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Nisole Sébastien


Position

INSERM tenured researcher

Team leader

Team

Viral Trafficking, Restriction and Innate Signaling (VTRIS)

 

Contact

email : sebastien.nisole[at]irim.cnrs.fr

Tel : 04 34 35 94 54

Publications

ORCID  : 0000-0001-9793-419X

- Martin MF, Maarifi G, Abiven H, Seffals M, Mouchet N, Beck C, Bodet C, Lévêque N, Arhel NJ, Blanchet FP, Simonin Y, Nisole SUsutu virus uses langerin as a receptor to productively infect Langerhans cells more efficiently than West Nile virus. BioRxiv, 2021.08.17.456611.

- Maarifi G, Lagisquet J, Hertel Q, Bonaventure B, Chamontin C, Fuchs K, Moncorgé O, Tauziet M, Mombled M, Papin L, Molès JP, Bodet C, Lévèque N, Gross A, Arhel N, Nisole S, Van de Perre P, Goujon C, Blanchet FP. Alarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells. EMBO J. 2021, 40(16):e106540.

- Mac Kain A, Maarifi G, Aicher SM, Arhel NJ, Baidaliuk A, Vallet T, Tran QD, Hardy A, Chazal M, Porrot F, OhAinle M, Carlson-Stevermer J, Oki J, Holden K, Simon-Loriere E, Bruel T, Schwartz O, Jouvenet N, Nisole S, Vignuzzi M, Roesch F. Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. BioRxiv, 2021.05.06.442916.

- Gosselin-Grenet AS, Servan de Almeida R, Roumagnac P, Ayouba A, Simonin Y, Nisole S. Virus et chercheurs sous le soleil de Montpellier. Virologie. 2021, 25(S1):3-5.

- Rebendenne A, Valadão ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planès R, Nisole S, Arnaud-Arnould M, Moncorgé O, Goujon C. SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cellsJ Virol. 2021, JVI.02415-20.

- Fernandez J, Hassen-Khodja C, Georget V, Rose T, Jacob Y, Janin YL, Nisole S, Vidalain PO, Arhel NJ. Measuring the subcellular compartmentalization of viral infections by protein complementation assayPNAS 2021, 118(2):e2010524118.

- Clé M, Desmetz C, Barthelemy J, Martin MF, Constant O, Maarifi G, Foulongne V, Bolloré K, Glasson Y, De Bock F, Blaquiere M, Dehouck L, Pirot N, Tuaillon E, Nisole S, Najioullah F, Van de Perre P, Cabié A, Marchi N, Gosselet F, Simonin Y, Salinas S. Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain BarriermBio. 2020, 11(4):e01183-20.

- Sa Ribero M, Jouvenet N, Dreux M, Nisole SInterplay between SARS-CoV-2 and the type I interferon responsePLoS Pathog. 2020, 16(7):e1008737.

- Nisole S, Saulnier A, Gatignol A. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Should we target the virus, the cell or the disease? Virologie. 2020, 24(3):135-141.

- Maillet S, Fernandez J, Decourcelle M, El Koulali K, Blanchet FP, Arhel NJ, Maarifi G, Nisole SDaxx inhibits HIV-1 reverse transcription and uncoating in a SUMO-dependent manner. Viruses. 2020, 12(6):E636.

- Burette M, Allombert J, Lambou K, Maarifi G, Nisole S, Di Russo Case E, Blanchet FP, Hassen-Khodja C, Cabantous S, Samuel J, Martinez E, Bonazzi M. Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein. PNAS 2020, 117(24):13708-13718.

Martin MF, Nisole SWest Nile Virus restriction in mosquito and human cells: A virus under confinement. Vaccines. 2020, 8(2):E256.

- Maarifi G, Nisole SInterferon response: with great power comes great responsibilityMed Sci (Paris). 2020, 36(3):206-209.

- Maarifi G, Czubala MA, Lagisquet J, Ivory MO, Fuchs K, Papin L, Birchall JC, Nisole S, Piguet V, Blanchet FP. Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells. Cell Mol Immunol. 2020,17(5):547-549.

- Salinas S, Simonin Y, L'Ambert G, Nisole SCas autochtones de virus Zika en France métropolitaine : un changement de paradigme pour cet arbovirus? Virologie. 2019, 23(6):329-332.

- Maarifi G, Smith N, Maillet S, Moncorgé O, Chamontin C, Edouard J, Sohm F, Blanchet FP, Herbeuval JP, Lutfalla G, Levraud JP, Arhel NJ, Nisole STRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cellsSci Adv. 2019, 5(11):eaax3511.

- Hayek S, Pietrancosta N, Hovhannisyan AA, Alves de Sousa R, Bekaddour N, Ermellino L, Tramontano E, Arnould S, Sardet C, Dairou J, Diaz O, Lotteau V, Nisole S, Melikyan G, Herbeuval JP, Vidalain PO. Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition. Eur J Med Chem. 2019 Nov 6:111855. 

- Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJ. Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. Nat Microbiol. 2019, 4(11):1840-1850.

- Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco YB, Harms M, Mayer B, Badder-Meunier B, Quartier P, Bodemer C, Baudouin V, Dieudonné Y, Kirchhoff F, Garcia ES, Charbit B, Leboulanger N, Jahrsdörfer B, Richard Y, Korganow AS, Münch J, Nisole S, Duffy D and Herbeuval JP. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatmentScience Advances. 2019, 5(7):eaav9019.

- Hayek S, Bekaddour N, Besson L, Alves de Sousa R, Pietrancosta N, Viel S, Smith N, Jacob Y, Nisole S, Mandal R, Wishart DS, Walzer T, Herbeuval JP, Vidalain PO. Identification of primary natural killer cell modulators by chemical library screening with a luciferase based functional assay. SLAS Discovery. 2019, 24(1):25-37.

- Nisole S, Fernandez J, Maarifi G, Arhel NJ. SUMO regulates the capacity of TRIM5α to inhibit HIV-1. Med Sci (Paris). 2019, 35(2):106-109. 

- Maarifi G, Fernandez J, Portilho DM, Boulay A, Dutrieux, J, Oddos S, Butler-Browne G, Nisole S, Arhel NJ. RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun Biol. 2018, 1:193.

- Nisole SUsutu ce qui ne tue pas rend plus fortVirologie. 2018, 22(5):231-2.

- Lucas-Hourani M, Dauzonne D, Mulier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso P, Tangy F, Vidalain PO. An original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response. Antimicrob. Agents Chemother. 2017, 61(10): e00383-17.

- Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep. 2017, 7(1):2561.

- Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, Dy M, Scott-Algara D, Manoury B, Zirafi O, McCort-Tranchepain I, Durroux T, Bachelerie F, Schwartz O, Münch J, Wack A, Nisole S, Herbeuval JP. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 2017, 8:14253.

- Smith N, Vidalain PO, Nisole S, Herbeuval JP. An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF 7 pathway as a proof of concept. Sci Rep. 2016, 6:29891.

- Maarifi G, Hannoun Z, Geoffroy MC, El Asmi F, Zarrouk K, Nisole S, Blondel D, Chelbi-Alix M. MxA mediates SUMO-induced resistance to Vesicular Stomatitis Virus. J Virol. 2016, 90(14):6598-610.

- Portilho DM, Fernandez J, Ringeard M, Machado AK, Boulay A, Mayer M, Müller-Trutwin M, Beignon AS, Kirchhoff F, Nisole S, Arhel NJ. Endogenous TRIM5α function is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Reports. 2016, 14(2):355-69.

- Maillet S, Nisole SDaxx, un facteur de restriction virale à large spectre. Virologie, 2016, 20(5):261-72.

- Maarifi G, Dianoux L, Nisole S, Chelbi-Alix MK. SUMO paralogs and interferon response. Med Sci (Paris). 2016, 32(2):141-3.

- Dutrieux J, Maarifi G, Portilho DM, Arhel NJ, Chelbi-Alix MK, Nisole SPML/TRIM19-dependent inhibition of retroviral reverse-transcription by Daxx. PLoS Pathog. 2015, 11(11):e1005280.

- Maarifi G, Maroui MA, Dutrieux J, Dianoux L, Nisole S, Chelbi-Alix MK. SUMO promotes resistance to interferon. J Immunol. 2015, 195(5):2312-24.

- Dutrieux J, Portilho DM, Arhel NJ, Hazan U, Nisole STRIM5α is a SUMO substrate. Retrovirology. 2015, 12:28.

- Brantis-de-Carvalho CE, Maarifi G, Gonçalves Boldrin PE, Zanelli CF, Nisole S, Chelbi-Alix MK, Valentini SR. MxA interacts with and is modified by the SUMOylation machinery. Exp Cell Res. 2015, 330(1):151-63.

- Blondel D, Maarifi G, Nisole S, Chelbi-Alix M. Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses. Viruses. 2015, 7:3675-702.

- Zebboudj A, Maroui MA, Dutrieux J, Boukoffa C, Bourouba M, Chelbi-Alix MK, Nisole SSodium arsenite induces apoptosis and Epstein-Barr virus reactivation in lymphoblastoid cells. Biochimie. 2014, 107: 247-56.

- El Asmi F, Maroui MA, Dutrieux J, Blondel D, Nisole S, Chelbi-Alix MK. Implication of PMLIV in both intrinsic and innate immunity. PLoS Pathog. 2014, 10(2):e1003975.

- Maarifi G, Chelbi-Alix MK, Nisole SPML control of cytokine signaling. Cytokine Growth Factor Rev. 2014, 25(5):551-61.

- Maroui MA, El Asmi F, Dutrieux J, Chelbi-Alix M, Nisole SImplication of PML nuclear bodies in intrinsic and innate immunity. Med Sci (Paris). 2014, 30(8-9): 765-71.

- Nisole S, Maroui MA, Mascle XH, Aubry M, Chelbi-Alix. Differential roles of PML isoformsFrontiers in Oncology, 2013, 3:125.

- Roesch F, Meziane O, Kula A, Nisole S, Porrot F, Anderson I, Mammano F, Fassati A, Marcello A, Benkirane M, Schwartz O. Hyperthermia stimulates HIV-1 replicationPLoS Pathogens. 2012, 8(7):e1002792.

- Di Nunzio F, Félix T, Arhel NJ, Nisole S, Charneau P, Beignon AS.  HIV-derived vectors for therapy and vaccination against HIVVaccine, 2012, 30:2499-509.

- Maudet C, Bertrand M, Le Rouzic E, Lahouassa H, Ayinde D, Nisole S, Goujon C,  Cimarelli A, Margottin-Goguet F, Transy C. Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathwaysJ Biol Chem. 2011, 286(27):23742-52.

- Bergamaschi A, David A, Le Rouzic E, Nisole S, Barré-Sinoussi F, Pancino G. The CDK inhibitor p21Cip1/WAF1 is induced by FcγR activation and restricts HIV-1 replication in human macrophagesJ Virol. 2009, 83(23):12253-65.

- Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G, Nisole SHuman TRIM protein expression in response to interferonsPLoS ONE. 2009, 4(3):e4894.

- Bergamaschi A, Ayinde D, David A, Le Rouzic E, Morel M, Collin G, Descamps D, DamondA F, Brun-Vezinet F, Nisole S, Margottin-Goguet F, Pancino G, Transy C. The HIV-2 Vpx protein usurps the CUL4A-DDB1-DCAF1 ubiquitin ligase to overcome an early-acting restriction factor in macrophage infectionJ Virol. 2009, 83(10):4854-60.

- Arhel NJ, Nisole S, Carthagena L, Coutant F, Souque P, Brussel A, Estaquier J, Charneau P. Lack of Endogenous TRIM5alpha-mediated restriction in rhesus macaque antigen presenting cellsBlood. 2008, 112(9):3772-6.

- Carthagena L, Parise MC, Ringeard M, Chelbi-Alix MK, Hazan U, Nisole SImplication of TRIM5α and TRIMCyp in interferon-induced anti-retroviral restriction activitiesRetrovirology. 2008, 5(1):59.

- Delcroix-Genête D, Quan PL, Roger MG, Hazan U, Nisole S, Rousseau C. Antiviral properties of two soluble trimeric recombinant gp41 proteinsRetrovirology. 2006, 3(1):16.

- Cisse A, Darbandi-Tehrani K, Derache A, El Houry S, Marlin R, Pernet O, Nisole SLes facteurs de restriction rétrovirale: de Fv1 à TRIM5aVirologie. 2006, 10:119-27.

- Yap MW, Nisole S, Stoye JP. A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restrictionCurr Biol. 2005, 15(1):73-8.

- Nisole S, Stoye JP, Saïb A. TRIM family: Retroviral restriction and antiviral defenceNature Reviews Microbiology. 2005, 3:799-808.

- Nisole S, Lynch C, Stoye JP, Yap MW. A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1Proc Natl Acad Sci U S A. 2004, 101(36):13324-8.

- Yap MW, Nisole S, Lynch C, Stoye JP. Trim5alpha protein restricts both HIV-1 and murine leukemia virusProc Natl Acad Sci U S A. 2004, 101(29):10786-91.

- Nisole S, Saib A. Early steps of retrovirus replicative cycleRetrovirology. 2004, 1(1):9.

- Said EA, Krust B, Nisole S, Svab J, Briand JP, Hovanessian AG. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptorJ Biol Chem. 2002, 277(40):37492-502.

- Nisole S, Krust B, Hovanessian AG. Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomainsExp Cell Res. 2002, 276(2):155-73.

- Nisole S, Said EA, Mische C, Prevost MC, Krust B, Bouvet P, Bianco A, Briand JP, Hovanessian AG. The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cellsJ Biol Chem. 2002, 277(23):20877-86.

- Nisole S, Callebaut C, Briand JP, Krust B, Hovanessian AG. Inhibition of HIV infection by the cytokine midkineVirology. 2001, 281(2):248-64.

- Hovanessian AG, Puvion-Dutilleul F, Nisole S, Svab J, Perret E, Deng JS, Krust B. The cell-surface-expressed nucleolin is associated with the actin cytoskeletonExp Cell Res. 2000, 261(2):312-28.

- Nisole S, Krust B, Dam E, Bianco A, Seddiki N, Loaec S, Callebaut C, Guichard G, Muller S, Briand JP, Hovanessian AG. The HB-19 pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits attachment of T lymophocyte- and macrophage-tropic HIV to permissive cellsAIDS Res Hum Retroviruses. 2000, 16(3):237-49.

- Nisole S, Krust B, Callebaut C, Guichard G, Muller S, Briand JP, Hovanessian AG. The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycansJ Biol Chem. 1999, 274(39):27875-84.

- Seddiki N, Nisole S, Krust B, Callebaut C, Guichard G, Muller S, Briand JP, Hovanessian AG. The V3 loop-mimicking pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits HIV infection in primary macrophage culturesAIDS Res Hum Retroviruses. 1999, 15(4):381-90.

- Dumonceaux J, Nisole S, Chanel C, Quivet L, Amara A, Baleux F, Briand P, Hazan U. Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotypeJ Virol. 1998, 72(1):512-9.

 

Book chapter

- Nisole S. TRIM protein family and viral restriction. Encyclopedia of AIDS, Springer Press, 2015, Article 432925, Chapter: 383.

 

 

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

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