Blanchet Fabien


INSERM tenured researcher


Viral Trafficking, Restriction and Innate Signaling (VTRIS)


email : fabien.blanchet[at]irim.cnrs.fr

Tel : 04 34 35 94 56



ORCID  : 0000-0003-3168-0697

- Martin MF, Maarifi G, Abiven H, Seffals M, Mouchet N, Beck C, Bodet C, Lévêque N, Arhel NJ, Blanchet FP, Simonin Y, Nisole S. Usutu virus uses langerin as a receptor to productively infect Langerhans cells more efficiently than West Nile virus. BioRxiv, 2021.08.17.456611.

- Maarifi G, Lagisquet J, Hertel Q, Bonaventure B, Chamontin C, Fuchs K, Moncorgé O, Tauziet M, Mombled M, Papin L, Molès JP, Bodet C, Lévèque N, Gross A, Arhel N, Nisole S, Van de Perre P, Goujon C, Blanchet FPAlarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells. EMBO J. 2021, 40(16):e106540.

- Maillet S, Fernandez J, Decourcelle M, El Koulali K, Blanchet FP, Arhel NJ, Maarifi G, Nisole S. Daxx inhibits HIV-1 reverse transcription and uncoating in a SUMO-dependent manner. Viruses. 2020, 12(6):E636.

- Burette M, Allombert J, Lambou K, Maarifi G, Nisole S, Di Russo Case E, Blanchet FP, Hassen-Khodja C, Cabantous S, Samuel J, Martinez E, Bonazzi M. Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein. PNAS 2020, 117(24):13708-13718.

- Maarifi G, Czubala MA, Lagisquet J, Ivory MO, Fuchs K, Papin L, Birchall JC, Nisole S, Piguet V, Blanchet FP. Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cell Mol Immunol. 2020,17(5):547-549.

- Maarifi G, Smith N, Maillet S, Moncorgé O, Chamontin C, Edouard J, Sohm F, Blanchet FP, Herbeuval JP, Lutfalla G, Levraud JP, Arhel NJ, Nisole S. TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cellsSci Adv. 2019, 5(11):eaax3511.

- Shimauchi T, Caucheteux S, Finsterbusch K, Turpin J, Blanchet FP, Ladell K, Triantafilou K, Czubala M, Tatsuno K, Easter T, Ahmed Z, Bayliss R, Hakobyan S, Price DA, Tokura Y, Piguet V. Dendritic Cells Promote the Spread of Human T-Cell Leukemia Virus Type 1 via Bidirectional Interactions with CD4+ T Cells. J Invest Dermatol. 2019, 139(1):157-66.

- Czubala MA, Finsterbusch K, Ivory MO, Mitchell JP, Ahmed Z, Shimauchi T, Karoo ROS, Coulman SA, Gateley C, Birchall JC, Blanchet FP, Piguet V. TGFβ Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells. J Invest Dermatol. 2016, 136(10):1981-1989.

- Coulon PG, Richetta C, Rouers A, Blanchet FP, Urrutia A, Guerbois M, Piguet V, Theodorou I, Bet A, Schwartz O, Tangy F, Graff-Dubois S, Cardinaud S, Moris A. HIV-Infected Dendritic Cells Present Endogenous MHC Class II-Restricted Antigens to HIV-Specific CD4+ T Cells. J Immunol. 2016, 197(2):517-32.

- Caucheteux SM, Mitchell JP, Ivory MO, Hirosue S, Hakobyan S, Dolton G, Ladell K, Miners K, Price DA, Kan-Mitchell J, Sewell AK, Nestle F, Moris A, Karoo RO, Birchall JC, Swartz MA, Hubbel JA, Blanchet FP, Piguet V. Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1. J Invest Dermatol. 2016, 136(6):1172-81.

- Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015, 6:8620.

- Sagnier S, Daussy CF, Borel S, Robert-Hebmann V, Faure M, Blanchet FP, Beaumelle B, Biard-Piechaczyk M, Espert L. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. J Virol. 2015, 89(1):615-25.

- Morgan AH, Hammond VJ, Sakoh-Nakatogawa M, Ohsumi Y, Thomas CP, Blanchet F, Piguet V, Kiselyov K, O'Donnell VB. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biol. 2015, 4:40-47.

- Alfaisal J, Daussy CF, Blanchet FP, Espert L, Salinas S, Biard-Piechaczyk M. To eat or not to eat: the intricate relationship between autophagy and HIV-1. Current Topics in Virology. 2014, 12:23-51.

- Fielding CA, Aicheler R, Stanton RJ, Wang EC, Han S, Seirafian S, Davies J, McSharry BP, Weekes MP, Antrobus PR, Prod'homme V, Blanchet FP, Sugrue D, Cuff S, Roberts D, Davison AJ, Lehner PJ, Wilkinson GW, Tomasec P. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathog. 2014, 10(5):e1004058.

- Kaur I, Puri M, Ahmed Z, Blanchet FP, Mangeat B, Piguet V. Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina. PLoS One. 2013, 8(9):e73780.

- Malbec M, Sourisseau M, Guivel-Benhassine F, Porrot F, Blanchet F, Schwartz O, Casartelli N. HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer. Retrovirology. 2013, 10:80.

- Blanchet FP, Stalder R, Czubala M, Lehmann M, Rio L, Mangeat B, Piguet V. TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse. Retrovirology. 2013, 10:6.

- Ahmed Z, Czubala M, Blanchet F, Piguet V. HIV impairment of immune responses in dendritic cells. Adv Exp Med Biol. 2013, 762:201-38.

- Blanchet FP, Mitchell JP, Piguet V. β-TrCP dependency of HIV-1 Vpu-induced downregulation of CD4 and BST-2/tetherin. Curr HIV Res. 2012, 10(4):307-14.

- Lehmann M, Rocha S, Mangeat B, Blanchet F, Uji IH, Hofkens J, and Piguet V (2011). Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction. PLoS pathogens. 2011, 7(12):e1002456.

- Blanchet F, Moris A, Mitchell JP, Piguet V. A look at HIV journey: from dendritic cells to infection spread in CD4⁺ T cells. Curr Opin HIV AIDS. 2011, 6(5):391-7.

- Nikolic DS, Lehmann M, Felts R, Garcia E, Blanchet FP, Subramaniam S, and Piguet V. HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation. Blood. 2011, 118:4841-4852.

- Blanchet FP, Piguet V. Immunoamphisomes in dendritic cells amplify TLR signaling and enhance exogenous antigen presentation on MHC-II. Autophagy. 2010, 6(6):816-8.

- Blanchet FP, Moris A, Nikolic DS, Lehmann M, Cardinaud S, Stalder R, Garcia E, Dinkins C, Leuba F, Wu L, Schwartz O, Deretic V, Piguet V. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity. 2010, 32(5):654-69.

- Stalder R, Blanchet F, Mangeat B, Piguet V. Arsenic modulates APOBEC3G-mediated restriction to HIV-1 infection in myeloid dendritic cells. J Leukoc Biol. 2010, 88(6):1251-8.

- Sourisseau M, Schilte C, Casartelli N, Trouillet C, Guivel-Benhassine F, Rudnicka D, Sol-Foulon N, Le Roux K, Prevost MC, Fsihi H, Frenkiel MP, Blanchet F, Afonso PV, Ceccaldi PE, Ozden S, Gessain A, Schuffenecker I, Verhasselt B, Zamborlini A, Saïb A, Rey FA, Arenzana-Seisdedos F, Desprès P, Michault A, Albert ML, Schwartz O. Characterization of reemerging chikungunya virus. PLoS Pathog. 2007, 3(6):e89.

- Sol-Foulon N, Sourisseau M, Porrot F, Thoulouze MI, Trouillet C, Nobile C, Blanchet F, di Bartolo V, Noraz N, Taylor N, Alcover A, Hivroz C, Schwartz O. ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation. EMBO J. 2007, 26(2):516-26.

- Sourisseau M, Sol-Foulon N, Porrot F, Blanchet F, Schwartz O. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J Virol. 2007, 81(2):1000-12.

- Schurter BT, Blanchet F, Acuto O. Protein arginine methylation: a new frontier in T cell signal transduction. Adv Exp Med Biol. 2006, 584:189-206.

- Thoulouze MI, Sol-Foulon N, Blanchet F, Dautry-Varsat A, Schwartz O, Alcover A. Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity. 2006, 24(5):547-61.

- Moris A, Pajot A, Blanchet F, Guivel-Benhassine F, Salcedo M, Schwartz O. Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. Blood. 2006, 108(5):1643-51

- Blanchet F, Schurter BT, Acuto O. Protein arginine methylation in lymphocyte signaling. Curr Opin Immunol. 2006, 18(3):321-8.

- Blanchet F, Cardona A, Letimier FA, Hershfield MS, Acuto O. CD28 costimulatory signal induces protein arginine methylation in T cells. J Exp Med. 2005, 202(3):371-7.


Book chapters

- Papin L, Daussy CF, Alfaisal J, Espert L, Blanchet FP, Blanco J, Biard-Piechaczyk M. Autophagy and HIV infection. Encyclopedia of AIDS, Springer Press, 2015.

- Blanchet FPInflammasome and HIV. Encyclopedia of AIDS, Springer Press, 2015.













Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5