Fonctions

Chargée de recherche CNRS

Responsable d'équipe

Equipe

Trafic viral, restriction et immunité innée

Contact

email : nathalie.arhel[at]irim.cnrs.fr

Tél : 04 34 35 94 53

 

Publications

ORCID  : 0000-0001-5309-1725

Maarifi G, Fernandez J, Portilho DM, Boulay A, Dutrieux, J, Oddos S, Butler-Browne G, Nisole S, Arhel NJ. RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motif. Commun Biol. 2018, 1:193.

Portilho DM, Fernandez J, Ringeard M, Machado AK, Boulay A, Mayer M, Müller-Trutwin M, Beignon AS, Kirchhoff F, Nisole S, Arhel NJ. Endogenous TRIM5α function is regulated by SUMOylation and nuclear sequestration for efficient innate sensing in dendritic cells. Cell Reports. 2016, 14(2):355-69.

Portilho DM, Persson R, Arhel N. Role of non-motile microtubule-associated proteins in virus trafficking. Biomol Concepts. 2016, 7(5-6):283-292.

Dutrieux J, Maarifi G, Portilho DM, Arhel NJ, Chelbi-Alix MK, Nisole S. PML/TRIM19-dependent inhibition of retroviral reverse-transcription by Daxx. PLoS Pathog. 2015, 11(11):e1005280.

Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJ. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. J Biol Chem. 2015, 290(8):4631-46.

Kotera N, Dubost E, Milanole G, Doris E, Gravel E, Arhel N, Brotin T, Dutasta JP, Cochrane J, Mari E, Boutin C, Léonce E, Berthault P, Rousseau B. A doubly responsive probe for the detection of Cys4-tagged proteins. Chem Commun. 2015, 51(57):11482-4.

Gaudin R, de Alencar BC, Arhel N, Benaroch P. HIV trafficking in host cells: motors wanted! Trends Cell Biol. 2013, 23(12):652-62.

Di Nunzio F, Danckaert A, Fricke T, Perez P, Fernandez J, Perret E, Roux P, Shorte S, Charneau P, Diaz-Griffero F, Arhel NJ. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One. 2012, 7(9):e46037.

Lelek M, Di Nunzio F, Henriques R, Charneau P, Arhel N, Zimmer C. Superresolution imaging of HIV in infected cells with FlAsH-PALM. Proc Natl Acad Sci U S A. 2012, 109(22):8564-9.

Valle-Casuso JC, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, Perez P, Brass AL, Diaz-Griffero F. TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core. J Virol. 2012, 86(10):5931-6.

Di Nunzio F, Félix T, Arhel NJ, Nisole S, Charneau P, Beignon AS.  HIV-derived vectors for therapy and vaccination against HIV. Vaccine. 2012, 30:2499-509.

Iglesias C, Ringeard M, Di Nunzio F, Fernandez J, Gaudin R, Souque P, Charneau P, Arhel N. Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection. Retrovirology. 2011, 8:92.

Arhel N. Revisiting HIV-1 uncoating. Retrovirology. 2010, 7:96.

Arhel N, Kirchhoff F. Host proteins involved in HIV infection: new therapeutic targets. Biochim Biophys Acta. 2010, 1802(3):313-21.

Arhel NJ, Kirchhoff F. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Curr Top Microbiol Immunol. 2009, 339:147-75.

Arhel N, Lehmann M, Clauss K, Nienhaus GU, Piguet V, Kirchhoff F. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J Clin Invest. 2009, 119(10):2965-75.

Strauss G, Lindquist JA, Arhel N, Felder E, Karl S, Haas TL, Fulda S, Walczak H, Kirchhoff F, Debatin KM. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. J Exp Med. 2009, 206(6):1379-93.

Arhel NJ, Charneau P. Bisarsenical labeling of HIV-1 for real-time fluorescence microscopy. Methods Mol Biol. 2009, 485:151-9.

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009, 83(1):73-80.

Arhel NJ, Nisole S, Carthagena L, Coutant F, Souque P, Brussel A, Estaquier J, Charneau P. Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells. Blood. 2008, 112(9):3772-6.

Genin E, Carion O, Mahler B, Dubertret B, Arhel N, Charneau P, Doris E, Mioskowski C. CrAsH-quantum dot nanohybrids for smart targeting of proteins. J Am Chem Soc. 2008, 130(27):8596-7.

Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J. Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci. 2008, 65(17):2621-36.

Arhel N, Charneau P. Observation of the HIV-1 virus in infected cells using microscopy approaches. Pathol Biol (Paris). 2008, 56(1):1-3.

Arhel NJ, Souquere-Besse S, Munier S, Souque P, Guadagnini S, Rutherford S, Prévost MC, Allen TD, Charneau P. HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore. EMBO J. 2007, 26(12):3025-37. Epub 2007 Jun 7.

Arhel N, Munier S, Souque P, Mollier K, Charneau P. Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell type. J Virol. 2006, 80(20):10262-9.

Arhel N, Genovesio A, Kim KA, Miko S, Perret E, Olivo-Marin JC, Shorte S, Charneau P. Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nat Methods. 2006, 3(10):817-24.

Arhel NJ, Souquere-Besse S, Charneau P. Wild-type and central DNA flap defective HIV-1 lentiviral vector genomes: intracellular visualization at ultrastructural resolution levels. Retrovirology. 2006, 3:38.

Clemo NK, Arhel NJ, Barnes JD, Baker J, Moorghen M, Packham GK, Paraskeva C, Williams AC. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem Soc Trans. 2005, 33(Pt 4):676-8.

Barnes JD, Arhel NJ, Lee SS, Sharp A, Al-Okail M, Packham G, Hague A, Paraskeva C, Williams AC. Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells. Apoptosis. 2005, 10(2):301-11.

Arhel NJ, Packham G, Townsend PA, Collard TJ, H-Zadeh AM, Sharp A, Cutress RI, Malik K, Hague A, Paraskeva C, Williams AC. The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. Int J Cancer. 2003, 106(3):364-71.

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IRIM
Institut de Recherche en Infectiologie de Montpellier
UMR 9004 - CNRS / UM
1919 route de Mende - 34293 Montpellier cedex 5
FRANCE

 

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