POSTE de CDD DANS L’EQUIPE de Nathalie ARHEL : Trafic viral, restriction et immunité innée
The VTRIS team (Viral Trafficking Restriction and Innate Signaling) studies the crosstalk between viruses and innate immune responses with a particular interest in nuclear pore architecture and nucleo-cytoplasmic trafficking. We have a 12-month vacancy for a research assistant or technician (Bac +3) to support the team’s efforts in identifying novel antivirals that target nuclear import.
The responsibilities of the post are to provide support for the team’s research efforts by performing experiments, providing assistance for students and interns, and helping with general tasks such as ordering products and keeping track of laboratory stocks. The post involves work in L2 and L3 security laboratories, for which the appointee will receive adapted protective wear and training. Previous experience in biochemistry, cellular or molecular biology is essential.
The post offers the possibility to work in a dynamic and supportive academic environment at the research institute IRIM located in the South of France. Montpellier is a vibrant and young city, with many research institutes and technological platforms, making it an ideal environment to do good research. The institute welcomes international applicants; most meetings are in English and speaking French is not mandatory.
If you enjoy working in a team, and are committed to high standards of research, we encourage you to apply! Please send a CV and cover letter to
This email address is being protected from spambots. You need JavaScript enabled to view it. . We actively support equality, diversity and inclusion. Salary 1,900-2,300 €/month, depending on experience.
PLUS D'INFOS
Post-doctoral position in the VTRIS Team on Innate immunity to arbovirus infections
A two-year post-doctoral position is currently available in the VTRIS team « Viral trafficking, restriction and innate signaling » at IRIM, Montpellier, France. Our team is interested in the interplay between viruses and innate immunity, both at the level of innate immune cells (dendritic cells, macrophages, innate lymphoid cells) and at the level of signaling pathways that are triggered by foreign pattern recognition within cells. We have a particularly strong interest in arboviruses that are spread by mosquitoes, including West Nile, Usutu, Zika and Dengue viruses.
We are seeking a highly motivated candidate, with a strong background in virology and/or innate immunity. The applicants are expected to have excellent technical, organization and communication skills. A strong interest in emerging viruses, the ability to perform creative and independent research and self-motivation are essential.
Funding is available for 2 years by the French agency for research (ANR). Salary will be adjusted depending on experience. Starting date: Early 2022.
Candidates should send their applications with a complete CV and contact details for 2 referees by email to
This email address is being protected from spambots. You need JavaScript enabled to view it.
MORE DETAILS
POST-DOC POSITION IN MOUGEL’s TEAM (R2D2) IN VIRUS-CELL INTERACTION AND REAL-TIME MICROSCOPY
We are looking for an outstanding, highly-motivated candidate to join our team to develop a new project entitled: « Real time imaging of single viral RNA translation: understanding further how murine leukemia viruses (MLV) hijack the cellular pathways! ».
Understanding how retroviruses manipulate the cellular functions to replicate is crucial to design anti-viral therapies. Research project will aim to set up advanced technologies of real-time fluorescence microscopy (SunTag, SunRISE) at the scale of single molecule of viral RNA to understand MLV expression in cells. The project will be realized with the collaboration of Philippe Pierre’s lab in Marseille who have developed these techniques.
Candidates bringing expertise in fluorescence microscopy and image analysis are particularly welcome to apply. Prior research experience on virology would be an asset, but is not essential.
Starting date end 2019 (very flexible); 2-year contract financed by Infectiopole Sud.
Visit Infectiopole website for more information on eligibility criteria: www.infectiopolesud.com/bourses.html
Please send your full application including motivation letter, CV and university marks (notes and ranking), list of publications and the names and email addresses of 2-3 referees to:
This email address is being protected from spambots. You need JavaScript enabled to view it. as a single PDF file with "Postdoc application" in the subject.
Post-doc position in cell biology - EV biology – membrane trafficking
We are looking for a motivated post-doctoral scientist to join the research team “Membrane dynamics & viruses” (MDV) headed by Raphael Gaudin, part of the IRIM UMR9004 - CNRS research institute, Montpellier, France. Our lab is interested in various aspects of intracellular trafficking pathways in health and disease. In particular, we are currently studying secretion of biological entities out of the cells, including extracellular vesicles and viruses. We recently discovered a novel extracellular vesicle subtype containing Sonic Hedgehog (Shh) we called ART-EVs (Coulter, Dorobantu et al. Cell Rep, 2018) and we aim to better characterize these vesicles and their secretory route. The proposed project will take advantage of state-of-the-art imaging techniques, Crispr-Cas9 strategies and other innovative approaches mastered in the lab.
The successful candidate is expected to perform bench work and communicate his/her results through internal and external seminars. The project will be conducted in collaboration with two other labs with in vivo and proteomics expertise.
You are going to defend or already hold a PhD in Cell biology with experience in membrane trafficking. Previous experience with exosomes or extracellular vesicles is a plus. You are curious, motivated and have a problem-solving mindset. The applicant is expected to speak English, while French is not a prerequisite.
http://www.irim.cnrs.fr/index.php/en/researchh/teams/membrane-dynamics-viruses
The contract is for 1-year renewable. Starting date early-mid 2019. Applications must be sent to R. Gaudin:
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3-year postdoc position available on innate immunity and viruses Interferon and Antiviral Restriction Lab (C. Goujon’s team)*
Institut de Recherche en Infectiologie de Montpellier, France
The Interferon and Antiviral Restriction Lab, led by Caroline Goujon, is recruiting a talented and highly motivated postdoctoral fellow with expertise in the fields of innate immunity and/or virology to work on the ANTIViR ERC-funded project. This project aims at understanding the mechanisms of interferon-induced antiviral restriction and signaling, focusing on two major pathogenic viruses, HIV-1 and influenza A virus.
Applicants must hold a PhD degree in Life sciences. An excellent knowledge of influenza A virus biology and/or innate immunity is absolutely required, and expertise in super resolution microscopy and/or bioinformatics would be a plus.
Candidates should send their application, CV (including a publication list) and contact of 2 to 3 referees to:This email address is being protected from spambots. You need JavaScript enabled to view it. Deadline: December 2018
Starting: January / February 2018
Selected publications:
Tomas Doyle, Olivier Moncorgé, Boris Bonaventure, Darja Pollpeter, Marion Lussignol, Marine Tauziet, Luis Apolonia, Maria-Teresa Catanese, Caroline Goujon* and Michael H. Malim* (* co-senior, co-corresponding authors). The interferon inducible isoform of NCOA7 inhibits endosome-mediated viral entry. Nature Microbiology, in press (http://dx.doi.org/10.1038/s41564-018-0273-9).
Doyle, T., Goujon, C., and Malim, M.H. (2015). HIV-1 and interferons: who’s interfering with whom? Nature Reviews Microbiology 13, 403-413.
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Post-Doctoral position in phosphate homeostasis and calcification at IRIM, Montpellier, France
A post-doctoral position funded by the French National Agency of research (ANR) is open for a talented and highly motivated post-doc fellow to study cellular phosphate homeostasis and its misregulation leading to vascular calcification.
Phosphate is an important mineral for the synthesis of membranes and nucleic acids, for energy production and signal transduction, and its concentration is tightly regulated by phosphate transporters. Little is known about how human and other metazoan cells sense phosphate to regulate phosphate homeostasis and metabolism. We are particularly interested in XPR1, a retroviral receptor that we found to mediate phosphate efflux and to be associated with a rare disease called primary familial brain calcification (PFBC). The objective of the post-doctoral project is to understand how XPR1 is integrated in this regulated sensing process and why mutations in the XPR1 gene can lead to phosphate-associated disorders like calcification. The successfull applicant will use a broad range of technics, in particular genome modifications and genetic screens, solute transport assays, as well as calcification assays in in vitro and in vivo models..
1- Giovannini D., Touhami J., Charnet P., Sitbon M.*, Battini JL.* 2013. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. 2013. Cell Reports 3: 1866-73.
2- Legati A., Giovannini D., …, Geschwind DH., Battini JL.*, Coppola G*. 2015. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nature Genetics 47: 579–581.
Context:
The candidate will be part of the CALCIPHOS ANR project, organized as an interdisciplinary research program between the Labs of Jean-Luc Battini/Laurence Briant (IRIM, CNRS UMR9004, Montpellier), Marc Sitbon (IGMM, CNRS UMR5535, Montpellier) and Gaël Nicolas/Dominique Campion (INSERM U1245, Rouen). She/he will benefit from a highly dynamic and collaborative environment at the « route de Mende » CNRS campus of Montpellier and from state-of-the-art technological platforms.
Profil:
Candidates are expected to be autonomous, enthusiastic, and able to work in a collaborative team. Experience in cell and molecular biology, biochemistry and imaging is required as well as good communication skills in english. An expertise in animal studies and histology as well as a background in calcification/mineralization would be appreciated. The position is funded for 2 years and salary will be based on experience.
Applicants must hold a PhD degree in biology and should send a letter of scientific achivements and of their interest in this project, a CV with list of publications, and contact informations of 2 referees to
This email address is being protected from spambots. You need JavaScript enabled to view it. Deadline: December 2017
Starting: January / February 2018
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L'équipe de Laurent Kremer recherche un post-doc en mycobactériologie pour 2 ans dans le cadre d'un projet financé par le LabEx EpiGenMed.
La paroi mycobactérienne représente une structure complexe constituée de lipides atypiques qui agissent comme immunomodulateurs et facteurs de virulence. Une meilleure compréhension des enzymes impliquées dans l’export de ces lipides nous renseignerait sur la biogenèse de la paroi.
Nous avons récemment obtenu des informations fonctionnelles et structurales sur une famille de transporteurs lipidiques, les protéines de la famille MmpL, qui appartiennent à la superfamille des pompes à efflux. Mycobacterium abscessus, un pathogène émergent dans la mucoviscidose possède au moins 29 MmpLs dont les fonctions restent largement inexplorées. Ce projet consistera à générer des mutants dans des gènes codant des MmpLs et d’analyser leur phénotype en relation avec (i) la biosynthèse de la paroi ; (ii) la contribution individuelle de chacun de ces transporteurs dans la phagocytose et la survie intramacrophagique; (iii) leur rôle dans physiopathologie des infections à M. abscessus dans l’embryon de zebrafish; (iv) leur implication dans la résistance/susceptibilité aux antibiotiques.
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