Espert Lucile


CNRS Researcher



Players in the Pathogenesis of the Retroviral Infections


email : lucile.espert[at]

Phone: +33 (0)4 34 35 94 55



Daniel J. Klionsky,…. Lucile Espert,…. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th Edition). Autophagy. 2021 Feb 8;1-382.

Romain Ragimbeau, Leila El Kebriti, Elise Fourgous, Abdelhay Boulahtouf, Giuseppe Arena, Lucile Espert, Nadine Houédé, Céline Gongora and Sophie Pattingre. BAG6 is a new receptor of mitophagy that induces mitochondrial fragmentation and PINK1/PARKIN signaling. FASEB J. 2021 Feb;35(2):e21361.

Coralie F Daussy, Mathilde Galais, Baptiste Pradel, Véronique Robert-Hebmann, Sophie Sagnier, Sophie Pattingre, Martine Biard-Piechaczyk and Lucile Espert. HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death. Autophagy. 2020 Oct 19:1-10.

Baptiste Pradel, Véronique Robert-Hebmann, Lucile Espert. Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses. Frontiers in Immunology. 2020 Oct 6;11:578038.

Jamal Alfaisal, Alice Machado, Mathilde Galais, Véronique Robert-Hebmann, Laetitia Arnauné-Pelloquin, Lucile Espert*, Martine Biard-Piechaczyk*. * Co-Last authors. HIV-1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells. Biol Cell. 2019 Dec;111(12):308-318

Mathilde Galais, Baptiste Pradel, Isabelle Vergne, Véronique Robert-Hebmann, Lucile Espert, Martine Biard-Piechaczyk. LAP (LC3-associated phagocytosis): phagocytosis or autophagy? Med Sci (Paris). 2019 Aug-Sep;35(8-9):635-642.

Romina Cabrera-Rodríguez, Veronique Hebmann, Silvia Marfil, María Pernas, Sara Marrero-Hernández, Cecilia Cabrera, Victor Urrea, Concepción Casado, Isabel Olivares, Daniel Márquez-Arce, Silvia Pérez-Yanes, Judith Estévez-Herrera, Bonaventura Clotet, Lucile Espert, Cecilio López-Galíndez, Martine Biard-Piechaczyk, Agustín Valenzuela-Fernández, Julià Blanco. HIV-1 envelope glycoproteins isolated from Viremic Non-Progressor individuals are fully functional and cytopathic. Sci Rep. 2019 Apr 3;9(1):5544.

Majdoul Sahila, Cosette Jérémie, Seye Ababacar Khalil, Bernard Eric, Frin Sophie, Holic Nathalie, Chazal Nathalie, Briant Laurence, Espert Lucile, Galy Anne, Fenard David. Peptides derived from evolutionarily conserved domains in Beclin-1 and Beclin-2 enhance the entry of lentiviral vectors into human cells. J Biol Chem., 2017 292(45):18672-18681.

Vergne I, Lafont F, Espert L, Esclatine A, Biard-Piechaczyk M. Autophagy, ATG proteins and infectious diseases. Med Sci (Paris). 2017 Mar;33(3):312-318.

Klionsky DJ, Abdelmohsen, … Espert L, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Apr;8(4):445-544.

Daussy CF, Beaumelle B, Espert L. Autophagy restricts HIV-1 infection. Oncotarget. 2015 Aug 28;6(25):20752-3.

Espert L, Beaumelle B, Vergne I. Autophagy in Mycobacterium tuberculosis and HIV infections. Front Cell Infect Microbiol. 2015 Jun 2;5:49.

Borel S, Robert-Hebmann V, Alfaisal J, Jain A, Faure M, Espert L, Chaloin L, Paillart JC, Johansen T, Biard-Piechaczyk M. HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy. AIDS. 2015 Jan 28;29(3):275-86.

Sagnier S, Daussy CF, Borel S, Robert-Hebmann V, Faure M, Blanchet FP, Beaumelle B, Biard-Piechaczyk M, Espert L. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. J Virol. 2015 Jan;89(1):615-25.

Borel S, Espert L, Biard-Piechaczyk M. Macroautophagy Regulation during HIV-1 Infection of CD4+ T Cells and Macrophages. Front Immunol. 2012 May 7;3:97.

Biard-Piechaczyk M, Borel S, Espert L, de Bettignies G, Coux O. HIV-1, ubiquitin and ubiquitin-like proteins: the dialectic interactions of a virus with a sophisticated network of post-translational modifications. Biol Cell. 2012 Mar;104(3):165-87.

Espert L, Biard-Piechaczyk M. Autophagy in HIV-induced T cell death. Curr Top Microbiol Immunol. 2009;335:307-21. doi: 10.1007/978-3-642-00302-8_15. Review.

Espert L, Varbanov M, Robert-Hebmann V, Sagnier S, Robbins I, Sanchez F, Lafont V, Biard-Piechaczyk M. Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection. PLoS One. 2009 Jun 3;4(6):e5787. doi: 10.1371/journal.pone.0005787.

Denizot M, Varbanov M, Espert L, Robert-Hebmann V, Sagnier S, Garcia E, Curriu M, Mamoun R, Blanco J, Biard-Piechaczyk M. HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells. Autophagy. 2008 Nov;4(8):998-1008. Epub 2008 Nov 1.

Espert L, Codogno P, Biard-Piechaczyk M. What is the role of autophagy in HIV-1 infection? Autophagy. 2008 Apr;4(3):273-5. Epub 2007 Oct 29. Review.

Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie. 2008 Feb;90(2):313-23. Epub 2007 Sep 8. Review.

Molina L, Grimaldi M, Robert-Hebmann V, Espert L, Varbanov M, Devaux C, Granier C, Biard-Piechaczyk M. Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope. Proteomics. 2007 Sep;7(17):3116-30.

Espert L, Codogno P, Biard-Piechaczyk M. Involvement of autophagy in viral infections: antiviral function and subversion by viruses. J Mol Med (Berl). 2007 Aug;85(8):811-23. Epub 2007 Mar 6. Review.

Varbanov M, Espert L, Biard-Piechaczyk M. Mechanisms of CD4 T-cell depletion triggered by HIV-1 viral proteins. AIDS Rev. 2006 Oct-Dec;8(4):221-36. Review.

Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M, Codogno P, Biard-Piechaczyk M. Autophagy and CD4+ T lymphocyte destruction by HIV-1. Autophagy. 2007 Jan-Feb;3(1):32-4. Epub 2007 Jan 14. Review.

Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M, Codogno P, Biard-Piechaczyk M. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest. 2006 Aug;116(8):2161-72.













Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5