Blaise Mickael


Charge de Recherche CR1 CNRS



Pathogénie mycobactérienne et nouvelles cibles thérapeutiques


email : mickael.blaise(at)

Tél : 04 34 35 94 47


Publications (5 dernières années )

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Viljoen A, Richard M, Nguyen PC, Fourquet P, Camoin L, Paudal RR, Gnawali GR, Spilling CD, Cavalier JF, Canaan S, Blaise M, Kremer L.

J Biol Chem. 2018 Feb 23;293(8):2755-2769. doi: 10.1074/jbc.RA117.000760. Epub 2018 Jan 4.

Bozsoki Z, Cheng J, Feng F, Gysel K, Vinther M, Andersen KR, Oldroyd G, Blaise M, Radutoiu S, Stougaard J.

Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201706795. doi: 10.1073/pnas.1706795114.

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.

Viljoen A, Dubois V, Girard-Misguich F, Blaise M, Herrmann JL, Kremer L.

Mol Microbiol. 2017 Jun;104(6):889-904. doi: 10.1111/mmi.13675. Epub 2017 Apr 18. Review.

Characterization of a mycobacterial cellulase and its impact on biofilm- and drug-induced cellulose production.

Van Wyk N, Navarro D, Blaise M, Berrin JG, Henrissat B, Drancourt M, Kremer L.

Glycobiology. 2017 May 1;27(5):392-399. doi: 10.1093/glycob/cwx014.

Binding of NADP+ triggers an open-to-closed transition in a mycobacterial FabG β-ketoacyl-ACP reductase.

Blaise M*, Van Wyk N, Banères-Roquet F, Guérardel Y, Kremer L.*

Biochem J. 2017 Mar 7;474(6):907-921. doi: 10.1042/BCJ20161052.

*corresponding author

MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus.

Viljoen A, Blaise M, de Chastellier C, Kremer L.

Mol Microbiol. 2016 Nov;102(4):611-627. doi: 10.1111/mmi.13482.

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113.

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L.

Mol Microbiol. 2016 Aug;101(3):515-29. doi: 10.1111/mmi.13406.

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L.

Mol Microbiol. 2016 Mar;99(5):866-83. doi: 10.1111/mmi.13283.

Receptor-mediated exopolysaccharide perception controls bacterial infection.

Kawaharada Y, Kelly S, Nielsen MW, Hjuler CT, Gysel K, Muszyński A, Carlson RW, Thygesen MB, Sandal N, Asmussen MH, Vinther M, Andersen SU, Krusell L, Thirup S, Jensen KJ, Ronson CW, Blaise M, Radutoiu S, Stougaard J.

Nature. 2015 Jul 16;523(7560):308-12. doi: 10.1038/nature14611.

An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.

Wong JE, Midtgaard SR, Gysel K, Thygesen MB, Sørensen KK, Jensen KJ, Stougaard J, Thirup S, Blaise M.*

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):592-605.doi:10.1107/S139900471402793X. *corresponding author

A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis.

Carrère-Kremer S, Blaise M, Singh VK, Alibaud L, Tuaillon E, Halloum I, van de Weerd R, Guérardel Y, Drancourt M, Takiff H, Geurtsen J, Kremer L.

Mol Microbiol. 2015 Jun;96(5):1085-102. doi: 10.1111/mmi.12992.

Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis.

Nemie-Feyissa D, Heidari B, Blaise M, Lillo C.

Phytochemistry. 2015 Mar;111:21-6. doi: 10.1016/j.phytochem.2015.01.004.

Critical role of zinc ion on E. coli glutamyl-queuosine-tRNA(Asp) synthetase (Glu-Q-RS) structure and function.

Ray S, Banerjee V, Blaise M, Banerjee B, Das KP, Kern D, Banerjee R.

Protein J. 2014 Apr;33(2):143-9. doi: 10.1007/s10930-014-9546-1.

Lipochitin oligosaccharides immobilized through oximes in glycan microarrays bind LysM proteins.

Maolanon NN, Blaise M, Sørensen KK, Thygesen MB, Cló E, Sullivan JT, Ronson CW, Stougaard J, Blixt O, Jensen KJ.

Chembiochem. 2014 Feb 10;15(3):425-34. doi: 10.1002/cbic.201300520. Epub 2014 Jan 16.

Fusion with anticodon binding domain of GluRS is not sufficient to alter the substrate specificity of a chimeric Glu-Q-RS.

Ray S, Blaise M, Roy B, Ghosh S, Kern D, Banerjee R.

Protein J. 2014 Feb;33(1):48-60. doi: 10.1007/s10930-013-9537-7.

Cooperative binding of LysM domains determines the carbohydrate affinity of a bacterial endopeptidase protein.

Wong JE, Alsarraf HM, Kaspersen JD, Pedersen JS, Stougaard J, Thirup S, Blaise M.

FEBS J. 2014 Feb;281(4):1196-208. doi: 10.1111/febs.12698.

Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the putative NlpC/P60 endopeptidase, TTHA0266, from Thermus thermophilus HB8.

Wong JE, Blaise M.*

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1291-4. doi: 10.1107/S1744309113027164.

*corresponding author

The embryonic expression patterns of zebrafish genes encoding LysM-domains.

Laroche FJ, Tulotta C, Lamers GE, Meijer AH, Yang P, Verbeek FJ, Blaise M, Stougaard J, Spaink HP.

Gene Expr Patterns. 2013 Oct;13(7):212-24. doi: 10.1016/j.gep.2013.02.007.














Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5