1. Guillon R., Rahimova R., Preeti, Egron D., Rouanet S., Dumontet C., Aghajari N., Jordheim L.P., ^**Chaloin L. and Peyrottes S., “Lead optimization and biological evaluation of fragment-based cN-II inhibitors” J. Med. Chem. (2019), 168, 28-44 ^** co-corresponding authors
2. Ghoteimi R., Nguyen V.T., Rahimova R., Grosjean F., Cros-Perrial E., Uttaro J-P., Mathé C., Chaloin L., Jordheim L.P., Peyrottes S. “Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73.” ChemMedChem. (2019), 14, 1431-1443. doi: 10.1002/cmdc.201900348.
3. Fernandez J., Machado A., Lyonnais S., Chamontin C., Gärtner K., Léger T., Henriquet C., Garcia C., Portilho D.M., Pugnière M., Chaloin L., Muriaux D., Yamauchi Y., Blaise M., Nisole S., Arhel N.J. “Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating” Nature Microbiology (2019), 10.1038/s41564-019-0575-6

1. Sudalaiyadum Perumal A, Vishwakarma RK, Hu Y, Morichaud Z, Brodolin K. "RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase." Nucleic Acids Res. (2018) 46(19):10106-10118. doi: 10.1093/nar/gky714.
2. Vishwakarma RK, Cao AM, Morichaud Z, Perumal AS, Margeat E, Brodolin K. "Single-molecule analysis reveals the mechanism of transcription activation in M. tuberculosis." Sci Adv. (2018) 4 (5):eaao5498. doi: 10.1126/sciadv.aao5498. PubMed
3. Rahimova R., Fontanel S., Lionne C., Jordheim L.P., Peyrottes S. and Chaloin L. “Identification of allosteric inhibitors of the ecto-5’-nucleotidase (CD73) targeting the dimer interface”. PLoS Comp. Biol. (2018), doi 10.1371/journal.pcbi.1005943
4. Dulin D, Bauer DLV, Malinen AM, Bakermans JJW, Kaller M, Morichaud Z, Petushkov I, Depken M, Brodolin K, Kulbachinskiy A, Kapanidis AN. "Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria." Nat Commun. (2018) 9 (1):1478. doi: 10.1038/s41467-018-03902-9. PubMed

1. Duchi D, Gryte K, Robb NC, Morichaud Z, Sheppard C, Brodolin K, Wigneshweraraj S, Kapanidis AN. "Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes." Nucleic Acids Res. (2017) Nov 21. doi: 10.1093/nar/gkx1146. Pubmed
2. Leban, N., Kaplan E., Chaloin L., Godreuil S. and Lionne C. “Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases” Biochim Biophys Acta. (2017), 1861, 3464-3473. Pubmed
3. Gissot M., Hovasse A., Chaloin L., Schaeffer-Reiss C., Van Dorsselaer A. and Tomavo S. “An evolutionary conserved zinc finger protein is involved in Toxoplasma gondii mRNA nuclear export.” Cell. Microbiol. (2017) doi: 10.1111/cmi.12644. Pubmed
4. Baud A, Aymé L, Gonnet F, Salard I, Gohon Y, Jolivet P, Brodolin K, Da Silva P, Giuliani A, Sclavi B, Chardot T, Mercère P, Roblin P, Daniel R. "SOLEIL shining on the solution-state structure of biomacromolecules by synchrotron X-ray footprinting at the Metrology beamline." J Synchrotron Radiat. (2017) 24(Pt 3):576-585. doi: 10.1107/S1600577517002478.

1. Morichaud Z., Chaloin L. and Brodolin K. “Regions 1.2 and 3.2 of the RNA polymerase subunit promote DNA melting and attenuate action of the antibiotic lipiarmycin.” J. Mol. Biol. (2016) 428, 463-76. Pubmed

2. Duchi D, Bauer DL, Fernandez L, Evans G, Robb N, Hwang LC, Gryte K, Tomescu A, Zawadzki P, Morichaud Z, Brodolin K, Kapanidis AN. "RNA Polymerase Pausing during Initial Transcription". Mol Cell. (2016) - 63(6):939-50. Pubmed
   

3. Nasri A., Valverde A., Roche D.B., Desrumaux C., Clair P., Beyrem H., Chaloin L., Ghysen A. and Perrier V. “Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations” Int. J. of Mol. Sci., (2016), 17 (12). Pubmed

4. Kaplan E., Guichou J.F., Chaloin L., Kunzelmann S., Leban N., Serpersu E.H. and Lionne C. “Aminoglycoside binding and catalysis specificity of aminoglycoside 2''-phosphotransferase IVa: a thermodynamic, structural and kinetic study” Biochim Biophys Acta. (2016) 1860, 802-813. Pubmed

5. Nguyen V.T., Hospital, A., Lionne C., Jordheim L.P., Dumontet C., Périgaud C., Chaloin L. and Peyrottes S. “Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation » Beilstein J. Org. (2016), 12, 1476-1486. Pubmed

1. Marton Z., Guillon R., Krimm I., Preeti, Rahimova R., Egron D., Jordheim L.P., Aghajari N.,  Dumontet C., Périgaud C., Lionne C., Peyrottes S. and Chaloin L. “Identification of non-competitive inhibitors of cytosolic 5'-nucleotidase II using a fragment-based approach.” J. Med Chem. (2015) 58, 9680-96. Pubmed

2. Borel S., Robert-Hebmann V., Alfaisal J., Jain A., Faure M., Espert L., Chaloin L., Paillart J.-C., Johansen T. and Biard-Piechaczyk M. “HIV-1 Vif interacts with LC3 and inhibits autophagy” AIDS (2015) 29, 275-286. Pubmed

3. Cividini F., Pesi R., Chaloin L., Allegrini S., Camici M., Cros-Perrial E., Dumontet C., Jordheim L.P., Tozzi M.G. “The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor” Biochem Pharmacol. (2015) 94, 63-68. Pubmed

4. Briolotti P., Chaloin L., Balaguer P., Da Silva F., Tománková V., Pascussi J.-M., Duret C., Fabre J.-M., Ramos J., Klieber S., Maurel P., Daujat-Chavanieu M., Gerbal-Chaloin S. “Analysis of glycogen synthase kinase inhibitors that regulate cytochrome P450 expression in primary human hepatocytes by activation of β-catenin, aryl hydrocarbon receptor and pregnane X receptor signaling” Toxicol Sci. (2015) 148, 261-75. Pubmed

5. Ramya L., Gautham N., Chaloin L., Kajava A.V. “Restricted mobility of side chains on concave surfaces of solenoid proteins may impart heightened potential for intermolecular interactions.” Proteins (2015) 83, 1654-64. Pubmed

Locales

• Patrick BRON (CBS, Montpellier)
• Stephan Köhler (IRIM, Montpellier)
• Emmanuel MARGEAT (CBS, Montpellier)
• Bruno BEAUMELLE (IRIM, Montpellier)
• D. MURIAUX & C. FAVARD (IRIM, Montpellier)
• Jean-Marie PELOPONESE (IRIM, Montpellier)
• Suzanne Peyrottes (IBMM - Montpellier)
• Sébastien GRANIER (IGF, Montpellier)
• Andrey KAJAVA (CRBM, Montpellier)

Membres actuels de l’équipe

• Konstantin Brodolin – DR2 INSERM, HDR
• Mickael Blaise - DR2 CNRS, HDR
• Laurent Chaloin – DR2 CNRS, HDR
• Jean-Paul Leonetti - DR2 CNRS
• Zakia Morichaud - IE CNRS
• Ondine Duverger - Doctorante
• Julie Couston - Doctorante

L’équipe en 2016-2017:



L’équipe en 2015:

May 2019

Nous avons célébré ce mois-ci le départ de notre chère post-doctorante Ouerdia Maskri après deux années passées dans notre équipe. Son travail consistait à comprendre les mécanismes de régulation de la transcription chez MTB. Nous lui souhaitons beaucoup de succès et de réussite dans sa carrière scientifique.

Avril 2019

Nous accueillons un nouvel étudiant du Master 1 Bioinformatique de Rennes, Pierre Guéracher qui contribuera au projet "Drug discovery on nucleotidases".

Mars 2019

Une sortie en plein air jusqu'au magnifique site du "Ravin des Arcs" près de St Martin de Londres
 

Février 2019

Nous sommes heureux d'accueillir deux nouveaux étudiants de Master 2, Kévin Gawron and Florent Mir.

Mai 2018

A single-molecule analysis reveals the mechanism of transcription activation in Mycobacterium tuberculosis (Vishwakarma et al, 2018) - published by Konstantin BRODOLIN publishes in Science Advances (IF=11.5):

http://advances.sciencemag.org.insb.bib.cnrs.fr/content/4/5/eaao5498

Avril 2018