Bonazzi Matteo

Bonazzi Matteo


Directeur de recherche DR2 CNRS, HDR


Cellular and Molecular Biology of Bacterial Infections


email : Matteo.bonazzi[at]irim.cnrs.fr

Tél : 04 34 35 94 59



ORCID: https://orcid.org/0000-0001-5499-8759

Burette M, Allombert J, Lambou K, Maarifi G, Nisole S, Di Russo Case E, Blanchet FP, Hassen-Khodja C, Cabantous S, Samuel J, Martinez E, Bonazzi M. Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein.  PNAS. 2020 Jun 16;117(24):13708-13718. doi: 10.1073/pnas.1914892117. Epub 2020 Jun 1. PMID: 32482853

Martinez E, Huc-Brandt S, Brelle S, Allombert J, Cantet F, Gannoun-Zaki L, Burette M, Martin M, Letourneur F, Bonazzi M, Molle V. The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5.  J Biol Chem. 2020 Apr 17. pii: jbc.RA119.010112. doi: 10.1074/jbc.RA119.010112. [Epub ahead of print] PMID:32303638

Burette M, Bonazzi M. From neglected to dissected: How technological advances are leading the way to the study of Coxiella burnetii pathogenesis. Cell Microbiol. 2020 Apr;22(4):e13180. doi:10.1111/cmi.13180. Review. PMID:32185905 

Siadous FA, Cantet F, Van Schaik E, Burette M, Allombert J, Lakhani A, Bonaventure B, Goujon C, Samuel J, Bonazzi M, Martinez E. Coxiella effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence. Autophagy. 2020 Mar 1:1-17. doi: 10.1080/15548627.2020.1728098. [Epub ahead of print] PMID:32116095 

Wachter S, Bonazzi M, Shifflett K, Moses AS, Raghavan R, Minnick MF. A CsrA-Binding, trans-Acting sRNA of Coxiella burnetii Is Necessary for Optimal Intracellular Growth and Vacuole Formation during Early Infection of Host Cells. J Bacteriol. 2019 Oct 21;201(22). pii: e00524-19. doi: 10.1128/JB.00524-19. Print 2019 Nov 15. PMID: 31451541

Martinez E, Siadous FA, Bonazzi MTiny architects: biogenesis of intracellular replicative niches by bacterial pathogens. FEMS Microbiol Rev. 2018 Mar 27. doi: 10.1093/femsre/fuy013.

Häuslein I, Cantet F, Reschke S, Chen F, Bonazzi M, Eisenreich W. Multiple Substrate Usage of Coxiella burnetii to Feed a Bipartite Metabolic Network. Front Cell Infect Microbiol. 2017 Jun 29;7:285. doi: 10.3389/fcimb.2017.00285. eCollection 2017.

Moses AS, Millar JA, Bonazzi M, Beare PA, Raghavan R. Horizontally Acquired Biosynthesis Genes Boost Coxiella burnetii's Physiology. Front Cell Infect Microbiol. 2017 May 10;7:174. doi: 10.3389/fcimb.2017.00174. eCollection 2017.

van Schaik EJ, Case ED, Martinez E, Bonazzi M, Samuel JE. The SCID Mouse Model for Identifying Virulence Determinants in Coxiella burnetii. Front Cell Infect Microbiol. 2017 Feb 3;7:25. doi: 10.3389/fcimb.2017.00025. eCollection 2017.

Larson CL, Martinez E, Beare PA, Jeffrey B, Heinzen RA, Bonazzi MRight on Q: genetics begin to unravel Coxiella burnetii host cell interactions. Future Microbiol. 2016 Jul;11:919-39. doi: 10.2217/fmb-2016-0044. Epub 2016 Jul 15. Review.

Martinez E, Allombert J, Cantet F, Lakhani A, Yandrapalli N, Neyret A, Norville IH, Favard C, Muriaux D, Bonazzi MCoxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole development. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3260-9. doi: 10.1073/pnas.1522811113. Epub 2016 May 25.

Martinez E, Cantet F, Bonazzi MGeneration and multi-phenotypic high-content screening of Coxiella burnetii transposon mutants. J Vis Exp. 2015 May 13;(99):e52851. doi: 10.3791/52851.

Duron O, Noël V, McCoy KD, Bonazzi M, Sidi-Boumedine K, Morel O, Vavre F, Zenner L, Jourdain E, Durand P, Arnathau C, Renaud F, Trape JF, Biguezoton AS, Cremaschi J, Dietrich M, Léger E, Appelgren A, Dupraz M, Gómez-Díaz E, Diatta G, Dayo GK, Adakal H, Zoungrana S, Vial L, Chevillon C. The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii. PLoS Pathog. 2015 May 15;11(5):e1004892. doi: 10.1371/journal.ppat.1004892. eCollection 2015 May.

Besteiro S, Blanc-Potard A, Bonazzi M, Briant L, Chazal N, Cornillot E, Lentini G, Matkovic R, Sanosyan A, Tuaillon E, Van de Perre P. Montpellier Infectious Diseases - Pôle Rabelais (MID) 3rd annual meeting (2014). Infect Genet Evol. 2015 Jun;32:161-4. doi: 10.1016/j.meegid.2015.03.007. Epub 2015 Mar 16.

Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015 Feb 9;212(2):165-83. doi: 10.1084/jem.20141406. Epub 2015 Jan 26.

Martinez E, Cantet F, Fava L, Norville I, Bonazzi MIdentification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screening. PLoS Pathog. 2014 Mar 20;10(3):e1004013. doi: 10.1371/journal.ppat.1004013. eCollection 2014 Mar.

Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P. A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. Traffic. 2012 Dec;13(12):1653-66. doi: 10.1111/tra.12009. Epub 2012 Oct 11.

Zizza P, Iurisci C, Bonazzi M, Cossart P, Leslie CC, Corda D, Mariggiò S. Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity. J Biol Chem. 2012 May 11;287(20):16849-59. doi: 10.1074/jbc.M111.309419. Epub 2012 Mar 5.

Law HT, Bonazzi M, Jackson J, Cossart P, Guttman JA. Nexilin is a dynamic component of Listeria monocytogenes and enteropathogenic Escherichia coli actin-rich structures. Cell Microbiol. 2012 Jul;14(7):1097-108. doi: 10.1111/j.1462-5822.2012.01781.x. Epub 2012 Mar 28.

Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P. Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. J Cell Biol. 2011 Oct 31;195(3):525-36. doi: 10.1083/jcb.201105152.

Bonazzi M, Cossart P. Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection. J Cell Biol. 2011 Oct 31;195(3):349-58. doi: 10.1083/jcb.201106011. Review. Erratum in: J Cell Biol. 2011 Dec 26;195(7):1205.

Fernandez-Garcia MD, Meertens L, Bonazzi M, Cossart P, Arenzana-Seisdedos F, Amara A. Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication. J Virol. 2011 Mar;85(6):2980-9. doi: 10.1128/JVI.02483-10. Epub 2010 Dec 29.

Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P. Entrapment of intracytosolic bacteria by septin cage-like structures. Cell Host Microbe. 2010 Nov 18;8(5):433-44. doi: 10.1016/j.chom.2010.10.009.

Dortet L, Veiga E, Bonazzi M, Cossart P. CD44-independent activation of the Met signaling pathway by HGF and InlB. Microbes Infect. 2010 Nov;12(12-13):919-27. doi: 10.1016/j.micinf.2010.07.009. Epub 2010 Jul 27.

Pizarro-Cerdá J, Bonazzi M, Cossart P. Clathrin-mediated endocytosis: what works for small, also works for big. Bioessays. 2010 Jun;32(6):496-504. doi: 10.1002/bies.200900172.

Bonazzi M, Lecuit M, Cossart P. Listeria monocytogenes internalin and E-cadherin: from bench to bedside. Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a003087. doi: 10.1101/cshperspect.a003087. Review.

Bonazzi M, Lecuit M, Cossart P. Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesis. Cell Microbiol. 2009 May;11(5):693-702. doi: 10.1111/j.1462-5822.2009.01293.x. Epub 2009 Feb 2. Review.

Bonazzi M, Veiga E, Pizarro-Cerdá J, Cossart P. Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes. Cell Microbiol. 2008 Nov;10(11):2208-22. doi: 10.1111/j.1462-5822.2008.01200.x. Epub 2008 Jul 3.

Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerdá J, Finlay BB, Kirchhausen T, Cossart P. Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe. 2007 Nov 15;2(5):340-51.

Colanzi A, Hidalgo Carcedo C, Persico A, Cericola C, Turacchio G, Bonazzi M, Luini A, Corda D. The Golgi mitotic checkpoint is controlled by BARS-dependent fission of the Golgi ribbon into separate stacks in G2. EMBO J. 2007 May 16;26(10):2465-76. Epub 2007 Apr 12.

Bonazzi M, Cossart P. Bacterial entry into cells: a role for the endocytic machinery. FEBS Lett. 2006 May 22;580(12):2962-7. Epub 2006 Apr 21. Review.













Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5