team. Experience in cell and molecular biology, biochemistry and imaging is required as well as good communication skills in english. An expertise in animal studies and histology as well as a background in calcification/mineralization would be appreciated. The position is funded for 2 years and salary will be based on experience.

Applicants must hold a PhD degree in biology and should send a letter of scientific achivements and of their interest in this project, a CV with list of publications, and contact informations of 2 referees to This email address is being protected from spambots. You need JavaScript enabled to view it.

Deadline: December 2017    

Starting: January / February 2018

 

   


 

L. Chaloin (Equipe K. Brodolin) recherche un post-doc en modélisation / chémoinformatique pour 18 mois dans le cadre d'un projet financé par l'INCa.

A post-doctoral position funded by the French National Institute of Cancer (INCa) is open for a talented and highly motivated post-doctoral fellow to design and optimize lead compounds targeting an ectoenzyme involved in the anticancer immune response.

In the context of the tumor microenvironment and the anticancer immune response, several key enzymes from the nucleotide metabolism are contributing negatively to this natural defense leading to tumor progression and invasion. The research project will focus on new hit identification by virtual screening, in vitro evaluation of the target enzyme and lead optimization by using chemoinformatics approaches (pharmacophore models, scaffold hopping…) of already identified leads.

Applicants must hold a PhD degree in Biochemistry or Bioinformatics or Chemoinformatics. Little knowledge in enzymology would be appreciated but not required. Application should be sent by email (CV with scientific achievements, motivation + recommendation letter) by email to This email address is being protected from spambots. You need JavaScript enabled to view it..

Deadline: November 30th 2017    

Starting: January 8th 2018

     

 


L'équipe de Laurent Kremer recherche un post-doc en mycobactériologie pour 2 ans dans le cadre d'un projet financé par le LabEx EpiGenMed.

La paroi mycobactérienne représente une structure complexe constituée de lipides atypiques qui agissent comme immunomodulateurs et facteurs de virulence. Une meilleure compréhension des enzymes impliquées dans l’export de ces lipides nous renseignerait sur la biogenèse de la paroi.

Nous avons récemment obtenu des informations fonctionnelles et structurales sur une famille de transporteurs lipidiques, les protéines de la famille MmpL, qui appartiennent à la superfamille des pompes à efflux. Mycobacterium abscessus, un pathogène émergent dans la mucoviscidose possède au moins 29 MmpLs dont les fonctions restent largement inexplorées. Ce projet consistera à générer des mutants dans des gènes codant des MmpLs et d’analyser leur phénotype en relation avec (i) la biosynthèse de la paroi ; (ii) la contribution individuelle de chacun de ces transporteurs dans la phagocytose et la survie intramacrophagique; (iii) leur rôle dans physiopathologie des infections à M. abscessus dans l’embryon de zebrafish; (iv) leur implication dans la résistance/susceptibilité aux antibiotiques.

     

 

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer


     
       

   

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer