Kremer Laurent

Kremer Laurent


Team Leader

Research Director 1 INSERM



Mycobacterial Pathogenesis and Novel Therapeutic Targets


email : laurent.kremer(at)irim.cnrs.fr

Phone : +33 (0)4 34 35 94 47


ResearcherID: http://www.researcherid.com/rid/M-4935-2017

ORCID: http://orcid.org/0000-0002-6604-4458

Aviesan: http://cvscience.aviesan.fr/cv/797/laurent-kremer


Mutations in the MAB_2299c TetR regulator confer cross-resistance to clofazimine and bedaquiline in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen A, Rodriguez-Rincon D, Roquet-Baneres F, Blaise M, Everall I, Parkhill J, Floto RA, Kremer L.Antimicrob Agents Chemother. 2018 Oct 15. pii: AAC.01316-18. doi: 10.1128/AAC.01316-18.

MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family.

Dubois V, Viljoen A, Laencina L, Le Moigne V, Bernut A, Dubar F, Blaise M, Gaillard JL, Guérardel Y, Kremer L, Herrmann JL, Girard-Misguich F.
Proc Natl Acad Sci U S A. 2018 Oct 9. pii: 201812984. doi: 10.1073/pnas.1812984115

Delineating the physiological roles of the PE and catalytic domain of LipY in lipid consumption in mycobacteria-infected foamy macrophages.

Santucci P, Diomandé S, Poncin I, Alibaud L, Viljoen A, Kremer L, de Chastellier C, Canaan S.
Infect Immun. 2018 Jul 9. pii: IAI.00394-18. doi: 10.1128/IAI.00394-18.

Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus Complex.

Gutiérrez AV, Viljoen A, Ghigo E, Herrmann JL, Kremer L.
Front Microbiol. 2018 Jun 5;9:1145. doi: 10.3389/fmicb.2018.01145. eCollection 2018. Review.

Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis β-ketoacyl-acyl carrier protein reductase MabA.

Küssau T, Flipo M, Van Wyk N, Viljoen A, Olieric V, Kremer L, Blaise M.
Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):383-393. doi:10.1107/S2059798318002917.

B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections.

Rénier W, Bourdin A, Rubbo PA, Peries M, Dedieu L, Bendriss S, Kremer L, Canaan S, Terru D, Godreuil S, Nagot N, Van de Perre P, Tuaillon E.
PLoS One. 2018 Apr 30;13(4):e0196470. doi: 10.1371/journal.pone.0196470.

Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus.

Richard M, Gutiérrez AV, Viljoen AJ, Ghigo E, Blaise M, Kremer L.
Front Microbiol. 2018 Apr 5;9:649. doi: 10.3389/fmicb.2018.00649.

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms.

Malcolm KC, Caceres SM, Pohl K, Poch KR, Bernut A, Kremer L, Bratton DL, Herrmann JL, Nick JA.
PLoS One. 2018 Apr 19;13(4):e0196120. doi: 10.1371/journal.pone.0196120.

Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation.

Shalini, Viljoen A, Kremer L, Kumar V.
Bioorg Med Chem Lett. 2018 Mar 8. pii: S0960-894X(18)30200-2. doi:10.1016/j.bmcl.2018.03.021.

A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants.

Viljoen A, Gutiérrez AV, Dupont C, Ghigo E, Kremer L.
Front Cell Infect Microbiol. 2018 Mar 14;8:69. doi: 10.3389/fcimb.2018.00069.

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F.
Proc Natl Acad Sci U S A. 2018 Jan 17. pii: 201713195. doi:10.1073/pnas.1713195115.

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L.
J Biol Chem. 2018 Feb 23;293(8):2755-2769. doi: 10.1074/jbc.RA117.000760. Epub 2018 Jan 4.

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.

Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S.

Sci Rep. 2017 Sep 18;7(1):11751. doi: 10.1038/s41598-017-11843-4.

Controlling Extra- and Intramacrophagic <i>Mycobacterium abscessus</i> by Targeting Mycolic Acid Transport.

Viljoen A, Herrmann JL, Onajole OK, Stec J, Kozikowski AP, Kremer L.

Front Cell Infect Microbiol. 2017 Sep 1;7:388. doi: 10.3389/fcimb.2017.00388. eCollection 2017.

Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry.

Fu J, Fu H, Dieu M, Halloum I, Kremer L, Xia Y, Pan W, Vincent SP.

Chem Commun (Camb). 2017 Sep 14. doi: 10.1039/c7cc05251k.

Azide-alkyne cycloaddition en route to 4-aminoquinoline-ferrocenylchalcone conjugates: synthesis and anti-TB evaluation.

Singh A, Viljoen A, Kremer L, Kumar V.

Future Med Chem. 2017 Sep 4. doi: 10.4155/fmc-2017-0098.

Bedaquiline inhibits the ATP synthase in <i>Mycobacterium abscessus</i> and is effective in infected zebrafish.

Dupont C, Viljoen A, Thomas S, Roquet-Banères F, Herrmann JL, Pethe K, Kremer L.

Antimicrob Agents Chemother. 2017 Aug 14. pii: AAC.01225-17. doi: 10.1128/AAC.01225-17.

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.

Kozikowski AP, Onajole OK, Stec J, Dupont C, Viljoen A, Richard M, Chaira T, Lun S, Bishai W, Raj VS, Ordway D, Kremer L.

J Med Chem. 2017 Jul 13;60(13):5876-5888. doi: 10.1021/acs.jmedchem.7b00582.

Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors.

Villaume SA, Fu J, N'Go I, Liang H, Lou H, Kremer L, Pan W, Vincent SP.

Chemistry. 2017 Aug 1;23(43):10423-10429. doi: 10.1002/chem.201701812.

The Diverse Cellular and Animal Models to Decipher the Physiopathological Traits of <i>Mycobacterium abscessus</i> Infection.

Bernut A, Herrmann JL, Ordway D, Kremer L.

Front Cell Infect Microbiol. 2017 Apr 4;7:100. doi: 10.3389/fcimb.2017.00100. eCollection 2017. Review.

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.

Viljoen A, Dubois V, Girard-Misguich F, Blaise M, Herrmann JL, Kremer L.

Mol Microbiol. 2017 Jun;104(6):889-904. doi: 10.1111/mmi.13675. Epub 2017 Apr 18. Review.

Acid-Fast Positive and Acid-Fast Negative Mycobacterium tuberculosis: The Koch Paradox.

Vilchèze C, Kremer L.

Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TBTB2-0003-2015. Review.

The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium.

Pawelczyk J, Viljoen A, Kremer L, Dziadek J.

Sci Rep. 2017 Feb 16;7:42692. doi: 10.1038/srep42692.

Characterization of a mycobacterial cellulase and its impact on biofilm- and drug-induced cellulose production.

Van Wyk N, Navarro D, Blaise M, Berrin JG, Henrissat B, Drancourt M, Kremer L.

Glycobiology. 2017 May 1;27(5):392-399. doi: 10.1093/glycob/cwx014.

Binding of NADP+ triggers an open-to-closed transition in a mycobacterial FabG β-ketoacyl-ACP reductase.

Blaise M, Van Wyk N, Banères-Roquet F, Guérardel Y, Kremer L.

Biochem J. 2017 Mar 7;474(6):907-921. doi: 10.1042/BCJ20161052.

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.

Halloum I, Viljoen A, Khanna V, Craig D, Bouchier C, Brosch R, Coxon G, Kremer L.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02509-16. doi: 10.1128/AAC.02509-16.

Inhibition of the β-Lactamase Bla<sub>Mab</sub> by Avibactam Improves the <i>In Vitro</i> and <i>In Vivo</i> Efficacy of Imipenem against Mycobacterium abscessus.

Lefebvre AL, Le Moigne V, Bernut A, Veckerlé C, Compain F, Herrmann JL, Kremer L, Arthur M, Mainardi JL.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02440-16. doi: 10.1128/AAC.02440-16.

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages.

Roux AL, Viljoen A, Bah A, Simeone R, Bernut A, Laencina L, Deramaudt T, Rottman M, Gaillard JL, Majlessi L, Brosch R, Girard-Misguich F, Vergne I, de Chastellier C, Kremer L, Herrmann JL.

Open Biol. 2016 Nov;6(11). pii: 160185.

Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking.

Bernut A, Nguyen-Chi M, Halloum I, Herrmann JL, Lutfalla G, Kremer L.

PLoS Pathog. 2016 Nov 2;12(11):e1005986. doi: 10.1371/journal.ppat.1005986. eCollection 2016

Current perspectives on the families of glycoside hydrolases of Mycobacterium tuberculosis: their importance and prospects for assigning function to unknowns.

van Wyk N, Drancourt M, Henrissat B, Kremer L.

Glycobiology. 2017 Jan;27(2):112-122. doi: 10.1093/glycob/cww099.

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts.

Singh VK, Berry L, Bernut A, Singh S, Carrère-Kremer S, Viljoen A, Alibaud L, Majlessi L, Brosch R, Chaturvedi V, Geurtsen J, Drancourt M, Kremer L.

Cell Microbiol. 2016 Nov;18(11):1489-1507. doi: 10.1111/cmi.12606.

Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis.

Santucci P, Bouzid F, Smichi N, Poncin I, Kremer L, De Chastellier C, Drancourt M, Canaan S.

Front Cell Infect Microbiol. 2016 Oct 7;6:122. eCollection 2016. Review.

Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea.

Velappan AB, Charan Raja MR, Datta D, Tsai YT, Halloum I, Wan B, Kremer L, Gramajo H, Franzblau SG, Kar Mahapatra S, Debnath J.

Eur J Med Chem. 2017 Jan 5;125:825-841. doi: 10.1016/j.ejmech.2016.09.083.

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH.

Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581.

MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus.

Viljoen A, Blaise M, de Chastellier C, Kremer L.

Mol Microbiol. 2016 Nov;102(4):611-627. doi: 10.1111/mmi.13482.

MgtC as a Host-Induced Factor and Vaccine Candidate against Mycobacterium abscessus Infection.

Le Moigne V, Belon C, Goulard C, Accard G, Bernut A, Pitard B, Gaillard JL, Kremer L, Herrmann JL, Blanc-Potard AB.

Infect Immun. 2016 Sep 19;84(10):2895-903. doi: 10.1128/IAI.00359-16.

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113.

Mycobacterium lutetiense sp. nov., Mycobacterium montmartrense sp. nov. and Mycobacterium arcueilense sp. nov., members of a novel group of non-pigmented rapidly growing mycobacteria recovered from a water distribution system.

Konjek J, Souded S, Guerardel Y, Trivelli X, Bernut A, Kremer L, Welte B, Joyeux M, Dubrou S, Euzeby JP, Gaillard JL, Sapriel G, Heym B.

Int J Syst Evol Microbiol. 2016 Sep;66(9):3694-3702. doi: 10.1099/ijsem.0.001253.

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L.

Mol Microbiol. 2016 Aug;101(3):515-29. doi: 10.1111/mmi.13406.

Use of the Salmonella MgtR peptide as an antagonist of the Mycobacterium MgtC virulence factor.

Belon C, Rosas Olvera M, Vives E, Kremer L, Gannoun-Zaki L, Blanc-Potard AB.

Future Microbiol. 2016;11(2):215-25. doi: 10.2217/fmb.15.134.

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L.

Mol Microbiol. 2016 Mar;99(5):866-83. doi: 10.1111/mmi.13283.

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos.

Bernut A, Dupont C, Sahuquet A, Herrmann JL, Lutfalla G, Kremer L.

J Vis Exp. 2015 Sep 9;(103). doi: 10.3791/53130.

The Molecular Genetics of Mycolic Acid Biosynthesis.

Pawełczyk J, Kremer L.

Microbiol Spectr. 2014 Aug;2(4):MGM2-0003-2013. doi: 10.1128/microbiolspec.MGM2-0003-2013. Review.

A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis.

Carrère-Kremer S, Blaise M, Singh VK, Alibaud L, Tuaillon E, Halloum I, van de Weerd R, Guérardel Y, Drancourt M, Takiff H, Geurtsen J, Kremer L.

Mol Microbiol. 2015 Jun;96(5):1085-102. doi: 10.1111/mmi.12992.

Mycobacterium marinum MgtC plays a role in phagocytosis but is dispensable for intracellular multiplication.

Belon C, Gannoun-Zaki L, Lutfalla G, Kremer L, Blanc-Potard AB.

PLoS One. 2014 Dec 29;9(12):e116052. doi: 10.1371/journal.pone.0116052. eCollection 2014.

β-Lactamase inhibition by avibactam in Mycobacterium abscessus.

Dubée V, Bernut A, Cortes M, Lesne T, Dorchene D, Lefebvre AL, Hugonnet JE, Gutmann L, Mainardi JL, Herrmann JL, Gaillard JL, Kremer L, Arthur M.

J Antimicrob Chemother. 2015 Apr;70(4):1051-8. doi: 10.1093/jac/dku510.

Overexpression of the Salmonella KdpF membrane peptide modulates expression of kdp genes and intramacrophage growth.

Gannoun-Zaki L, Belon C, Dupont C, Hilbert F, Kremer L, Blanc-Potard AB.

FEMS Microbiol Lett. 2014 Oct;359(1):34-41. doi: 10.1111/1574-6968.12559. Epub 2014 Sep 8.

In vitro evaluation of a new drug combination against clinical isolates belonging to the Mycobacterium abscessus complex.

Singh S, Bouzinbi N, Chaturvedi V, Godreuil S, Kremer L.

Clin Microbiol Infect. 2014 Dec;20(12):O1124-7. doi: 10.1111/1469-0691.12780.

Design, synthesis and docking studies of some novel (R)-2-(4'-chlorophenyl)-3-(4'-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents.

Barot KP, Jain SV, Gupta N, Kremer L, Singh S, Takale VB, Joshi K, Ghate MD.

Eur J Med Chem. 2014 Aug 18;83:245-55. doi: 10.1016/j.ejmech.2014.06.019.

[Mycobacterial cording: a new mechanism of immune evasion?].

Bernut A, Herrmann JL, Lutfalla G, Kremer L.

Med Sci (Paris). 2014 May;30(5):499-502. doi: 10.1051/medsci/20143005008.

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.

Vilchèze C, Molle V, Carrère-Kremer S, Leiba J, Mourey L, Shenai S, Baronian G, Tufariello J, Hartman T, Veyron-Churlet R, Trivelli X, Tiwari S, Weinrick B, Alland D, Guérardel Y, Jacobs WR Jr, Kremer L.

PLoS Pathog. 2014 May 8;10(5):e1004115. doi: 10.1371/journal.ppat.1004115. eCollection 2014 May.

In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system.

Bernut A, Le Moigne V, Lesne T, Lutfalla G, Herrmann JL, Kremer L.

Antimicrob Agents Chemother. 2014 Jul;58(7):4054-63. doi: 10.1128/AAC.00142-14.

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation.

Leiba J, Carrère-Kremer S, Blondiaux N, Dimala MM, Wohlkönig A, Baulard A, Kremer L, Molle V.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1132-8. doi: 10.1016/j.bbrc.2014.03.074.

Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant.

Cortesia C, Vilchèze C, Bernut A, Contreras W, Gómez K, de Waard J, Jacobs WR Jr, Kremer L, Takiff H.

MBio. 2014 Feb 25;5(2):e00013-14. doi: 10.1128/mBio.00013-14.

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation.

Bernut A, Herrmann JL, Kissa K, Dubremetz JF, Gaillard JL, Lutfalla G, Kremer L.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):E943-52. doi: 10.1073/pnas.1321390111.

7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation.

Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Forge D, Kumar V.

Chem Biol Drug Des. 2014 May;83(5):622-9. doi: 10.1111/cbdd.12273.

Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study.

Alibaud L, Pawelczyk J, Gannoun-Zaki L, Singh VK, Rombouts Y, Drancourt M, Dziadek J, Guérardel Y, Kremer L.

J Biol Chem. 2014 Jan 3;289(1):215-28. doi: 10.1074/jbc.M113.525550.

4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation.

Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J, Rosenthal PJ, Kumar V.

Chem Biol Drug Des. 2014 Feb;83(2):191-7. doi: 10.1111/cbdd.12225.

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D.

Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277.

Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia.

Saxena AK, Roy KK, Singh S, Vishnoi SP, Kumar A, Kashyap VK, Kremer L, Srivastava R, Srivastava BS.

Int J Antimicrob Agents. 2013 Jul;42(1):27-35. doi: 10.1016/j.ijantimicag.2013.03.007.

Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

Sambandan D, Dao DN, Weinrick BC, Vilchèze C, Gurcha SS, Ojha A, Kremer L, Besra GS, Hatfull GF, Jacobs WR Jr.

MBio. 2013 May 7;4(3):e00222-13. doi: 10.1128/mBio.00222-13.

Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.

Leiba J, Syson K, Baronian G, Zanella-Cléon I, Kalscheuer R, Kremer L, Bornemann S, Molle V.

J Biol Chem. 2013 Jun 7;288(23):16546-56. doi: 10.1074/jbc.M112.398503.

Overexpression of the KdpF membrane peptide in Mycobacterium bovis BCG results in reduced intramacrophage growth and altered cording morphology.

Gannoun-Zaki L, Alibaud L, Carrère-Kremer S, Kremer L, Blanc-Potard AB.

PLoS One. 2013;8(4):e60379. doi: 10.1371/journal.pone.0060379.

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues.

Coxon GD, Craig D, Corrales RM, Vialla E, Gannoun-Zaki L, Kremer L.

PLoS One. 2013;8(1):e53162. doi: 10.1371/journal.pone.0053162.

Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.

Corrales RM, Leiba J, Cohen-Gonsaud M, Molle V, Kremer L.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):858-64. doi: 10.1016/j.bbrc.2012.11.038.

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK.

J Biol Chem. 2013 Jan 4;288(1):382-92. doi: 10.1074/jbc.M112.419754.

Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.

Gannoun-Zaki L, Alibaud L, Kremer L.

Antimicrob Agents Chemother. 2013 Jan;57(1):629-32. doi: 10.1128/AAC.01972-12.

Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation.

Kumar K, Carrère-Kremer S, Kremer L, Guérardel Y, Biot C, Kumar V.

Dalton Trans. 2013 Feb 7;42(5):1492-500. doi: 10.1039/c2dt32148c.

MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.

Delorme V, Diomandé SV, Dedieu L, Cavalier JF, Carrière F, Kremer L, Leclaire J, Fotiadu F, Canaan S.

PLoS One. 2012;7(9):e46493. doi: 10.1371/journal.pone.0046493.

The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.

Yang Y, Labesse G, Carrère-Kremer S, Esteves K, Kremer L, Cohen-Gonsaud M, Blanc-Potard AB.

J Bacteriol. 2012 Nov;194(22):6255-63. doi: 10.1128/JB.01424-12.

Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue.

Coddeville B, Wu SW, Fabre E, Brassart C, Rombouts Y, Burguière A, Kremer L, Khoo KH, Elass-Rochard E, Guérardel Y.

J Proteomics. 2012 Oct 22;75(18):5695-705. doi: 10.1016/j.jprot.2012.07.017.

Mycobacterial lipolytic enzymes: a gold mine for tuberculosis research.

Dedieu L, Serveau-Avesque C, Kremer L, Canaan S.

Biochimie. 2013 Jan;95(1):66-73. doi: 10.1016/j.biochi.2012.07.008. Review.

Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum.

Elass-Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, Kremer L, Guérardel Y.

J Biol Chem. 2012 Oct 5;287(41):34432-44. doi: 10.1074/jbc.M112.378083.

Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.

Corrales RM, Molle V, Leiba J, Mourey L, de Chastellier C, Kremer L.

J Biol Chem. 2012 Jul 27;287(31):26187-99. doi: 10.1074/jbc.M112.373209.

Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K.

Antimicrob Agents Chemother. 2012 Aug;56(8):4140-5. doi: 10.1128/AAC.06445-11.

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone chimeric scaffolds.

Kumar K, Singh P, Kremer L, Guérardel Y, Biot C, Kumar V.

Dalton Trans. 2012 May 21;41(19):5778-81. doi: 10.1039/c2dt30514c.

CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan.

Driss V, Hermann E, Legrand F, Loiseau S, Delbeke M, Kremer L, Guerardel Y, Dombrowicz D, Capron M.

Immunol Lett. 2012 Apr 30;143(2):202-7. doi: 10.1016/j.imlet.2012.02.011.

Exposure of mycobacteria to cell wall-inhibitory drugs decreases production of arabinoglycerolipid related to Mycolyl-arabinogalactan-peptidoglycan metabolism.

Rombouts Y, Brust B, Ojha AK, Maes E, Coddeville B, Elass-Rochard E, Kremer L, Guerardel Y.

J Biol Chem. 2012 Mar 30;287(14):11060-9. doi: 10.1074/jbc.M111.327387.








Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5