Fonctions

Chercheur postdoctorant PhD

 

Equipe

Pathogénie mycobactérienne et nouvelles cibles thérapeutiques

Contact

email : albertus.viljoen(at)irim.cnrs.fr

Tél : 04 34 35 94 48

 

Publications

Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport.

Viljoen A, Herrmann JL, Onajole OK, Stec J, Kozikowski AP, Kremer L.

Front Cell Infect Microbiol. 2017 Sep 1;7:388. doi: 10.3389/fcimb.2017.00388. eCollection 2017.

Azide-alkyne cycloaddition en route to 4-aminoquinoline-ferrocenylchalcone conjugates: synthesis and anti-TB evaluation.

Singh A, Viljoen A, Kremer L, Kumar V.

Future Med Chem. 2017 Sep 4. doi: 10.4155/fmc-2017-0098.

Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.

Dupont C, Viljoen A, Thomas S, Roquet-Banères F, Herrmann JL, Pethe K, Kremer L.

Antimicrob Agents Chemother. 2017 Aug 14. pii: AAC.01225-17. doi: 10.1128/AAC.01225-17.

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.

Kozikowski AP, Onajole OK, Stec J, Dupont C, Viljoen A, Richard M, Chaira T, Lun S, Bishai W, Raj VS, Ordway D, Kremer L.

J Med Chem. 2017 Jul 13;60(13):5876-5888. doi: 10.1021/acs.jmedchem.7b00582.

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.

Viljoen A, Dubois V, Girard-Misguich F, Blaise M, Herrmann JL, Kremer L.

Mol Microbiol. 2017 Jun;104(6):889-904. doi: 10.1111/mmi.13675.

The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium.

Pawelczyk J, Viljoen A, Kremer L, Dziadek J.

Sci Rep. 2017 Feb 16;7:42692. doi: 10.1038/srep42692.

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.

Halloum I, Viljoen A, Khanna V, Craig D, Bouchier C, Brosch R, Coxon G, Kremer L.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02509-16. doi: 10.1128/AAC.02509-16.

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages.

Roux AL, Viljoen A, Bah A, Simeone R, Bernut A, Laencina L, Deramaudt T, Rottman M, Gaillard JL, Majlessi L, Brosch R, Girard-Misguich F, Vergne I, de Chastellier C, Kremer L, Herrmann JL.

Open Biol. 2016 Nov;6(11). Pii: 160185. 27906132.

1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation.

Singh A, Biot C, Viljoen A, Dupont C, Kremer L, Kumar K, Kumar V.

Chem Biol Drug Des. 2017 Jun;89(6):856-861. doi: 10.1111/cbdd.12908.

A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts.

Singh VK, Berry L, Bernut A, Singh S, Carrère-Kremer S, Viljoen A, Alibaud L, Majlessi L, Brosch R, Chaturvedi V, Geurtsen J, Drancourt M, Kremer L.

Cell Microbiol. 2016 Nov;18(11):1489-1507. doi: 10.1111/cmi.12606.

MAB_3551c encodes the primary triacylglycerol synthase involved in lipid accumulation in Mycobacterium abscessus.

Viljoen A, Blaise M, de Chastellier C, Kremer L.

Mol Microbiol. 2016 Nov;102(4):611-627. doi: 10.1111/mmi.13482.

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113.

Design, synthesis, and In vitro antituberculosis activity of 2(5H)-Furanone derivatives.

Ngwane AH, Panayides JL, Chouteau F, Macingwana L, Viljoen A, Baker B, Madikane E, de Kock C, Wiesner L, Chibale K, Parkinson CJ, Mmutlane EM, van Helden P, Wiid I.

IUBMB Life. 2016 Aug;68(8):612-20. doi: 10.1002/iub.1526.

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.

Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L.

Mol Microbiol. 2016 Aug;101(3):515-29. doi: 10.1111/mmi.13406.

Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress.

Gallant JL, Viljoen AJ, van Helden PD, Wiid IJ.

PLoS One. 2016 Jan 29;11(1):e0147706. doi: 10.1371/journal.pone.0147706. eCollection 2016.

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L.

Mol Microbiol. 2016 Mar;99(5):866-83. doi: 10.1111/mmi.13283.

The role of glutamine oxoglutarate aminotransferase and glutamate dehydrogenase in nitrogen metabolism in Mycobacterium bovis BCG.

Viljoen AJ, Kirsten CJ, Baker B, van Helden PD, Wiid IJ.

PLoS One. 2013 Dec 19;8(12):e84452. doi: 10.1371/journal.pone.0084452. eCollection 2013.

Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis.

Sao Emani C, Williams MJ, Wiid IJ, Hiten NF, Viljoen AJ, Pietersen RD, van Helden PD, Baker B.

Antimicrob Agents Chemother. 2013 Jul;57(7):3202-7. doi: 10.1128/AAC.02572-12.

Enregistrer

Enregistrer

Enregistrer

Enregistrer


     
       

   

Enregistrer

Enregistrer

Enregistrer

Enregistrer

Enregistrer

IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

Enregistrer

Enregistrer

Enregistrer

Enregistrer